COVID-19 lung disease is a pulmonary vasculopathy

Lloyd-Jones, G.; Alcock, R.; Oudkerk, M.

doi:10.1016/j.crad.2024.04.002

Clinical Radiology

2024

DOI: 10.1016/j.crad.2024.04.002

|View full text |Cite

COVID-19 lung disease is a pulmonary vasculopathy

G. Lloyd-Jones,

R. Alcock,

M. Oudkerk

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook

Kruger,

Joffe,

Lloyd-Jones

et al. 2024

Semin Thromb Hemost

View full text Add to dashboard Cite

Long coronavirus disease 2019 (COVID-19)—a postacute consequence of severe acute respiratory syndrome coronavirus 2 infection—manifests with a broad spectrum of relapsing and remitting or persistent symptoms as well as varied levels of organ damage, which may be asymptomatic or present as acute events such as heart attacks or strokes and recurrent infections, hinting at complex underlying pathogenic mechanisms. Central to these symptoms is vascular dysfunction rooted in thrombotic endothelialitis. We review the scientific evidence that widespread endothelial dysfunction (ED) leads to chronic symptomatology. We briefly examine the molecular pathways contributing to endothelial pathology and provide a detailed analysis of how these cellular processes underpin the clinical picture. Noninvasive diagnostic techniques, such as flow-mediated dilation and peripheral arterial tonometry, are evaluated for their utility in identifying ED. We then explore mechanistic, cellular-targeted therapeutic interventions for their potential in treating ED. Overall, we emphasize the critical role of cellular health in managing Long COVID and highlight the need for early intervention to prevent long-term vascular and cellular dysfunction.

show abstract

Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook

Kruger,

Joffe,

Lloyd-Jones

et al. 2024

Semin Thromb Hemost

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

COVID-19 lung disease is a pulmonary vasculopathy

Cited by 1 publication

References 46 publications

Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook

Vascular Pathogenesis in Acute and Long COVID: Current Insights and Therapeutic Outlook

Contact Info

Product

Resources

About