COVID-19 signalome: Pathways for SARS-CoV-2 infection and impact on COVID-19 associated comorbidity

Lundström, Kenneth; Hromić‐Jahjefendić, Altijana; Bilajac, Esma; Aljabali, Alaa A. A.; Baralić, Katarina; Sabri, Nagwa A.; Shehata, Eslam Mansour; Raslan, Mohamed; Ferreira, Ana Cláudia Barbosa Honório; Orlandi, Lidiane; Serrano‐Aroca, Ángel; Tambuwala, Murtaza M.; Uversky, Vladimir N.; Azevedo, Vasco; Alzahrani, Khalid J.; Alsharif, Khalaf F.; Halawani, Ibrahim F.; Alzahrani, Fuad M.; Redwan, Elrashdy M.; Barh, Debmalya

doi:10.1016/j.cellsig.2022.110495

Cited by 25 publications

(16 citation statements)

References 179 publications

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“…In contrast to data reported among adult COVID‐19 patients, the CSF protein level of Omicron‐infected children were not significantly increased 14 . This suggests that Omicron may trigger significant inflammation within the brain through activation of intracellular signaling pathways that lead to tissue‐specific cytokine release syndrome 41 . Taken together, our findings suggest that the neurological manifestations in Omicron‐infected pediatric patients are more likely due to immunopathology than direct virus‐induced damage.…”

Section: Discussioncontrasting

confidence: 87%

Clinical characteristics of unvaccinated or incompletely vaccinated children with neurological manifestations due to SARS‐CoV‐2 Omicron infection

Tso

Kwan²,

Kwok

et al. 2023

Journal of Medical Virology

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Omicron generally causes milder disease than previous strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), especially in fully vaccinated individuals. However, incompletely vaccinated children may develop Omicronrelated complications such as those affecting the central nervous system. To characterize the spectrum of clinical manifestations of neuro-COVID and to identify potential biomarkers associated with clinical outcomes, we recruited 15 children hospitalized for Omicron-related neurological manifestations in three hospitals in Hong Kong (9 boys and 6 girls aged 1-13 years). All were unvaccinated or incompletely vaccinated. Fourteen (93.3%) were admitted for convulsion, including

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Section: Discussioncontrasting

confidence: 87%

Clinical characteristics of unvaccinated or incompletely vaccinated children with neurological manifestations due to SARS‐CoV‐2 Omicron infection

Tso

Kwan²,

Kwok

et al. 2023

Journal of Medical Virology

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“…The effect of COVID-19 vaccination on reproductive health and lactation has received plenty of attention [ 25 , 26 , 27 ]. No permanent impact of COVID-19 vaccines on reproduction-related processes such as menstruation, and female and male fertility, except for temporary disturbances in the menstruation cycle and minor drops in sperm counts immediately after vaccinations, have been found in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…In the context of fertility, there has been public concern about COVID-19 vaccines causing female infertility [ 26 ]. This outcry is based on misinformation and erroneous interpretation of data from clinical trials, where pregnancy rates were extremely low due to participants using contraception [ 264 ] or the services of fertility clinics [ 265 ].…”

Section: Effects Of Covid-19 Vaccines On Reproductive Health and Lact...mentioning

confidence: 99%

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Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

et al. 2023

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According to the WHO, as of January 2023, more than 850 million cases and over 6.6 million deaths from COVID-19 have been reported worldwide. Currently, the death rate has been reduced due to the decreased pathogenicity of new SARS-CoV-2 variants, but the major factor in the reduced death rates is the administration of more than 12.8 billion vaccine doses globally. While the COVID-19 vaccines are saving lives, serious side effects have been reported after vaccinations for several premature non-communicable diseases (NCDs). However, the reported adverse events are low in number. The scientific community must investigate the entire spectrum of COVID-19-vaccine-induced complications so that necessary safety measures can be taken, and current vaccines can be re-engineered to avoid or minimize their side effects. We describe in depth severe adverse events for premature metabolic, mental, and neurological disorders; cardiovascular, renal, and autoimmune diseases, and reproductive health issues detected after COVID-19 vaccinations and whether these are causal or incidental. In any case, it has become clear that the benefits of vaccinations outweigh the risks by a large margin. However, pre-existing conditions in vaccinated individuals need to be taken into account in the prevention and treatment of adverse events.

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“…1,2 SARS-CoV-2 signaling is not only associated with COVID-19 severity and mortality, but also contributes to a large number of COVID-19 complications. 3 Several recent systematic reviews and meta-analyses have shown that the low risk of infection and death rates from COVID-19 may be related to serum 25 hydroxyvitamin D (25OHD) concentration. 4,5 It is generally recommended to supplement vitamin D in clinical practice to reduce the damage caused by COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Genetic correlation, causal relationship, and shared loci between vitamin D and COVID‐19: A genome‐wide cross‐trait analysis

Qiu

Zheng

et al. 2023

Journal of Medical Virology

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Observational studies have shown that vitamin D supplementation reduces the risk of COVID-19 infection, yet little is known about the shared genomic architectures between them. Leveraging large-scale genome-wide association study (GWAS) summary statistics, we investigated the genetic correlation and causal relationship between genetically determined vitamin D and COVID-19 using linkage disequilibrium score regression and Mendelian randomization (MR) analyses, and conducted a cross-trait GWAS meta-analysis to identify the overlapping susceptibility loci of them. We observed a significant genetic correlation between genetically predicted vitamin D and COVID-19 (r g = −0.143, p = 0.011), and the risk of COVID-19 infection would decrease by 6% for every 0.76 nmol L −1 increase of serum 25 hydroxyvitamin D (25OHD) concentrations in generalized MR (OR = 0.94, 95% CI: 0.89-0.99, p = 0.019). We identified rs4971066 (EFNA1) as a risk locus for the joint phenotype of vitamin D and COVID-19. In conclusion, genetically determined vitamin D is associated with COVID-19. Increased levels of serum 25OHD concentration may benefit the prevention and treatment of COVID-19.

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COVID-19 signalome: Pathways for SARS-CoV-2 infection and impact on COVID-19 associated comorbidity

Cited by 25 publications

References 179 publications

Clinical characteristics of unvaccinated or incompletely vaccinated children with neurological manifestations due to SARS‐CoV‐2 Omicron infection

Clinical characteristics of unvaccinated or incompletely vaccinated children with neurological manifestations due to SARS‐CoV‐2 Omicron infection

Can COVID-19 Vaccines Induce Premature Non-Communicable Diseases: Where Are We Heading to?

Genetic correlation, causal relationship, and shared loci between vitamin D and COVID‐19: A genome‐wide cross‐trait analysis

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