On June 12, 2020, this report was posted as an MMWR Early Release on the MMWR website (https://www.cdc.gov/mmwr). SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), is thought to be transmitted mainly by person-toperson contact (1). Implementation of nationwide public health orders to limit person-to-person interaction and of guidance on personal protective practices can slow transmission (2,3). Such strategies can include stay-at-home orders, business closures, prohibitions against mass gatherings, use of cloth face coverings, and maintenance of a physical distance between persons (2,3). To assess and understand public attitudes, behaviors, and beliefs related to this guidance and COVID-19, representative panel surveys were conducted among adults aged ≥18 years in New York City (NYC) and Los Angeles, and broadly across the United States during May 5-12, 2020. Most respondents in the three cohorts supported stay-at-home orders and nonessential business closures* (United States, 79.5%; New York City, 86.7%; and Los Angeles, 81.5%), reported always or often wearing cloth face coverings in public areas (United States, 74.1%, New York City, 89.6%; and Los Angeles 89.8%), and believed that their state's restrictions were the right balance or not restrictive enough (United States, 84.3%; New York City, 89.7%; and Los Angeles, 79.7%). Periodic assessments of public attitudes, behaviors, and beliefs can guide evidence-based public health decision-making and related prevention messaging about mitigation strategies needed as the COVID-19 pandemic evolves. During May 5-12, 2020, a total of 4,042 adults aged ≥18 years in the United States were invited to complete a web-based survey administered by Qualtrics, LLC. † Surveys were conducted among residents of NYC and Los Angeles to enable comparison of the two most populous cities in the United States with each * Respondents were informed that, for the survey, stay-at-home orders mean that all nonessential services (e.g., dine-in restaurants, bars, social venues, gyms, fitness studios, and convention centers) are shut down. Essential services (e.g., groceries, pharmacies, gas stations, food banks, convenience stores, and delivery restaurants) remain open. Banks, local governments, and law enforcement agencies also remain open. Persons are still allowed to leave their homes but encouraged to observe social distancing guidelines. Public events and gatherings are not allowed. † Eligibility for the nationwide U.S. cohort was determined on the basis of informed consent, age, and residence within the United States. Therefore, consented adult potential respondents residing in NYC and Los Angeles metro areas were eligible to complete surveys as part of the nationwide U.S. or NYC and Los Angeles cohorts. * Nationwide cohort (n = 1,676) only unless otherwise specified. The six respondent characteristic categories shown in the table (gender, age, ethnicity, race, employment status, and essential worker status) account for 32 of 34 significant associations among the 108...