“…COVID-19, an acute respiratory infection caused by the SARS-CoV-2 virus ( Jiang et al, 2020 , Richardson et al, 2020 ; A. S. Tulbah & Lee, 2021 ), is currently one of the major cause of death worldwide ( Ciotti et al, 2020 ; A. Tulbah, 2021 ). COVID-19 treatment has recently focused on M pro - the enzyme as a target because it is responsible for the Coronavirus replication ( Panikar et al, 2021 ; Arun Dev Sharma, 2020 ; Arun D Sharma and Inderjeet, 2020 , Valussi et al, 2021 ).…”