COVID-19 research in critical care: the good, the bad, and the ugly

Salluh, Jorge I.; Arabi, Yaseen M.; Binnie, Alexandra

doi:10.1007/s00134-021-06367-5

Cited by 16 publications

(14 citation statements)

References 19 publications

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“…It can, therefore, be expected that COVID-19 will remain a continued challenge in ICUs globally for some time to come. Efforts to study the disease should continue to advance our understanding of the disease and improve patient management and treatment [6].…”

Section: Introductionmentioning

confidence: 99%

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study

Greco

Corte²,

Ercole³

et al. 2022

Intensive Care Med

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Purpose: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients.Methods: Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020.Results: 4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%-50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors.

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Section: Introductionmentioning

confidence: 99%

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study

Greco

Corte²,

Ercole³

et al. 2022

Intensive Care Med

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“…The overwhelming urgency of the COVID-19 pandemic has led to many publications and various hypotheses based on limited evidence [15] with an overall quality that is below the pre-pandemic level (Supplementary reference). Data on the role of GI tract in COVID-19 are no exception, calling for the need for well conducted studies addressing this important topic.…”

Section: Gi Dysfunction In Severe Covid-19 Vs Other Critical Illnessesmentioning

confidence: 99%

The gut in COVID-19

2021

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“…COVID-19 research during the pandemic has been challenging, there are many underpowered or duplicated studies with inconclusive results [398]. This is compounded by an "infodemic" of poor-quality medical information [399].…”

Section: Quality Of Covid-19 Publicationsmentioning

confidence: 99%

Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19

Udovičić

Stanojević

Djordjević

et al. 2021

JCM

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Immune cells and mediators play a crucial role in the critical care setting but are understudied. This review explores the concept of sepsis and/or injury-induced immunosuppression and immuno-inflammatory response in COVID-19 and reiterates the need for more accurate functional immunomonitoring of monocyte and neutrophil function in these critically ill patients. in addition, the feasibility of circulating and cell-surface immune biomarkers as predictors of infection and/or outcome in critically ill patients is explored. It is clear that, for critically ill, one size does not fit all and that immune phenotyping of critically ill patients may allow the development of a more personalized approach with tailored immunotherapy for the specific patient. In addition, at this point in time, caution is advised regarding the quality of evidence of some COVID-19 studies in the literature.

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COVID-19 research in critical care: the good, the bad, and the ugly

Cited by 16 publications

References 19 publications

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study

Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study

The gut in COVID-19

Immunomonitoring of Monocyte and Neutrophil Function in Critically Ill Patients: From Sepsis and/or Trauma to COVID-19

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