COVID-19: Is there a silver lining?

Kalra, Kriti; Deshmukh, Paulami

doi:10.5455/jpma.41

Cited by 26 publications

(36 citation statements)

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“…A large fraction of obese patients results in developing T2DM and are considered a group of subjects with an unhealthy condition referred to as 'diabesity' (Kalra, 2013;Ziv and Shafir, 1995). Patients with T2DM account for 90-95% of all diabetes and show a progressive loss of β-cell insulin secretion with abnormal insulin sensitivity due to defective cell signalling after activation of insulin receptors in the target tissues (ADA, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…ER stress being an alteration in the function of organs and cells in the human body in obesity or T2DM, results in a potential target for treating or even preventing these disease-associated alterations in insulin resistance in different insulin target organs. However, it is unclear whether patients with diabesity (i.e., obese patients that develop T2DM) (Kalra, 2013;Ziv and Shafir, 1995) show abnormal tissue and ER homeostasis. In this review, the potential role of ER stress in insulin resistance and the involvement of these alterations in the abnormal organ and cell function seen in diabesity is summarised.…”

Section: Introductionmentioning

confidence: 99%

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Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity

Villalobos-Labra

Subiabre

Toledo

et al. 2019

Molecular Aspects of Medicine

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Diabesity is an abnormal metabolic condition shown by patients with obesity that develop type 2 diabetes mellitus. Patients with diabesity present with insulin resistance, reduced vascular response to insulin, and vascular endothelial dysfunction. Along with the several well-described mechanisms of insulin resistance, a state of endoplasmic reticulum (ER) stress, where the primary human targets are the adipose tissue, liver, skeletal muscle, and the foetoplacental vasculature, is apparent. ER stress characterises by the activation of the unfolded protein response via three canonical ER stress sensors, i.e., the protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1α (IRE1α), and activating transcription factor 6. Slightly different cell signalling mechanisms preferentially enable in diabesity in the ER stress-associated insulin resistance for adipose tissue (IRE1α/X-box binding protein 1 mRNA splicing/c-jun N-terminal kinase 1 activation), skeletal muscle (tribbles-like protein 3 (TRB3)/proinflammatory cytokines activation), and liver (PERK/activating transcription factor 4/TRB3 activation). There is no information in human subjects with diabesity in the foetoplacental vasculature. However, the available literature shows that pregnant women with pre-pregnancy obesity or overweight that develop gestational diabetes mellitus (GDM) and their newborn show insulin resistance. ER stress is recently reported to be triggered in endothelial cells from the human umbilical vein from mothers with pre-pregnancy obesity. However, whether a different metabolic alteration to obesity in pregnancy or GDM is present in women with pre-pregnancy obesity that develop GDM, is unknown. In this review, we summarised the findings on diabesity-associated mechanisms of insulin resistance with emphasis in the primary targets adipose, skeletal muscle, liver, and foetoplacental tissues. We also give evidence on the possibility of a new GDM-associated metabolic condition triggered in pregnancy by maternal obesity, i.e. gestational diabesity, leading to ER stress-associated insulin resistance in the human foetoplacental vasculature.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity

Villalobos-Labra

Subiabre

Toledo

et al. 2019

Molecular Aspects of Medicine

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“…En cuanto al estado nutricional, 72% de los pacientes presentó exceso de peso ya sea por sobrepeso u obesidad, resultado sobrepasado por el encontrado por Firuozi et al, quienes encontraron un 86,5% de diabéticos con exceso de peso (19) . La coexistencia del exceso de peso y la diabetes abre un nuevo concepto en el manejo de esta enfermedad que es la ¨diabesity¨ (diabetes + obesidad), la misma supone una epidemia moderna que enlaza varios mecanismos fisiopatológicos alrededor de la resistencia a la insulina y la hiperglicemia, por lo tanto, en vista a su alta prevalencia y sus efectos negativos, es de suma importancia establecer estrategias de intervención tanto farmacológicas como dietéticas en estos pacientes y llevar un estricto control en ellos de manera a lograr una buena adherencia al tratamiento (20) .…”

Section: Discussionunclassified

Hábitos alimentarios y estado nutricional en pacientes diabéticos con retinopatía que acuden a una Clínica Oftalmológica Privada de la ciudad de Asunción

Meza-Miranda

Nuñez

Serafini

et al. 2019

Mem. Inst. Investig. Cienc. Salud

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“…Patients who are obese and develop T2DM, with or without associated risk factors, are referred to as having 'diabesity' [7,8]. Patients with diabesity show an abnormal functioning of the cardiovascular system worsening its response to vasodilators (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Patients with diabesity show an abnormal functioning of the cardiovascular system worsening its response to vasodilators (e.g. insulin and adenosine) compared with patients with obesity or T2DM only [8,9]. With regard to pre-GDM and obesity, GDM prevalence is also increasing worldwide.…”

Section: Introductionmentioning

confidence: 99%

Placental metabolism and disease

Sobrevía

2018

Placenta

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COVID-19: Is there a silver lining?

Cited by 26 publications

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Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity

Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity

Hábitos alimentarios y estado nutricional en pacientes diabéticos con retinopatía que acuden a una Clínica Oftalmológica Privada de la ciudad de Asunción

Placental metabolism and disease

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