COVID‐19 infection triggered juvenile systemic lupus erythematosus‐like disease

Belo, Inês Ac de; Gouveia, Catarina; Silva, Tiago Milheiro; Conde, Marta

doi:10.1111/jpc.16116

Cited by 4 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the case reports and case series, the most commonly reported iRMDs were "reactive arthropathies" (n = 47), 14, followed by "inflammatory arthropathies unspecified" (n = 18), 15,23,24,38,[44][45][46][47][48][49][50][51][52] RA (n = 12), [53][54][55][56][57][58][59][60][61][62] and SLE (n = 11). 6,59,[63][64][65][66][67][68][69][70][71] The single observational (cross-sectional) study by Taha et 37 out of 100 people observed (37%) developed "post COVID arthritis." 72 Timeline between onset of COVID-19, iRMD development, and symptom resolution.…”

Section: Resultsmentioning

confidence: 99%

“…Alternatively, 25 separate studies considered that the development of an iRMD after COVID-19 may be the result of an excessive inflammatory response as opposed to an autoimmune process (ie, organ damage may be caused by high levels of inflammatory molecules, rather than autoreactive T and B cells). 6,24,37,47,49,56,58,63,[65][66][67][68][69][70]73,75,76,[78][79][80][81][82][83][84][85][86] Proposed mechanisms included a cytokine storm, 6,24,47,58,63,66,68,[82][83][84] neutrophil extracellular trap formation, 47,65,69,73,75 defects in dendritic cell function, 37,76 and disturbed glutathione metabolism. 80 Colonization of joint spaces and direct damage from SARS−CoV-2 virus.…”

Section: Resultsmentioning

confidence: 99%

“…The exact terminology varied between studies and, for the purposes of this review, reported iRMDs have been grouped according to the ICD‐11 categories: RA, polymyalgia rheumatica and giant cell arteritis, adult‐onset Still disease, juvenile idiopathic arthritis, inflammatory spondylarthritis, SLE, systemic sclerosis, idiopathic inflammatory myopathy, vasculitis, psoriatic arthritis, direct infection of joint, and inflammatory arthropathies unspecified. In the case reports and case series, the most commonly reported iRMDs were “reactive arthropathies” (n = 47), 14,22–43 followed by “inflammatory arthropathies unspecified” (n = 18), 15,23,24,38,44–52 RA (n = 12), 53–62 and SLE (n = 11) 6,59,63–71 . The single observational (cross‐sectional) study by Taha et al reported that following an episode of COVID‐19, 37 out of 100 people observed (37%) developed “post COVID arthritis.” 72 …”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Summarizing Evidence of Associations of COVID‐19 With a Future Diagnosis of Inflammatory Rheumatic and Musculoskeletal Diseases: A Rapid Review

Mudge,

Honey,

Tachoukaft

et al. 2023

Arthritis Care & Research

View full text Add to dashboard Cite

Musculoskeletal symptoms are commonly reported following acute coronavirus disease 2019 (COVID‐19). It is unclear whether those with musculoskeletal symptoms subsequently develop inflammatory rheumatic musculoskeletal disease (iRMD). This review seeks to identify evidence for an association between acute COVID‐19 and subsequent iRMD diagnosis. A rapid review of the literature using a systematic search of Medline, EMBASE and two COVID‐19 databases was undertaken until August 2022. Case studies, case series, cross‐sectional, case‐control, and cohort studies reporting patients with an incident iRMD following COVID‐19 were included. Title and abstract screening were conducted by one reviewer, and full text screening by two reviewers. Data extraction and quality appraisal were by one reviewer, with a second verifying. Study‐type specific critical appraisal tools were used. Results were narratively synthesised. 80 studies were included (69 case reports, 10 case series and 1 cross‐sectional study). Commonly reported iRMDs were ‘reactive arthropathies’ (studies=47), ‘inflammatory arthropathies unspecified’ (studies=18), rheumatoid arthritis (studies=12) and lupus erythematosus (studies=11). The cross‐sectional study reported 37% of those with COVID‐19 developed ‘post‐covid arthritis.’ Time from diagnosis of COVID‐19 to iRMD presentation ranged from 0‐120 days. Several mechanisms were proposed to explain the association between COVID‐19 and iRMD development: auto‐immune processes, aberrant inflammatory responses, colonisation of joint spaces, direct damage from the SARS‐CoV2 virus and genetic predisposition. The level of evidence of the studies included in this review was low, and the quality generally poor. Prospective observational studies are required to confirm associations and likely impact of post COVID‐19 iRMDs at a population level.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Summarizing Evidence of Associations of COVID‐19 With a Future Diagnosis of Inflammatory Rheumatic and Musculoskeletal Diseases: A Rapid Review

