Covid-19, prise en charge, pistes thérapeutiques et vaccinales

Matusik, Elodie; Ayadi, M.; Picard, Nicolas

doi:10.1016/j.actpha.2020.08.007

Cited by 4 publications

(2 citation statements)

References 35 publications

(31 reference statements)

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“…In addition, suppose that chloroquine and hydroxychloroquine have clinical e cacy in combating Sars-Cov-2. We checked its mechanism of action in previous studies to nd a link to this review (22). These two treatments leaded to eliminate the glycosylation of ACE2 which is necessary for binding with the viral protein S (23).…”

Section: Discussionmentioning

confidence: 99%

“…These two treatments leaded to eliminate the glycosylation of ACE2 which is necessary for binding with the viral protein S (23). Theoretically, chloroquine and hydroxychloroquine played a role in the improvement of some cases and it reinforces that the level of ACE2 was essential for the attack of the virus and the degree of pathogenicity (22). Many therapeutic trials were effectuated to nd the treatment of the disease.…”

Section: Discussionmentioning

confidence: 99%

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COVID 19: The Lack of ACE2 Provides Protection for Children

Temedda

2021

Preprint

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Background In early December 2019, in China the novel severe acute respiratory syndrome coronavirus 2 has been spreading. It was reported that the number of children was lower than adults and they have fewer symptoms. Method Published articles were searched in PubMed, Science direct, in the end 60 articles were collected.Findings Three major findings were found after researching. First, The minority of cases in children category. Secondly, ACE2 resulting penetration in cells after the interaction with virus. And third, a poor presence of ACE2 in lungs children.Discussion Molecularly, the link between the virus and ACE2 was explained, through a segment of viral protein S, comprising four residues nested in RBD. The outbreak due to Sars-Cov-1 has shown that the highest attack rate in China was aged between 20 and 39 (53%).Also, there was a decrease in mortality and severity of diagnosis for patients on ACE inhibitors. It causes a decrease in ACE2 levels. In addition, patients with severe diagnostics are diabetic which lead to the excessive expression of ACE2 in human tissues.Conclusion the ACE2 factor was the aim of our study, but researchers can find many factors linked to the physiology of children.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

COVID 19: The Lack of ACE2 Provides Protection for Children

Temedda

2021

Preprint

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COVID-19 and Service Provisions at Darou Khoudous Health Center of Touba

Sow,

Diop,

Gueye

et al. 2024

WJPH

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Introduction: The objective is to study the consequences of COVID-19 on service provision at the Serigne Mbacke Madina health center in Darou Khoudous in the Touba district. Materials and methods: To achieve this objective, a retrospective, descriptive study was conducted from July 2021 to December 2021. Results: Over the period 2016-2020, the age group 50-59 years and 60 years and over rarely attended the health structure. This low attendance at the health structure was further accentuated in 2020. According to consultation by service: We note that General Medicine, TRI and On-call are quite busy over the period with a significant drop in these consultations within these services in 2020. Indeed, General Medicine went from 37,378 patients in 2017 to 22,332 patients in 2020, i.e. 40%, TRI went from 35,461 patients in 2017 to 26,080 patients in 2020, i.e. 26.45%, and On-call went from 21,880 patients to 12,008 patients in 2020, i.e. 45.11%. Between 2019 and 2020 in Medicine we noted a decrease of 27.84%, in TRI a decrease of 27.8%. For patients followed for HIV at the Darou Khoudous health center, we noticed an almost complete absence of the 0-14 age group. We also noticed a low rate of new cases before 2018 and a sharp drop in the rate of new cases in 2020, a decrease of 87.84% compared to 2019. For tuberculosis patients followed in the department, we noted a strong impact on the age group >15 years, more accentuated between 15 and 35 years over the period 2016-2020. For this same age group, we also noticed a decrease in cases between 2019 and 2020, a decrease of 10%. In 2018 we also noticed a peak in cases compared to the previous 2 years. According to the EPI: variations are almost non-existent during the pandemic, on the contrary, attendances have increased since 2016, this would surely be due to awareness of the beneficial effects of EPI vaccines and that the disease initially only affected the elderly, rare are the cases of children reported. Conclusion: The data collected as part of this study show that the COVID-19 pandemic has disrupted health services and put intolerable pressure on health systems and their staff. We urgently need to reverse this trend and strengthen the resilience of health systems.

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SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

Rabaan

Al-Ahmed

Sah

et al. 2020

Ann Clin Microbiol Antimicrob

110

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A novel coronavirus (SARS-CoV-2), causing an emerging coronavirus disease (COVID-19), first detected in Wuhan City, Hubei Province, China, which has taken a catastrophic turn with high toll rates in China and subsequently spreading across the globe. The rapid spread of this virus to more than 210 countries while affecting more than 25 million people and causing more than 843,000 human deaths, it has resulted in a pandemic situation in the world. The SARS-CoV-2 virus belongs to the genus Betacoronavirus, like MERS-CoV and SARS-CoV, all of which originated in bats. It is highly contagious, causing symptoms like fever, dyspnea, asthenia and pneumonia, thrombocytopenia, and the severely infected patients succumb to the disease. Coronaviruses (CoVs) among all known RNA viruses have the largest genomes ranging from 26 to 32 kb in length. Extensive research has been conducted to understand the molecular basis of the SARS-CoV-2 infection and evolution, develop effective therapeutics, antiviral drugs, and vaccines, and to design rapid and confirmatory viral diagnostics as well as adopt appropriate prevention and control strategies. To date, August 30, 2020, no effective, proven therapeutic antibodies or specific drugs, and vaccines have turned up. In this review article, we describe the underlying molecular organization and phylogenetic analysis of the coronaviruses, including the SARS-CoV-2, and recent advances in diagnosis and vaccine development in brief and focusing mainly on developing potential therapeutic options that can be explored to manage this pandemic virus infection, which would help in valid countering of COVID-19.

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Covid-19, prise en charge, pistes thérapeutiques et vaccinales

Cited by 4 publications

References 35 publications

COVID 19: The Lack of ACE2 Provides Protection for Children

COVID 19: The Lack of ACE2 Provides Protection for Children

COVID-19 and Service Provisions at Darou Khoudous Health Center of Touba

SARS-CoV-2/COVID-19 and advances in developing potential therapeutics and vaccines to counter this emerging pandemic

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