COVID-19 Infection as a Possible Cause of Ogilvie’s Syndrome

Pirzada, Sarmad; Khan, Zarak; Mahoney, Amanda; Mankani, Ali A

doi:10.7759/cureus.32345

Cited by 3 publications

(5 citation statements)

References 13 publications

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“…While Ogilvie syndrome has been reported in several infectious diseases, including COVID-19, one case only was reported in the context of severe malaria, even if the pathophysiology remains unknown [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Ogilvie Syndrome and Acute Kidney Injury: A Rare Complication of Cesarean Section and Preeclampsia

Stancanelli

Njandjo

Errigo

et al. 2023

JCM

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Ogilvie syndrome, or acute colonic pseudo-obstruction (ACPS) is a rare occurrence, usually following surgery. It consists of a massive dilatation of the cecum, whose diameter becomes greater than 10 cm; its severity is variable, but, if not promptly recognized, it may be life-threatening. Acute kidney injury (AKI) is reported in this context due to both septic complications and to effective hypovolemia. ACPS most commonly affects males and individuals older than 60. In women, the median age at diagnosis is lower due to a strong association with Caesarean sections. The differential diagnosis after delivery may be challenging, due to a potential overlap of symptoms with preeclampsia or hemolysis low platelet elevated liver enzymes (HELLP) syndrome, both associated with AKI. The case herein discussed, regarding a 35-year-old woman, who developed AKI and Ogilvie syndrome after a Caesarean section for preeclampsia, may exemplify these diagnostic and therapeutic challenges, and is intended to raise awareness on this unusual complication of Caesarean delivery.

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Section: Discussionmentioning

confidence: 99%

Ogilvie Syndrome and Acute Kidney Injury: A Rare Complication of Cesarean Section and Preeclampsia

Stancanelli

Njandjo

Errigo

et al. 2023

JCM

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“…Domniemany mechanizm może być związany z enzymem konwertującym angiotensynę 2 (ACE-2), który służy jako receptor umożliwiający wnikanie wirusa SARS-CoV (ang. severe acute respiratory syndrome coronavirus 2) do komórek [30,31]. ACE-2 występuje również w przewodzie pokarmowym i wykazano tam jego zwiększoną ekspresję u chorych na COVID-19, co także prawdopodobnie wiąże się z objawami gastrycznymi takimi jak nudności czy biegunka [30,32].…”

Section: 4unclassified

“…severe acute respiratory syndrome coronavirus 2) do komórek [30,31]. ACE-2 występuje również w przewodzie pokarmowym i wykazano tam jego zwiększoną ekspresję u chorych na COVID-19, co także prawdopodobnie wiąże się z objawami gastrycznymi takimi jak nudności czy biegunka [30,32]. Opisywane są również liczne przypadki, kiedy objawy ze strony przewodu pokarmowego wystąpiły wcześniej niż typowe dla tej choroby objawy ze strony układu oddechowego, a ponadto badania wymazowe z odbytu dają wynik dodatni dłużej niż wymazy z nosogardzieli, co wskazuje na duże znaczenie procesów zachodzących w przewodzie pokarmowym w trakcie infekcji [33].…”

Section: 4unclassified

“…Opisy przypadków pacjentów wskazują, że zespół Ogilviego może się rozwinąć zarówno w trakcie aktywnej, jak i po niedawno przebytej infekcji. Nie wskazuje się jednak na powiązanie występowania ACPO z zastosowaniem wspomaganej wentylacji [30,34]. W opisywanych przypadkach po prawidłowym rozpoznaniu zastosowano klasyczny schemat leczenia neostygminą i zaobserwowano prawidłową odpowiedź na leczenie [30,34,35].…”

Section: 4unclassified

“…Nie wskazuje się jednak na powiązanie występowania ACPO z zastosowaniem wspomaganej wentylacji [30,34]. W opisywanych przypadkach po prawidłowym rozpoznaniu zastosowano klasyczny schemat leczenia neostygminą i zaobserwowano prawidłową odpowiedź na leczenie [30,34,35]. Aby wykluczyć ryzyko wystąpienia zespołu Ogilviego u pacjentów z SARS-CoV-2 ze zwiększonym wzdęciem brzucha i przedłużającymi się zaparciami najlepszym postępowaniem byłoby wykonywanie badań przedmiotowych i wykonywanie zdjęć RTG jamy brzusznej co 12-24 godzin [30].…”

