Agricultural production systems currently face multiple challenges: Climate change, natural resource depletion, and supply chain disruption, together with global population growth. As sustainable agriculture must simultaneously deliver myriad services (e.g. provide food security, maintain natural resources, retain and improve framers' profitability, and sustain biodiversity), a systemic and multidisciplinary approach is thus needed. In this context, new technologies based on sensors, automatic machines, robots, and digital applications show much potential. The special section of the Agronomy Journal, entitled, "Agricultural and Biological Sciences: Plant, Soil, Animal and Environment Nutrient Management," brings together a coherent set of research studies. All papers published in this special section address current, relevant topics for agriculture, biology and environmental sciences with a multidisciplinary approach aimed at generating new scientific information on digital technologies, bioinformatics, plant science, soil resources, agricultural waste, and environmentally conscious approaches. A total of 58 papers were submitted, each of which was evaluated by expert reviewers using a double-blind reviewing process and 25 full text papers were accepted for publication in the special section. The present paper highlights the findings of the published papers, with the aim of bringing cuttingedge innovation to applied research in agriculture and biology. The published papers here provide new knowledge and viable solutions for better performance in agricultural and biological sciences. New technologies will change the concept of farming and agribusiness making it more profitable, efficient, safer, attractive, simple, smart, and finally sustainable. Rural development and food security policies must support and finance the easiest possible access to new technologies for agricultural producers.