COVID-19 not detected in peritoneal fluid: a case of laparoscopic appendicectomy for acute appendicitis in a COVID-19-infected patient

Ngaserin, Sabrina; Koh, Frederick H.; Ong, Biauw Chi; Chew, Min Hoe

doi:10.1007/s00423-020-01891-2

Cited by 86 publications

(85 citation statements)

References 7 publications

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“…Rather, our case highlights the concurrence of a common surgical emergency and COVID-19. In light of our data and of the recent failure to detect COVID-19 in the peritoneal uid of a COVID-19 patient with acute appendicitis [11], we would consider the risk of infectious aerosol development during laparoscopic appendectomy in COVID-19 patients with mild symptoms to be relatively low. However, this is only one case report which clearly limits generalization and precautions such as appropriate personal protective equipment should be used whenever COVID-19 is suspected in a patient, especially as infection of operating personal might result from other sources such as the respiratory system.…”

Section: Resultsmentioning

confidence: 91%

“…There is limited information regarding COVID-19 and acute appendicitis. While one report demonstrating SARS-CoV-2 in the peritoneal uid of a patient with COVID-19 has been published [10], Ngaserin et al reported recently that they could not detect SARS-CoV-2 in the peritoneal uid of a COVID-19 patient with acute appendicitis [11]. Another case report recently described an appendectomy in a patient with COVID-19 but no investigations regarding the presence of SARS-CoV-2 in the appendix were performed [12].…”

Section: Resultsmentioning

confidence: 99%

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No SARS-CoV-2 detected in the vermiform appendix of a COVID-19 patient with appendicitis: a case report

Wolf¹,

Pietsch²,

Radosa³

et al. 2020

Preprint

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Background:SARS-CoV-2, the virus causing corona virus disease 2019 (COVID-19), has been demonstrated to infect the gastrointestinal tract and might therefore be a source of infection for the surgical team during abdominal operations. One of the most common surgical procedures performed is appendectomy. However, reports of virologic testing of appendiceal tissue specimens in COVID-19 patients are lacking. We sought to determine whether SARS-CoV-2 is present in the appendectomy specimen of a patient with COVID-19. Case presentation:A female patient presented to the emergency department of our tertiary care academic hospital with lower abdominal pain, fever, nausea, and vomiting. She was admitted to the gynecological floor because of suspected pelvic inflammatory disease. Due to worsening symptoms, a laparoscopy was performed the next day and a severely inflamed appendix was detected. Laparoscopic appendectomy was performed without complications. A few hours postoperatively, the patient was tested positive for corona virus disease 2019 (COVID 19). Real-time reverse transcription polymerase chain reaction analysis targeting the SARS-CoV-2 E-gene was performed on the appendectomy specimen. SARS-CoV-2 could not be detected. During her hospital stay, the patient developed mild respiratory symptoms while the postoperative course was otherwise uncomplicated. Conclusions:The absence of SARS-CoV-2 in the appendectomy specimen of our case adds to the preliminary available evidence indicating that appendectomy in COVID-19 patients with mild disease carries probably a low risk of infection by aerosols generated during the procedure.

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Section: Resultsmentioning

confidence: 91%

Section: Resultsmentioning

confidence: 99%

No SARS-CoV-2 detected in the vermiform appendix of a COVID-19 patient with appendicitis: a case report

Wolf¹,

Pietsch²,

Radosa³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…SARS‐CoV2‐RNA has been isolated in blood and feces, while there are conflicting experiences regarding its presence in peritoneal fluid 5,6 . To the best of our knowledge, this is the first report of bile analysis for the presence of SARS‐CoV‐2.…”

mentioning

confidence: 94%

The COVID-19 conundrum: SARS-CoV-2 is not present in bile

Kabir

Koh

Huang

et al. 2020

British Journal of Surgery

Self Cite

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“…Some reports have identi ed the presence of genetic material in the PF, and it was associated with PD failure (12,13). However, other reports have not detected the presence of the virus in the PF (14)(15)(16)(17).…”

Section: Read Full Licensementioning

confidence: 99%

Detection of SARS-CoV-2 in peritoneal fluid from patients with kidney disease and COVID-19: report of two cases

Ibarra-Hernandez

Alcantar-Vallín

Cabrera-Silva

et al. 2020

Preprint

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Background: Coronavirus disease-2019 (COVID-19) has a broad clinical presentation, involving multiple organs besides the respiratory system. Currently, there is little evidence available on the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in peritoneal fluid (PF). In this study, we describe the detection of SARS-CoV-2 in the PF of two patients with COVID 19 and kidney disease.Case presentation: Case 1: A 71-year-old woman with a history of end-stage kidney disease who presented with a 15-day evolution of progressive dyspnea, accompanied by dry cough and fever; IgM antibodies to SARS-CoV-2 were detected on admission. Real-time SARS-CoV-2 polymerase chain reaction (qRT-PCR) in the PF was positive. Three days after admission the patient's respiratory distress improved and she was discharged after 8 days of hospitalization.Case 2: A 78-year-old woman, with type 2 diabetes, hypertension, a 15-day history of polypnea, and a 5-day onset of fever and dyspnea. IgM and IgG antibodies to SARS-CoV-2 were detected on admission, as well as a positive nasopharyngeal qRT-PCR test for SARS-CoV-2. During hospitalization she developed acute kidney injury, requiring peritoneal dialysis, SARS-CoV-2 was confirmed in PF by qRT-PCRConclusions: These two cases highlights the importance of increasing the level of awareness for the presence and possible SARS-CoV-2 transmission through non-respiratory routes, like peritoneal fluid.Emphasis should be given to appropriate preventive strategies for minimizing the risk of transmission of COVID-19 from patients on peritoneal dialysis in both inpatient and outpatient settings.

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COVID-19 not detected in peritoneal fluid: a case of laparoscopic appendicectomy for acute appendicitis in a COVID-19-infected patient

Cited by 86 publications

References 7 publications

No SARS-CoV-2 detected in the vermiform appendix of a COVID-19 patient with appendicitis: a case report

No SARS-CoV-2 detected in the vermiform appendix of a COVID-19 patient with appendicitis: a case report

The COVID-19 conundrum: SARS-CoV-2 is not present in bile

Detection of SARS-CoV-2 in peritoneal fluid from patients with kidney disease and COVID-19: report of two cases

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