COVID-19: Review and hematologic impact

Toledo, Sílvia Letícia de Oliveira; Nogueira, Leilismara Sousa; Carvalho, Maria das Graças; Rios, Danyelle Romana Alves; Pinheiro, Melina de Barros

doi:10.1016/j.cca.2020.07.016

Cited by 61 publications

(60 citation statements)

References 74 publications

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“…Baseline Ddimer (OR = 3.18 [1.48, 6.82]; p = 0.003), change in fibrinogen (OR = 6.45 [1.31, 31.69]; p = 0.022), and change in platelet count (OR = 0.95 [0.90-0.99]; p = 0.029) correlated with an increased risk of death [44]. Similar findings have been appreciated in other studies as well [45][46][47].…”

Section: Laboratory Findings and Prognostic Implicationsupporting

confidence: 84%

Hematologic disorders associated with COVID-19: a review

et al. 2021

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Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2. Primarily an infection of the lower respiratory tract, it is now well known to cause multisystem abnormalities. Hematologic manifestations constitute a significant area of concern. Severe acute respiratory syndrome coronavirus 2 infects monocytes and endothelial cells leading to a complex downstream cascade, cytokine storm, and eventual intravascular thrombosis. Coronavirus disease 2019 causes lymphopenia, neutrophilia, and thrombocytopenia. Prophylactic anticoagulation is vital in patients with coronavirus disease 2019, as its effect on the coagulation system is associated with significant morbidity and mortality. The disease can cause both arterial and venous thromboses, especially pulmonary embolism and pulmonary microthrombi. A high index of suspicion is indispensable in recognizing these complications, and timely institution of therapeutic anticoagulation is vital in treating them. Virus-induced disseminated intravascular coagulation is uncommon but shares some similarities to sepsis-induced disseminated intravascular coagulation. Marked elevations in hematologic biomarkers such as lactate dehydrogenase, D-dimer, ferritin, and C-reactive protein are associated with worse outcomes. Understanding the pathophysiology and recognizing factors associated with poor prognosis are crucial in improving patient outcomes with coronavirus disease 2019.

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Section: Laboratory Findings and Prognostic Implicationsupporting

confidence: 84%

Hematologic disorders associated with COVID-19: a review

et al. 2021

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“…Although limited patients have been described with serious hemorrhagic complications in the respiratory system, autopsies of those dying from COVID-19 have shown that alveolar hemorrhages are a common finding in those dying and are interestingly accompanied by the inappropriate formation of thrombi [6] . This finding in pathology examination of human tissues could be supplemented with in vitro studies which clearly show a dysfunctional coagulation system and platelet function [7] . Furthermore, autopsies show signs of diffuse alveolar damage with a rich infiltrate of inflammatory cells, which could contribute to damage to small alveolar vessels [ 8 , 9 ].…”

Section: Discussionmentioning

confidence: 91%

Alveolar hemorrhage in the setting of COVID-19: Report of a successful vascular intervention and embolization

Mohammadi¹,

Boroofeh²,

Mousavi-Aghdas³

et al. 2021

Radiology Case Reports

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“…Likewise leukocytosis, neutrophilia and lymphopenia, with high NLR and low platelet count are worst prognostic markers in COVID-19. Increasing scientific research in field of COVID-19, the abnormalities in routine laboratory investigations, particularly the baseline investigation that is complete blood picture, has the potential to indicate the severity of the disease in a quick, easy, affordable, accessible and economical way and can give a way forward for the specific tests for diagnosis and prognosis of the disease [7]. Laboratory abnormalities in hematological indices are used for assessment of homeostasis, in order to know the impact of the COVID-19 on hematopoietic system and homeostasis which significantly suffer in this deadly disease [8].…”

Section: Discussionmentioning

confidence: 99%