COVID-19 Mortality and Vaccine Coverage — Hong Kong Special Administrative Region, China, January 6, 2022–March 21, 2022

Smith, Dallas; Hakim, Avi J; Leung, Gabriel M.; Xu, Wenbo; Schluter, W William; Novak, Ryan T; Marston, Barbara; Hersh, Bradley S.

doi:10.15585/mmwr.mm7115e1

Cited by 109 publications

(105 citation statements)

References 3 publications

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“…According to the newly announced Chinese government data, the case/death rates of those vaccinated with BNT162b2 and those vaccinated with CoronoVac were as follows: 0.21% vs. 1.28% after the 1st dose of vaccine, 0.04% vs. 0.31% after the 2nd dose of vaccine, and 0.02% vs. 0.04% after three doses of vaccine, respectively. It was emphasized that the protection of the BNT162b2 vaccine was better, especially in two-dose vaccinations [ 22 ].…”

Section: Discussionmentioning

confidence: 99%

Factors affecting the serologic response to SARS-CoV-2 vaccination in patients with solid tumors: A prospective study

Erdoğan

Ekinci

Akçalı

2022

Journal of Infection and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Factors affecting the serologic response to SARS-CoV-2 vaccination in patients with solid tumors: A prospective study

Erdoğan

Ekinci

Akçalı

2022

Journal of Infection and Chemotherapy

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“…Omicron was reported in November 2021 in a quarantined hotel in Hong Kong, China ( 11 ). Patients with COVID-19 infected with the Omicron variant have continuously been reported in China ( 12 – 14 ). Currently, as of April 24, in Shanghai, China, the Omicron variant has caused a large number of SARS-CoV-2 infections, and COVID-19 has caused 87 deaths.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Pulmonary CT Characteristics of Patients Infected With the SARS-CoV-2 Omicron Variant Compared With Those of Patients Infected With the Alpha Viral Strain

Yang

Wang

Huang

et al. 2022

Front. Public Health

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BackgroundOmicron has become the dominant variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) globally. We aimed to compare the clinical and pulmonary computed tomography (CT) characteristics of the patients infected with SARS-CoV-2 Omicron with those of patients infected with the Alpha viral strain.MethodsClinical profiles and pulmonary CT images of 420 patients diagnosed with coronavirus disease-2019 (COVID-19) at Ningbo First Hospital between January 2020 and April 2022 were collected. Demographic characteristics, symptoms, and imaging manifestations of patients infected with the SARS-CoV-2 Omicron variant were compared with those of patients infected with the Alpha strain.ResultsA total of 38 patients were diagnosed to be infected with the Alpha strain of SARS-CoV-2, whereas 382 patients were thought to be infected with the Omicron variant. Compared with patients infected with the Alpha strain, those infected with the Omicron variant were younger, and a higher proportion of men were infected (P < 0.001). Notably, 93 (24.3%) of the patients infected with Omicron were asymptomatic, whereas only two (5.3%) of the patients infected with the Alpha strain were asymptomatic. Fever (65.8%), cough (63.2%), shortness of breath (21.1%), and diarrhea (21.1%) were more common in patients infected with the SARS-CoV-2 Alpha strain, while runny nose (24.1%), sore throat (31.9%), body aches (13.6%), and headache (12.3%) were more common in patients with the Omicron variant. Compared with 33 (86.84%) of 38 patients infected with the Alpha strain, who had viral pneumonia on pulmonary CT images, only 5 (1.3%) of 382 patients infected with the Omicron variant had mild foci. In addition, the distribution of opacities in the five patients was unilateral and centrilobular, whereas most patients infected with the Alpha strain had bilateral involvement and multiple lesions in the peripheral zones of the lung.ConclusionThe SARS-CoV-2 Alpha strain mainly affects the lungs, while Omicron is confined to the upper respiratory tract in patients with COVID-19.

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“…Vaccination is associated with a much lower risk of death 33 . Unfortunately, the vaccination rate was particularly low among older adults aged 80 years or above.…”

Section: Discussionmentioning

confidence: 99%

“…For sera tested positive by sVNT, we assessed the NAb against the ancestral virus and Omicron sublineages BA.1 and BA.2 using a cVNT. We interpreted our serosurveillance findings with the epidemiological and genomic information of the fifth wave of COVID-19 in Hong Kong, which exceeded 1 million cases by March 18, 2022 32 , 33 .…”

Section: Introductionmentioning

confidence: 99%

Contribution of low population immunity to the severe Omicron BA.2 outbreak in Hong Kong

et al. 2022

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Monitoring population protective immunity against SARS-CoV-2 variants is critical for risk assessment. We hypothesize that Hong Kong’s explosive Omicron BA.2 outbreak in early 2022 could be explained by low herd immunity. Our seroprevalence study using sera collected from January to December 2021 shows a very low prevalence of neutralizing antibodies (NAb) against ancestral virus among older adults. The age group-specific prevalence of NAb generally correlates with the vaccination uptake rate, but older adults have a much lower NAb seropositive rate than vaccination uptake rate. For all age groups, the seroprevalence of NAb against Omicron variant is much lower than that against the ancestral virus. Our study suggests that this BA.2 outbreak and the exceptionally high case-fatality rate in the ≥80 year-old age group (9.2%) could be attributed to the lack of protective immunity in the population, especially among the vulnerable older adults, and that ongoing sero-surveillance is essential.

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COVID-19 Mortality and Vaccine Coverage — Hong Kong Special Administrative Region, China, January 6, 2022–March 21, 2022

Cited by 109 publications

References 3 publications

Factors affecting the serologic response to SARS-CoV-2 vaccination in patients with solid tumors: A prospective study

Factors affecting the serologic response to SARS-CoV-2 vaccination in patients with solid tumors: A prospective study

Clinical and Pulmonary CT Characteristics of Patients Infected With the SARS-CoV-2 Omicron Variant Compared With Those of Patients Infected With the Alpha Viral Strain

Contribution of low population immunity to the severe Omicron BA.2 outbreak in Hong Kong

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