COVID-19 pneumonia: computer-aided quantification of healthy lung parenchyma, emphysema, ground glass and consolidation on chest computed tomography (CT)

Grassi, Roberta; Belfiore, Maria Paola; Montanelli, Alessandro; Patelli, Gianluigi; Urraro, Fabrizio; Giacobbe, Giuliana; Fusco, Roberta; Granata, Vincenza; Petrillo, Antonella; Sacco, Palmino; Mazzei, Maria Antonietta; Feragalli, Beatrice; Reginelli, Alfonso; Cappabianca, Salvatore

doi:10.1007/s11547-020-01305-9

Cited by 48 publications

(39 citation statements)

References 42 publications

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“…Because these events are rare, and COVID-19 itself often causes blood clotting disorders in patients, it is difficult to estimate a background rate for these events in people who have not had the vaccine. In fact, besides the respiratory manifestations with severe disabling complications, another major concern is represented by evidence of consistent hemostatic changes in patients with severe or critical COVID-19, likely related to a pro-thrombotic switch [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ]. Among COVID-19 patients, it is reasonable to assume that those with a very severe disease could exhibit high risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and/or pulmonary embolism (PE) [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Cerebral Venous Thrombosis and Disseminated Intravascular Coagulation Temporally Associated to the COVID-19 Vaccine Administration

D’Agostino¹,

Caranci

Negro³

et al. 2021

JPM

Self Cite

103

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Globally, at the time of writing (20 March 2021), 121.759.109 confirmed COVID-19 cases have been reported to the WHO, including 2.690.731 deaths. Globally, on 18 March 2021, a total of 364.184.603 vaccine doses have been administered. In Italy, 3.306.711 confirmed COVID-19 cases with 103.855 deaths have been reported to WHO. In Italy, on 9 March 2021, a total of 6.634.450 vaccine doses have been administered. On 15 March 2021, Italian Medicines Agency (AIFA) decided to temporarily suspend the use of the AstraZeneca COVID-19 vaccine throughout the country as a precaution, pending the rulings of the European Medicines Agency (EMA). This decision was taken in line with similar measures adopted by other European countries due to the death of vaccinated people. On 18 March 2021, EMA’s safety committee concluded its preliminary review about thromboembolic events in people vaccinated with COVID-19 Vaccine AstraZeneca at its extraordinary meeting, confirming the benefits of the vaccine continue to outweigh the risk of side effects, however, the vaccine may be associated with very rare cases of blood clots associated with thrombocytopenia, i.e., low levels of blood platelets with or without bleeding, including rare cases of cerebral venous thrombosis (CVT). We report the case of a 54-year-old woman who developed disseminated intravascular coagulation (DIC) with multi-district thrombosis 12 days after the AstraZeneca COVID-19 vaccine administration. A brain computed tomography (CT) scan showed multiple subacute intra-axial hemorrhages in atypical locations, including the right frontal and the temporal lobes. A plain old balloon angioplasty (POBA) of the right coronary artery was performed, without stent implantation, with restoration of distal flow, but with persistence of extensive thrombosis of the vessel. A successive thorax angio-CT added the findings of multiple contrast filling defects with multi-vessel involvement: at the level of the left upper lobe segmental branches, of left interlobar artery, of the right middle lobe segmental branches and of the right interlobar artery. A brain magnetic resonance imaging (MRI) in the same day showed the presence of an acute basilar thrombosis associated with the superior sagittal sinus thrombosis. An abdomen angio-CT showed filling defects at the level of left portal branch and at the level of right suprahepatic vein. Bilaterally, it was adrenal hemorrhage and blood in the pelvis. An evaluation of coagulation factors did not show genetic alterations so as the nasopharyngeal swab ruled out a COVID-19 infection. The patient died after 5 days of hospitalization in intensive care.

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Section: Discussionmentioning

confidence: 99%

A Rare Case of Cerebral Venous Thrombosis and Disseminated Intravascular Coagulation Temporally Associated to the COVID-19 Vaccine Administration

D’Agostino¹,

Caranci

Negro³

et al. 2021

JPM

Self Cite

103

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“…This new coronavirus causes a highly infectious disease, commonly called Coronavirus disease 2019 (COVID-19) [11][12][13][14][15][16][17]. The COVID-19 pneumonia is defined as one of the "greatest radiological mimickers" because of the various diseases it may be confused with [18][19][20][21][22][23]. Typical HRCT pattern in the acute phase of COVID-19 is characterized by the presence of peripheral, subpleural, bilateral, and basal GGOs and consolidations, in some cases also with a super-imposed interlobular/ intralobular septal thickening (the so-called "crazy-paving" pattern) (Fig.…”

Section: Introductionmentioning

confidence: 99%

Ground-glass opacity (GGO): a review of the differential diagnosis in the era of COVID-19

et al. 2021

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“…Recent results have revealed the efficiency of some imaging methods, including chest radiographs and chest computed tomography scans, in the management of COVID-19 disease [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ]. Instead, at the best of our knowledge, this is the first paper describing the appearance of nodes after BNT162b2 Covid-19 vaccine.…”

Section: Discussionmentioning

confidence: 99%

Lymphadenopathy after BNT162b2 Covid-19 Vaccine: Preliminary Ultrasound Findings

Granata

Fusco

Setola

et al. 2021

Biology

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During a spontaneous and autonomous study, we assessed the ultrasound finding of lymphadenopathy after BNT162b2 Pfizer vaccine. We enrolled 18 patients with 58 lymphadenopathies: in 10 patients, they were in the laterocervical side, while in 8 patients in the axillar site. The largest diameter was 14 mm with a range from 7 to 16 mm (median value = 10 mm). In the same patient, we found different ultrasound nodal findings. A total of 25 nodes showed eccentric cortical thickening with wide echogenic hilum and oval shape. In total, 19 nodes showed asymmetric eccentric cortical thickening with wide echogenic hilum and oval shape. Overall, 10 nodes showed concentric cortical thickening with reduction in the width of the echogenic hilum and oval shape. A total of four nodes showed huge reduction and displacement of the echogenic hilum and round or oval shape. No anomaly was found at the Doppler echocolor study. In conclusion, eccentric cortical thickening with wide echogenic hilum and oval shape, asymmetric eccentric cortical thickening with wide echogenic hilum and oval shape, concentric cortical thickening with reduction in the width of the echogenic hilum and oval shape, and a huge reduction and displacement of the echogenic hilum and round shape are the features that we found in post BNT162b2 Covid-19 Vaccine lymphadenopathies.

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COVID-19 pneumonia: computer-aided quantification of healthy lung parenchyma, emphysema, ground glass and consolidation on chest computed tomography (CT)

Cited by 48 publications

References 42 publications

A Rare Case of Cerebral Venous Thrombosis and Disseminated Intravascular Coagulation Temporally Associated to the COVID-19 Vaccine Administration

A Rare Case of Cerebral Venous Thrombosis and Disseminated Intravascular Coagulation Temporally Associated to the COVID-19 Vaccine Administration

Ground-glass opacity (GGO): a review of the differential diagnosis in the era of COVID-19

Lymphadenopathy after BNT162b2 Covid-19 Vaccine: Preliminary Ultrasound Findings

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