COVID-19 Outcomes in Patients With Uncontrolled HIV-1 Infection

Calza, Leonardo; Bon, Isabella; Borderi, Marco; Colangeli, Vincenzo; Borioni, Aurora; Re, Maria Carla; Viale, Pierluigi

doi:10.1097/qai.0000000000002537

Cited by 18 publications

(19 citation statements)

References 17 publications

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“…In the study conducted by Calza et al all the nine HIV‐positive patients with CD4 count less than 258 fully recovered, which supports the hypothesis of our study. 26 Additionally, in Kumar et al's and Patel RH. 's study, the patients had a CD4 count less than 500 and again completely recovered.…”

Section: Discussionmentioning

confidence: 99%

The clinical outcomes of COVID‐19 in HIV‐positive patients: A systematic review of current evidence

SeyedAlinaghi

MohsseniPour

Barzegary

et al. 2021

Immunity Inflam & Disease

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Introduction Patients with chronic underlying diseases are more susceptible to coronavirus disease 2019 (COVID‐19) complications. Recent studies showed people living with HIV (PLWH) are not at greater risk than the general population. Few studies have reviewed the impacts of COVID‐19 on PLWH. The purpose of this systematic review was to investigate the impact of COVID‐19 on patients infected with HIV. Methods We executed a systematic search using four databases of PubMed, Scopus, Science Direct, and Web of Science and screened the records in two steps based on their title/abstract and full text. This study follows the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) checklist to elevate the validity and reliability of its results. Results We reviewed 36 studies. The patients' age was above 20 years in all studies. In almost all studies, the inflammatory parameters were reported high. In most of the studies, all HIV patients completely recovered from the COVID 19 infection. Although CD4 count was not recorded in all studies, the minimum level was reported as 12 cells/µl. Conclusion Based on the current review, we concluded that HIV patients at advanced stages (3 or 4) of the disease, whose CD4 counts are low, may show less severe COVID‐19 infection symptoms. Similarly, Interference can reduce the severity of immune reactions and subsequent cytokine storms and consequently mitigate the symptoms. Therefore, in most of the studies, the majority of HIV patients showed no severe symptoms and completely recovered from COVID 19 infection.

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Section: Discussionmentioning

confidence: 99%

The clinical outcomes of COVID‐19 in HIV‐positive patients: A systematic review of current evidence

SeyedAlinaghi

MohsseniPour

Barzegary

et al. 2021

Immunity Inflam & Disease

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show abstract

“…In fact, a few large-scale retrospective analyses indicated that people living with HIV are at higher risk of developing and dying from severe COVID-19 [151][152][153]. Whether this holds true, it is important to carry out studies by comparing controlled versus uncontrolled HIV infection and by analyzing the role of other comorbidities, which are likely to bias the outcome of any meaningful interactions between the two pathogens in co-infected individuals [154,155].…”

Section: Viral Persistence In Immunocompromised Hostsmentioning

confidence: 99%

Insights into SARS-CoV-2 Persistence and Its Relevance

Desimmie

Raru

Awadh

et al. 2021

Viruses

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), continues to wreak havoc, threatening the public health services and imposing economic collapse worldwide. Tailoring public health responses to the SARS-CoV-2 pandemic depends on understanding the mechanism of viral replication, disease pathogenesis, accurately identifying acute infections, and mapping the spreading risk of hotspots across the globe. However, effective identification and isolation of persons with asymptomatic and mild SARS-CoV-2 infections remain the major obstacles to efforts in controlling the SARS-CoV-2 spread and hence the pandemic. Understanding the mechanism of persistent viral shedding, reinfection, and the post-acute sequalae of SARS-CoV-2 infection (PASC) is crucial in our efforts to combat the pandemic and provide better care and rehabilitation to survivors. Here, we present a living literature review (January 2020 through 15 March 2021) on SARS-CoV-2 viral persistence, reinfection, and PASC. We also highlight potential areas of research to uncover putative links between viral persistence, intra-host evolution, host immune status, and protective immunity to guide and direct future basic science and clinical research priorities.

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“…Data on patients with uncontrolled HIV-1 infection, i.e., with detectable HIV-1 RNA and poor immunological status, are scarce but small studies indicated no pronounced impact of an ongoing HIV-1 infection on COVID-19 clinical outcome [525]. Although HIV-1 altered the response of CD4 + T , CD8 + T, and natural killer cell subsets, COVID-19 disease in people living with HIV (PWH) remained comparable to HIV-negative participants [526].…”

Section: Interferon Responsementioning

confidence: 99%

SARS-CoV-2 Portrayed Against HIV: Contrary Viral Strategies in Similar Disguise

Duerr¹,

Jimenez²,

Dittmann³

2021

Preprint

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SARS-CoV-2 and HIV are zoonotic viruses that rapidly reached pandemic scale causing global losses and fear. The COVID-19 and AIDS pandemics ignited massive efforts worldwide to develop antiviral strategies and characterize viral architectures, biological and immunological properties, and clinical outcomes. Although both viruses have a comparable appearance as enveloped, positive-stranded RNA viruses with envelope spikes mediating cellular entry, the entry process, downstream biological and immunological pathways, clinical outcomes, and disease courses are strikingly different. This review provides a systemic comparison of both viruses’ structural and functional characteristics delineating their distinct strategies for efficient spread.

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COVID-19 Outcomes in Patients With Uncontrolled HIV-1 Infection

Cited by 18 publications

References 17 publications

The clinical outcomes of COVID‐19 in HIV‐positive patients: A systematic review of current evidence

The clinical outcomes of COVID‐19 in HIV‐positive patients: A systematic review of current evidence

Insights into SARS-CoV-2 Persistence and Its Relevance

SARS-CoV-2 Portrayed Against HIV: Contrary Viral Strategies in Similar Disguise

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