COVID-19 Omicron variant-inhibitory in silico evidence for phytocompounds of an ancient Ayurvedic formulation

Abstract

The emerging SARS-COV-2 variants and the global COVID-19 outbreak underscore the urgent need for prophylactics and improved antivirals. Scientists are racing to develop vaccines and antiviral drugs. While vaccinations will be the primary pandemic prophylactic and, appropriate antiviral medications will be needed as a treatment strategy. The variant strains of the virus spawned the second and third waves in several countries, and it affected universally. Antiviral drugs with novel mechanisms of action are still needed to combat emerging SARS-CoV-2 mutations. The present research confirmed in silico the prospective efficacy of an ancient Ayurvedic formulation made for prophylactic and treatment material against symptoms similar to the COVID-19 Wuhan_Hu_1st strain, which had been provided with similar in silico evidence in our earlier report. Clinical studies with safe chemical cocktails may have prospects for countries where the practice of Ayurveda is not legal.