COVID-19 mRNA Vaccination, ABO Blood Type and the Severity of Self-Reported Reactogenicity in a Large Healthcare System: A Brief Report of a Cross-Sectional Study

Abstract

It has been anecdotally observed that ABO blood type may have an impact on the severity of the side-effects experienced by those receiving mRNA vaccination for COVID-19. MethodsAs part of a larger study, a retrospective cross-sectional survey was made available to approximately 33,000 front-line healthcare workers, students and volunteers who were offered voluntary vaccination in a statewide healthcare system during phase one of the state's vaccine roll-out. A secondary endpoint of the survey was to determine if there was any relationship between vaccination reactogenicity and ABO blood type. Results4009 responses were received -a 12.15% response rate. 3700 respondents answered the blood type question, and of those, 2878 knew their blood type. By Kruskal-Wallis test, there was no statistically significant association between any blood type and any side effect for either of the COVID-19 mRNA vaccines. ConclusionsCOVID-19 mRNA vaccination may cause significant reactogenicity. However, ABO blood type does not appear to be a predictor of vaccine reactogenicity.

The impact of ABO blood types on humoral immunity responses and antibody persistency after different COVID‐19 vaccine regimens

“…In a study by Ohoud et al, no correlation was found between the adverse events severity of the vaccine and ABO blood types 8 . In line with their findings, ABO blood groups were not predictors of COVID‐19 vaccine reactogenicity in the Allan et al study 25 . However, the investigated AEs in our study were the long‐term ones and the associated data on this issue is still rare.…”

“…study. 25 However, the investigated AEs in our study were the long-term ones and the associated data on this issue is still rare.…”

Reactions following Pfizer-BioNTech COVID-19 mRNA vaccination and related healthcare encounters among 7,077 children aged 5-11 years within an integrated healthcare system

“…The most frequently reported post-vaccine local reaction was pain around the injection site (48% and 30% for dose 1 and 2, respectively), and the most common reported systemic reactions were fatigue (20% and 19%), followed by headache (12% and 13%), myalgia (9% and 10%) and fever (5% and 9%). These vaccine-associated reactions have been consistently observed in this order across many populations and age groups [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] . In the current study, care givers of children of younger ages were more likely to report seeking care for their child’s post-vaccine symptoms.…”

Association between ABO blood groups and the risk of infection with SARS-CoV-2 in Iraq

“…However, people with various ABO blood groups exhibit varying degrees of reactogenicity to immunization by RNA vaccines developed by Pfizer and Sinopharm. 14 Individuals with blood group A experienced more severe adverse effects than those with blood group O, and the extent of reactogenicity appeared to be linked to the blood group, as presented in Table 1 and Figure 1 .…”