COVID-19 Neurologic Complication with CNS Vasculitis-Like Pattern

Hanafi, Riyad; Roger, Pierre-Alexandre; Perin, Benjamin; Kuchcinski, Grégory; Deleval, Nicolas; Dallery, F.; Michel, Detlef; Hacein‐Bey, Lotfi; Pruvo, Jean‐Pierre; Outteryck, Olivier; Constans, Jean Marc

doi:10.3174/ajnr.a6651

Cited by 137 publications

(152 citation statements)

References 19 publications

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“…ACE2 receptor has higher expression in neurons and cerebral vessel endothelial cells which can cause high level of CNS invasion. [185,186] Histologic evidence of COVID-19-induced vasculitis has been reported in several other organs including lung, kidney, liver and skin. [186] Similarly, virus-related endothelial injury and endotheliitis might cause CNS vasculitis.…”

Section: Cns Vasculitismentioning

confidence: 99%

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Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

186

182

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Coronavirus disease-19 (COVID-19) pandemic continues to grow all over the world. Several studies have been performed, focusing on understanding the acute respiratory syndrome and treatment strategies. However, there is growing evidence indicating neurological manifestations occur in patients with COVID-19. Similarly, the other coronaviruses (CoV) epidemics; severe acute respiratory syndrome (SARS-CoV-1) and Middle East respiratory syndrome (MERS-CoV) have been associated with neurological complications. Methods: This systematic review serves to summarize available information regarding the potential effects of different types of CoV on the nervous system and describes the range of clinical neurological complications that have been reported thus far in COVID-19. Results: Two hundred and twenty-five studies on CoV infections associated neurological manifestations in human were reviewed. Of those, 208 articles were pertinent to COVID-19. The most common neurological complaints in COVID-19 were anosmia, ageusia, and headache, but more serious complications, such as stroke, impairment of consciousness, seizures, and encephalopathy, have also been reported. Conclusion: There are several similarities between neurological complications after SARS-CoV-1, MERS-CoV and COVID-19, however, the scope of the epidemics and number of patients are very different. Reports on the neurological complications after and during COVID-19 are growing on a daily basis. Accordingly, comprehensive knowledge of these complications will help health care providers to be attentive to these complications and diagnose and treat them timely.

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Section: Cns Vasculitismentioning

confidence: 99%

“…Hanafi R, et al [185] reported a 65-year-old man with COVID-19 who had extensive diffuse subcortical ischemic lesions in the brain resembling cerebral vasculitis. (Figure 8) He also developed a characteristic lower extremity skin rash.…”

Section: Cns Vasculitismentioning

confidence: 99%

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Dorche

Huot

Osherov

et al. 2020

Journal of the Neurological Sciences

186

182

View full text Add to dashboard Cite

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“…However, the 18-year-old boy died at home, 11 days after discharge. Autopsy of the brain showed cerebral vasculitis probably associated with COVID-19 [24,25].…”

Section: Characteristics Of Patients Admitted With Covid-19mentioning

confidence: 99%

Infection Control and Management of COVID-19: Challenges for Paediatric Tertiary Care Hospitals

Remppis¹,

Ganzenmueller²,

Vasconcelos³

et al. 2020

Preprint

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PURPOSE: To describe infection control measures and patient management at a tertiary children’s hospital in southern Germany during the COVID-19 pandemic.METHODS: Prospective, observational study of infection control measures, patient management, clinical and virologic data of paediatric patients treated at our hospital during the COVID-19 pandemic from February to May 2020. Infection control measures were documented beginning with preparation for the pandemic. All paediatric patients with suspected SARS-CoV-2 infection were prospectively included in the study.RESULTS: With local triage, restraint of patient admission and testing strategies implemented, healthcare capacity remained adequate and no healthcare-associated infections occurred. Workload in the paediatric emergency department significantly decreased following the lockdown of schools and kindergartens. 7 of 174 (4%) children with and 2 of 208 (1%) children without typical symptoms, respectively, were diagnosed with COVID-19 by PCR. Six out of nine inpatients treated for COVID-19 had underlying comorbidities, two were admitted to the intensive care unit. One patient died shortly after discharge.CONCLUSIONS: While COVID-19 generally causes mild disease in children, severe illness and fatal cases may occur, particularly among children with underlying diseases. Tertiary children’s hospitals may face challenges with treating potential high-risk patients during the pandemic. Thus, timely establishment of effective testing and triage strategies is crucial.

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“…The pathophysiology is not yet fully understood and may be multifactorial including microthrombosis with secondary haemorrhage, dysregulated coagulation, e.g. disseminated intravascular coagulation and immune thrombocytopenic purpura [5], and vascular hyperpermeability in the context of COVID-19 cytokine storm [1], endotheliitis [6] and vasculitis [7].…”

Section: Introductionmentioning

confidence: 99%

Non-aneurysmal subarachnoid haemorrhage in COVID-19

et al. 2020

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Coronavirus disease of 2019 (COVID-19) is associated with hypercoagulopathy, but haemorrhage, including spontaneous intracerebral parenchymal haemorrhage and diffuse petechial cerebral haemorrhage, has also been reported. We present two cases of nonaneurysmal subarachnoid haemorrhage (SAH) in patients with severe COVID-19. Careful review of neuroimaging for haemorrhagic complications of COVID-19 should be undertaken, particularly for those patients receiving enhanced prophylaxis for venous thromboembolism. Although likely to be a marker of severe disease, non-aneurysmal SAH can be associated with favourable outcome.

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COVID-19 Neurologic Complication with CNS Vasculitis-Like Pattern

Cited by 137 publications

References 19 publications

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic

Infection Control and Management of COVID-19: Challenges for Paediatric Tertiary Care Hospitals

Non-aneurysmal subarachnoid haemorrhage in COVID-19

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