2020
DOI: 10.24272/j.issn.2095-8137.2020.053
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COVID-19-like symptoms observed in Chinese tree shrews infected with SARS-CoV-2

Abstract: The coronavirus disease 2019 (COVID-19) pandemic continues to pose a global threat to the human population. Identifying animal species susceptible to infection with the SARS-CoV-2/ HCoV-19 pathogen is essential for controlling the outbreak and for testing valid prophylactics or therapeutics based on animal model studies. Here, different aged Chinese tree shrews (adult group, 1 year old; old group, 5–6 years old), which are close relatives to primates, were infected with SARS-CoV-2. X-ray, viral shedding, labor… Show more

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Cited by 59 publications
(72 citation statements)
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“…Phylogenetic sequencing of their ACE-2 receptors reveals a high sequence similarity between tree shrews and humans (up to 81%) [ 105 ]. These observations have been supported by laboratory inoculations that have reported tree shrews can not only be infected by SARS-CoV-2 but also can develop minor signs of respiratory infections [ 225 , 226 ]. Despite displaying subtle pathology, it is speculated that tree shrews might serve as an intermediate host or as an asymptomatic carrier of SARS-CoV-2 [ 227 ].…”
Section: Animal Host Diversity Of Sars-cov-2mentioning
confidence: 73%
“…Phylogenetic sequencing of their ACE-2 receptors reveals a high sequence similarity between tree shrews and humans (up to 81%) [ 105 ]. These observations have been supported by laboratory inoculations that have reported tree shrews can not only be infected by SARS-CoV-2 but also can develop minor signs of respiratory infections [ 225 , 226 ]. Despite displaying subtle pathology, it is speculated that tree shrews might serve as an intermediate host or as an asymptomatic carrier of SARS-CoV-2 [ 227 ].…”
Section: Animal Host Diversity Of Sars-cov-2mentioning
confidence: 73%
“…Amplification was performed using an ABI Prism ViiA 7 Sequence Detector system (Applied Biosystems, Thermo Fisher, USA). A positive control consisting of SARS-CoV-2 RNA reference material (National Institute of Metrology, China; GBW(E)091089) and a negative control consisting of blank elution buffer were included in each reaction ( Xu et al, 2020 ).…”
Section: Methodsmentioning
confidence: 99%
“…Rodents exist in sufficient numbers and densities for continuous transmission and are often in close proximity to humans, but so far experimental studies indicate a low probability or no risk of SARS‐CoV‐2 infection for mice and rats 13 . Interestingly, it has been found more recently that Chinese tree shrews, a squirrel‐like mammal with a wide distribution in Southeast Asia, could not only be infected with SARS‐CoV‐2 but also developed clinical signs analogous to COVID‐19 in humans 15 . Chinese tree shrews have been used as animal models in viral hepatitis, psychosocial and visual defect studies due to their phylogenetical closeness to primates 16 …”
Section: Origin Of Sars‐cov‐2: What Have We Learned So Far?mentioning
confidence: 99%