Section: 4unclassified

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Ogilvie Syndrome - summary of knowledge, diagnostics and treatment

Radulski¹,

Tomkiewicz²,

Tomkiewicz³

et al. 2023

J Educ Health Sport

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Introduction and purpose: Ogilvie's syndrome is an acute pseudo-obstruction of the colon characterized by massive dilatation of the large intestine without mechanical obstruction. The aim of this publication is to review publications and case reports concerning this disease and therapeutic management. A brief description of the state of knowledge: Ogilvie's syndrome was first described in 1948. The assumed pathogenesis of the disease is increased activity of the sympathetic nervous system and/or decreased activity of the parasympathetic nervous system. Most often it concerns hospitalized patients, in a serious general condition, after major injuries, operations, and pregnant or postpartum women. The importance of viral infections in the pathogenesis, including COVID-19 in recent years, is also indicated. It is important to eliminate possible organic causes of obstruction and to assess the diameter of the dilated bowel. Therapeutic options include conservative treatment, pharmacological treatment with acetylcholinesterase inhibitors, endoscopic bowel decompression and surgical treatment. Lack of medical intervention can lead to ischemia and intestinal perforation. Conclusion: Ogilvie's syndrome is a rare condition in which complications can be minimized with proper assessment, care and treatment. The progress of pharmacological and endoscopic therapy allows to reduce the need for surgical intervention, and thus - the patient's unnecessary burden.

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Ogilvie’s Syndrome Following Herpes Zoster Infection: A Comprehensive Review of the Literature

Loufopoulos,

Waheed,

Anestiadou

et al. 2024

Cureus

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This systematic review explores the association between herpes zoster (HZ) infection and Ogilvie’s syndrome (acute colonic pseudo-obstruction), evaluating how varicella-zoster virus (VZV) reactivation may contribute to autonomic dysfunction leading to intestinal obstruction. A comprehensive search was conducted in PubMed, Scopus, and Cochrane Library databases up to October 2024, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies included case reports, clinical images, and letters reporting Ogilvie’s syndrome secondary to HZ or VZV infection. After screening 219 publications and additional grey literature, 27 studies describing 28 cases met the inclusion criteria. Data were extracted on patient demographics, clinical manifestations, diagnostic methods, and outcomes. The quality of studies was assessed using the Joanna Briggs Institute critical appraisal checklist. The results from 27 studies encompassing 28 patients with intestinal pseudo-obstruction secondary to VZV or HZ infection indicated a mean age of 60 years, predominantly affecting males (71.5%). Notably, 47.6% had underlying immunosuppressive conditions. The primary clinical manifestations included abdominal distention and severe constipation. Most patients (93%) exhibited a herpetiform rash, primarily in thoracic dermatomes. Symptoms of pseudo-obstruction often preceded the rash (58%), and imaging in the vast majority revealed colonic distension with no intra-abdominal pathology. Treatment focused on conservative management of both pseudo-obstruction and HZ symptoms, with 93% of patients achieving full recovery, while the mortality rate was identified at 7%. The findings suggest that HZ-induced Ogilvie’s syndrome may be an underdiagnosed condition, requiring a high index of suspicion, particularly in immunocompromised patients. Early recognition and conservative treatment can prevent unnecessary surgical interventions. Further studies are needed to clarify the pathophysiological mechanisms linking VZV reactivation to colonic pseudo-obstruction.

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COVID-19 Infection as a Possible Cause of Ogilvie’s Syndrome

Cited by 3 publications

References 13 publications

Ogilvie Syndrome and Acute Kidney Injury: A Rare Complication of Cesarean Section and Preeclampsia

Ogilvie Syndrome and Acute Kidney Injury: A Rare Complication of Cesarean Section and Preeclampsia

Ogilvie Syndrome - summary of knowledge, diagnostics and treatment

Ogilvie’s Syndrome Following Herpes Zoster Infection: A Comprehensive Review of the Literature

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