COVID‐19 reinfection or reactivation in a renal transplant patient

Abolghasemi, Sara; Zolfaghari, Farnaz; Naeimipoor, Mohammad; Tehrani, Hamed Azhdari; Hakamifard, Atousa

doi:10.1002/ccr3.4672

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…In addition, recurrences of COVID-19 infection may occur in these patients that potentially can be an additional risk for severe COVID-19 and related complications. [75][76][77]…”

Section: Comorbid Conditionsmentioning

confidence: 99%

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COVID‐19 associated mucormycosis surge: A review on multi‐pathway mechanisms

Pourazizi,

Hakamifard,

Peyman

et al. 2023

Parasite Immunology

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Mucormycosis is a fungal infection caused by moulds from the Mucorales order. Concerns have been mounting due to the alarming increase in severe morbidity and mortality associated with mucormycosis during the COVID‐19 pandemic. This condition, known as COVID‐19‐associated mucormycosis (CAM), has been linked to various environmental, host‐related, and medical factors on a global scale. We have categorized the most significant potential risk factors for developing mucormycosis in individuals with a previous history of coronavirus infection into 10 major categories. These categories include acute hyperglycemia, the impact of cytokine release, immune response deficiencies in COVID‐19 patients, microvasculopathy and dysfunction of endothelial cells, imbalances in iron metabolism, metabolic acidosis, organ damage resulting from COVID‐19, underlying health conditions (such as diabetes), environmental factors, and medical treatments that can be iatrogenic in nature (such as inappropriate glucocorticoid use). Many of these factors can lead to potentially life‐threatening infections that can complicate the treatment of COVID‐19. Physicians should be vigilant about these factors because early detection of mucormycosis is crucial for effective management of this condition.

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“…In addition, recurrences of COVID-19 infection may occur in these patients that potentially can be an additional risk for severe COVID-19 and related complications. [75][76][77]…”

Section: Comorbid Conditionsmentioning

confidence: 99%

“…These patients are particularly at risk due to their immunosuppression, subsequent immune deficiency, and coexistence of comorbidities. In addition, recurrences of COVID‐19 infection may occur in these patients that potentially can be an additional risk for severe COVID‐19 and related complications 75–77 …”

Section: Risk Factorsmentioning

confidence: 99%

COVID‐19 associated mucormycosis surge: A review on multi‐pathway mechanisms

Pourazizi,

Hakamifard,

Peyman

et al. 2023

Parasite Immunology

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Ciclosporin/mycophenolate-mofetil/prednisolone

2022

Reactions Weekly

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Chronic COVID-19 infection in an immunosuppressed patient shows changes in lineage over time: a case report

Baker,

Nfonsam,

Leto

et al. 2024

Virol J

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Background The COVID-19 pandemic, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 virus, emerged in late 2019 and spready globally. Many effects of infection with this pathogen are still unknown, with both chronic and repeated COVID-19 infection producing novel pathologies. Case presentation An immunocompromised patient presented with chronic COVID-19 infection. The patient had history of Hodgkin’s lymphoma, treated with chemotherapy and stem cell transplant. During the course of their treatment, eleven respiratory samples from the patient were analyzed by whole-genome sequencing followed by lineage identification. Whole-genome sequencing of the virus present in the patient over time revealed that the patient at various timepoints harboured three different lineages of the virus. The patient was initially infected with the B.1.1.176 lineage before coinfection with BA.1. When the patient was coinfected with both B.1.1.176 and BA.1, the viral populations were found in approximately equal proportions within the patient based on sequencing read abundance. Upon further sampling, the lineage present within the patient during the final two timepoints was found to be BA.2.9. The patient eventually developed respiratory failure and died. Conclusions This case study shows an example of the changes that can happen within an immunocompromised patient who is infected with COVID-19 multiple times. Furthermore, this case demonstrates how simultaneous coinfection with two lineages of COVID-19 can lead to unclear lineage assignment by standard methods, which are resolved by further investigation. When analyzing chronic COVID-19 infection and reinfection cases, care must be taken to properly identify the lineages of the virus present.

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COVID‐19 reinfection or reactivation in a renal transplant patient

Abstract: Recurrences of COVID‐19 infection may occur in immunocompromised patients. Reinfection or reactivation of COVID‐19 virus is a challenging issue in these patients.

Cited by 3 publications

References 19 publications

COVID‐19 associated mucormycosis surge: A review on multi‐pathway mechanisms

COVID‐19 associated mucormycosis surge: A review on multi‐pathway mechanisms

Ciclosporin/mycophenolate-mofetil/prednisolone

Chronic COVID-19 infection in an immunosuppressed patient shows changes in lineage over time: a case report

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