COVID-19 Patient with Multifocal Pneumonia and Respiratory Difficulty Resolved Quickly: Possible Antiviral and Anti-Inflammatory Benefits of Quercinex (Nebulized Quercetin-NAC) as Adjuvant

Potential use of polyphenols in the battle against COVID-19

“…Another point that should be taken into account is the proper formulation for these polyphenol-based nutraceuticals. To counteract low bioavailability concerns and increase concentrations of active polyphenols in the respiratory tract, the primary site of infection, using aerosol delivery systems, such as nebulizers and inhalers should be considered [ 66 • , 70 ].…”

“…Pudilan Xiaoyan Oral Liquid (PDL), a traditional Chinese medicine containing four herbs and more than 180 ingredients exhibited potent anti-SARS-CoV-2 activity in infected hACE2 mice [ 65 • ]. It was also reported that a nebulized formula of quercetin and N-acetylcysteine greatly alleviated SARS-CoV-2 respiratory symptoms in a patient treated with hydroxychloroquine and antibiotics [ 66 • ]. This confirms the importance of further clinical studies to evaluate the potential of polyphenol-based nutraceuticals as adjuvant or main therapy for COVID-19.…”

Polyphenols as promising biologically active substances for preventing SARS-CoV-2: A review with research evidence and underlying mechanisms

“…Pudilan Xiaoyan Oral Liquid (PDL), a traditional Chinese medicine containing four herbs and more than 180 ingredients, showed potent anti-SARSCoV-2 activity in infected hACE2 mice ( Deng et al , 2020 ). It has also been stated that a nebulized formula of quercetin and N-acetylcysteine substantially relieved the respiratory symptoms of SARS-CoV-2 in a patient treated with hydroxychloroquine and antibiotics ( Schettig et al , 2020 ). This reinforces the value of more clinical trials to determine the potential of polyphenol-based nutraceuticals as an adjuvant or key treatment for COVID-19.…”

A Review on the Antiviral Activity of Functional Foods Against COVID-19 and Viral Respiratory Tract Infections

“… 95 , 96 Moreover, flavonoids could relieve the respiratory symptoms of COVID-19 in the case of individuals managed with hydroxychloroquine. 97 In addition, the use of combination curcumin and Zn have also been proposed to modulate the immune system to combat coronavirus infections. 98 However, as potent anti-inflammatory agents, flavonoids are valuable biomarkers for assessing human health.…”