COVID-19 Pandemic: Ways Forward

Wong, Raymond Siu Ming; Lai, Kenny H W; Huang, Suber; Jonas, Jost B.; Lam, Dennis Shun Chiu

doi:10.1097/apo.0000000000000283

Cited by 7 publications

(7 citation statements)

References 5 publications

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“…The coronavirus disease 2019 (COVID-19) was first reported in early December 2019 in Wuhan city, China and, subsequently, the disease spread through the country in approximately 3 months. In addition to the strategy of early identification, contact tracing, isolation, and treatment, China locked down several major cities [ 1 ]. However, major outbreaks were reported in many other countries, including the United States, Italy, Spain, Iran, South Korea, and Japan, so the World Health Organization (WHO) declared COVID-19 a pandemic on 11 March 2020 [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…However, major outbreaks were reported in many other countries, including the United States, Italy, Spain, Iran, South Korea, and Japan, so the World Health Organization (WHO) declared COVID-19 a pandemic on 11 March 2020 [ 2 ]. Furthermore, on 14 April 2020, it was confirmed that up to 210 countries and territories were affected, with more than 1,900,000 SARS-CoV-2 cases worldwide and more than 110,000 deaths [ 1 ]. By March 2021, there were 118.5 M cases confirmed COVID-19 cases and 2.64 M deaths worldwide.…”

Section: Introductionmentioning

confidence: 99%

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Impact on Visual Acuity in Neovascular Age Related Macular Degeneration (nAMD) in Europe Due to COVID-19 Pandemic Lockdown

Arruabarrena

Toro

Önen

et al. 2021

JCM

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This is a retrospective, multicenter study of consecutive patients with nAMD scheduled for a visit and/or a treatment with an intravitreal injection (IVI) during the 3 months before lockdown in the Ophthalmology Departments of six centers of Europe.The study was conducted on 546 patients, of which 55.13% were females, almost 100% of the patients were White/Caucasian race, and 71.53% of the patients presented a type 1 macular neovascularization (NVM). A total of 62.82% of patients (343 patients) that were on scheduled clinic visits and/or intravitreal injection treatment during the 3 months before the quarantine did not attend either to visit or for treatment during the lockdown. The mean number of injections during the lockdown was significantly reduced. This was followed by a significant reduction in the mean best-corrected visual acuity (BCVA) between the 3 months before the lockdown (mean BCVA of 60.68 ± 19.77 letters) and 6 months after lockdown (mean BCVA of 56.98 ± 22.59 letters). Patients with better BCVA before the lockdown and the ones showing neovascular activity were more likely to attend their scheduled visits and/or IVI treatments. The COVID-19 pandemic and the lockdown have led to a decrease in the number of IVI treatments in patients with nAMD, evidencing a significant vision loss at 6 months.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact on Visual Acuity in Neovascular Age Related Macular Degeneration (nAMD) in Europe Due to COVID-19 Pandemic Lockdown

Arruabarrena

Toro

Önen

et al. 2021

JCM

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“…2 The manpower shortage would be further burdened by the aging population, made worse by the COVID-19 pandemic crisis started since 2020. 5 , 6 Where are we now with the declaration of war on diabetes and diabetic retinopathy? 7 What about the growing burden of age-related macular degeneration with the aging population?…”

mentioning

confidence: 99%

Augmented Intelligence in Ophthalmology: The Six Rights

Ting

Al-Aswad

2021

Asia-Pacific Journal of Ophthalmology

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“…[5][6][7] Moreover, we are still in the middle of the COVID-19 pandemic, in which we have to make a number of adjustments in our ophthalmic practice and daily living. [8][9][10] The overuse of the eye with digital screens is more prominent in the pandemic and has caused harmful effects to the eye. 11,12 The potentially damaging effects on the eye from the blue light emitted from the digital screens has become a topic of great importance.…”

mentioning

confidence: 99%

Potential Protective Role of TRPM7 and Involvement of PKC/ERK Pathway in Blue Light–Induced Apoptosis in Retinal Pigment Epithelium Cells in Vitro

2021

Asia-Pacific Journal of Ophthalmology

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Purpose: Blue light triggers apoptosis of retinal pigment epithelium (RPE) cells and causes retinal damage. The aim of this study was to elucidate the protective role of transient receptor potential melastatin 7 (TRPM7) in photodamaged RPE cells. Methods: RPE cells were isolated from Sprague-Dawley (SD) rats and exposed to varying intensities of blue light (500–5000 lux) in vitro. Cell proliferation and metabolic activity were respectively assessed by bromodeoxyuridine (BrdU) incorporation and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assays. Real-time polymerase chain reaction (RT-PCR) and western blotting were used to analyze the TRPM7, protein kinase C (PKC), extracellular signal-regulated kinase (ERK) and Bcl2-associated x/B-cell lymphoma 2 (Bax/Bcl-2) messenger RNA (mRNA) and protein expression levels. The cells were transfected with TRPM7 small interfering RNA (siRNA) or transduced with TRPM7-overexpressing lentiviruses and cultured with or without the pigment epithelium-derived factor (PEDF). Results: Blue light inhibited the proliferation and metabolic activity of RPE cells in an intensity-dependent manner when compared to nonirradiated controls ( P < 0.05). Compared to the control, photodamaged RPE cells showed decreased levels of TRPM7, PKC, ERK, and Bax, and an increase in Bcl-2 levels ( P < 0.01). Forced expression of TRPM7 partially rescued the proliferative capacity of RPE cells ( P < 0.01) and restored the levels of TRPM7, PKC, ERK, and Bax ( P < 0.01), whereas TRPM7 knockdown had the opposite effects ( P < 0.01). TRPM7 and PEDF synergistically alleviated the damaging effects of blue light. Conclusions: Blue light triggers apoptosis of RPE cells, and its deleterious effects can be partially attenuated by the synergistic action of TRPM7 and PEDF via the PKC/ERK signaling pathway.

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COVID-19 Pandemic: Ways Forward

Cited by 7 publications

References 5 publications

Impact on Visual Acuity in Neovascular Age Related Macular Degeneration (nAMD) in Europe Due to COVID-19 Pandemic Lockdown

Impact on Visual Acuity in Neovascular Age Related Macular Degeneration (nAMD) in Europe Due to COVID-19 Pandemic Lockdown

Augmented Intelligence in Ophthalmology: The Six Rights

Potential Protective Role of TRPM7 and Involvement of PKC/ERK Pathway in Blue Light–Induced Apoptosis in Retinal Pigment Epithelium Cells in Vitro

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