Background and Objectives: During the COVID-19 pandemic, Chinese international students(CISs) experienced increased depression and anxiety associated with a combination of unique and universal COVID-19-related stressors. Among these factors, discrimination against Chinese is especially alarming. Therefore, studying correlates of distress including the association between discrimination and distress and factors intensifying or attenuating this link has important implications.Design: We adopted a cross-sectional self-report design.Methods: Our study compared depression and anxiety between CISs (N = 381) and Chinese students in Chinese colleges (CSCCs; N = 306) and examined correlates of distress and, in particular, the association between perceived discrimination and distress as well as moderators on this link within CISs.Results: Compared to CSCCs, CISs reported greater depression and anxiety. Depression was associated with being female, older, non-heterosexual, discrimination, coping inflexibility, low social support, and low satisfaction with online learning. Anxiety was associated with being female, older, heterosexual, discrimination, coping inflexibility, low social support, and low satisfaction with online learning. High perceived social support and being heterosexual weakened the association between discrimination and distress (anxiety and depression). Conclusions: Our study underscored the impact of the pandemic and related discrimination on CISs and highlighted individual differences that may warrant attention.Keywords: COVID-19, Chinese international students, psychopathology, perceived discrimination, intersectionality, minority stress