Mudge,

Honey,

Tachoukaft

et al. 2023

Arthritis Care & Research

View full text Add to dashboard Cite

show abstract

“…Their hypothesis is based on the presentation of the case of an 11-year-old girl, previously healthy, who after the first wave of the pandemic developed arthralgias, pericarditis, pleurisy and ANA and anti dsDNA positivity, accompanied by a decrease in the level of the C3 fraction of the complement (positive diagnostic criteria for SLE). In the evolution, the clinical symptoms and the biological parameters remitted after corticotherapy and administration of Hydroxychloroquine ( 118 ). A similar case, this time in a 1-and-a-half-year-old girl, was reported by Sobh A. et al.…”

Section: Lupus and Vitamin D3 In The Pandemicmentioning

confidence: 99%

The role of vitamin D in pediatric systemic lupus erythematosus - a double pawn in the immune and microbial balance

Lupu,

Jechel

et al. 2024

Front. Immunol.

View full text Add to dashboard Cite

Having increased popularity during the Covid-19 pandemic, vitamin D3 is currently impressing thanks to the numerous researches aimed at its interactions with the body’s homeostasis. At the same time, there is a peak in terms of recommendations for supplementation with it. Some of the studies focus on the link between autoimmune diseases and nutritional deficiencies, especially vitamin D3. Since the specialized literature aimed at children (patients between 0-18 years old) is far from equal to the informational diversity of the adult-centered branch, this review aims to bring up to date the relationship between the microbial and nutritional balance and the activity of pediatric systemic lupus erythematosus (pSLE). The desired practical purpose resides in a better understanding and an adequate, individualized management of the affected persons to reduce morbidity. The center of the summary is to establish the impact of hypovitaminosis D in the development and evolution of pediatric lupus erythematosus. We will address aspects related to the two entities of the impact played by vitamin D3 in the pathophysiological cascade of lupus, but also the risk of toxicity and its effects when the deficiency is over supplemented (hypervitaminosis D). We will debate the relationship of hypovitaminosis D with the modulation of immune function, the potentiation of inflammatory processes, the increase of oxidative stress, the perfusion of cognitive brain areas, the seasonal incidence of SLE and its severity. Finally, we review current knowledge, post-pandemic, regarding the hypovitaminosis D – pSLE relationship.

show abstract

“…The outcomes and the effectiveness of the vaccine may have varied at a previous COVID-19 incidence. Additionally, COVID-19 can directly cause juvenile SLE if there is a prior or concurrent asymptomatic COVID-19 [ 3 ]. Without the necessary laboratory testing, it is typically impossible to completely rule out the influence of earlier asymptomatic disorders.…”

mentioning

confidence: 99%

Juvenile systemic lupus erythematosus and COVID-19 vaccination

Kleebayoon

2023

North Clin Istanbul

View full text Add to dashboard Cite

COVID‐19 infection triggered juvenile systemic lupus erythematosus‐like disease

Cited by 4 publications

References 7 publications

Summarizing Evidence of Associations of COVID‐19 With a Future Diagnosis of Inflammatory Rheumatic and Musculoskeletal Diseases: A Rapid Review

Summarizing Evidence of Associations of COVID‐19 With a Future Diagnosis of Inflammatory Rheumatic and Musculoskeletal Diseases: A Rapid Review

The role of vitamin D in pediatric systemic lupus erythematosus - a double pawn in the immune and microbial balance

Juvenile systemic lupus erythematosus and COVID-19 vaccination

Contact Info

Product

Resources

About