COVID-19-related cholecystitis

Famularo, Giuseppe; Spada, Pier Luigi

doi:10.1016/j.clinre.2021.101635

Cited by 5 publications

(6 citation statements)

References 13 publications

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“…Regarding the treatment of acute cholecystitis, some authors reported the treatment with antibiotics[ 46 ], others reported percutaneous cholecystostomy[ 16 , 26 ], and others published their outcomes after laparoscopic or open cholecystectomy[ 46 , 47 ] (Table 4 ). The relevance of our study is that we described the outcomes of 10 patients with positive COVID-19 tests who required urgent cholecystectomy.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of acute cholecystitis in patients with confirmed COVID-19: Ten case reports and review of literature

Bozada‐Gutiérrez¹,

Trejo-Ávila²,

Chávez-Hernández³

et al. 2022

WJCC

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BACKGROUND Research concerning postoperative outcomes of confirmed coronavirus disease 2019 (COVID-19) patients revealed unfavorable postoperative results with increased morbidity, pulmonary complications and mortality. Case reports have suggested that COVID-19 is associated with more aggressive presentation of acute cholecystitis. The aim of the present study is to describe the perioperative assessment and postoperative outcomes of ten patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with concomitant acute cholecystitis who underwent cholecystectomy. CASE SUMMARY We report a total of 10 SARS-CoV-2 positive patients with concomitant acute cholecystitis that underwent cholecystectomy. Six patients were males, the mean age was 47.1 years. Nine patients had moderate acute cholecystitis, and one patient had severe acute cholecystitis. All patients were treated with urgent/early laparoscopic cholecystectomy. Regarding the Parkland grading scale, two patients received a Parkland grade of 3, two patients received a Parkland grade of 4, and six patients received a Parkland grade of 5. Eight patients required a bail-out procedure. Four patients developed biliary leakage and required endoscopic retrograde cholangiopancreatography with biliary sphincterotomy. After surgery, five patients developed acute respiratory distress syndrome (ARDS) and required intensive care unit (ICU) admission. One patient died after cholecystectomy due to ARDS complications. The mean total length of stay (LOS) was 18.2 d. The histopathology demonstrated transmural necrosis ( n = 5), vessel obliteration with ischemia ( n = 3), perforation ( n = 3), and acute peritonitis ( n = 10). CONCLUSION COVID-19 patients with acute cholecystitis had difficult cholecystectomies, high rates of ICU admission, and a prolonged LOS.

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Section: Discussionmentioning

confidence: 99%

Surgical treatment of acute cholecystitis in patients with confirmed COVID-19: Ten case reports and review of literature

Bozada‐Gutiérrez¹,

Trejo-Ávila²,

Chávez-Hernández³

et al. 2022

WJCC

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“…The detection of viral RNA in the bile wall and gallbladder further supports this hypothesis. Other possible mechanisms include inflammation due to cytokine release syndrome, ischemia due to hypercoagulability, and thrombotic microangiopathy due to SARS-CoV-2 infection [ 19 , 20 , 21 , 22 , 23 ]. However, all the aforementioned findings are just hypotheses of a possible relationship between COVID-19 and AAC, since there are no large studies with robust data supporting a definite causal relationship between these two pathologies.…”

Section: Biliary Manifestations Of Covid-19mentioning

confidence: 99%

Acalculous Cholecystitis in COVID-19 Patients: A Narrative Review

Thomaidou,

Karlafti,

Didagelos

et al. 2024

Viruses

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Acute acalculous cholecystitis (AAC) represents cholecystitis without gallstones, occurring in approximately 5–10% of all cases of acute cholecystitis in adults. Several risk factors have been recognized, while infectious diseases can be a cause of cholecystitis in otherwise healthy people. Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has spread worldwide, leading to an unprecedented pandemic. The virus enters cells through the binding of the spike protein to angiotensin-converting enzyme 2 (ACE2) receptors expressed in many human tissues, including the epithelial cells of the gastrointestinal (GI) tract, and this explains the symptoms emanating from the digestive system. Acute cholecystitis has been reported in patients with COVID-19. The purpose of this review is to provide a detailed analysis of the current literature on the pathogenesis, diagnosis, management, and outcomes of AAC in patients with COVID-19.

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“…Detection of viral RNA in bile and gall bladder wall further supports this speculation. Other possible mechanism includes inflammation from cytokine release syndrome, ischemia from hypercoagulability, and thrombotic microangiopathy secondary to SARS-CoV-2 infection [69,[71][72]74].…”

Section: Biliary Manifestations Of Covid-19mentioning

confidence: 99%

Impact of COVID-19 on the Gastrointestinal Tract: A Clinical Review

Ghazanfar¹,

Kandhi²,

Shin³

et al. 2022

Cureus

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Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world, causing a pandemic that has resulted in more than 5 million deaths globally. The gastrointestinal (GI) tract is known to have high expression of angiotensin-converting enzyme 2 (ACE2) receptors in the human body, making it prone to direct damage from the cellular invasion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Numerous GI symptoms have been reported among patients with COVID-19. This systemic review details the mechanism and effects of COVID-19 on the GI tract along with the hepatobiliary and pancreatic systems.

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COVID-19-related cholecystitis

Cited by 5 publications

References 13 publications

Surgical treatment of acute cholecystitis in patients with confirmed COVID-19: Ten case reports and review of literature

Surgical treatment of acute cholecystitis in patients with confirmed COVID-19: Ten case reports and review of literature

Acalculous Cholecystitis in COVID-19 Patients: A Narrative Review

Impact of COVID-19 on the Gastrointestinal Tract: A Clinical Review

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