COVID-19 susceptibility and vaccination coverage for measles, rubella and mumps in students and healthcare workers in Trieste hospitals (NE Italy)

Cattaruzza, Eleonora; Radillo, Lucia; Ronchese, F; Negro, Corrado; Rui, Francesca; Michieli, Paola De; Filon, Francesca Larese

doi:10.1016/j.jvacx.2022.100147

Cited by 1 publication

(2 citation statements)

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“…In contrast to our results and Cattaruzza et al ( 2022 ) results, which showed a direct proportion relationship between COVID-19 severity and the mumps titre, a previous study which reported that only participants with asymptomatic and functionally immune COVID-19 cases had high mumps antibodies titre, and the lower mumps antibodies titre were found in moderate and severe cases. But they could not find the same association between infection with SARS-CoV-2 infection and the rubella antibodies titre.…”

Section: Discussioncontrasting

confidence: 99%

“…Many studies were conducted worldwide to correlate MMR antibodies to the susceptibility and severity to COVID-19 infection. In a recent univariate analysis by Cattaruzza et al ( 2022 ), antibodies were found to be inversely associated with COVID-19 disease with non-significant decrease in its infection. In convalescent COVID-19 infected patients from the USA, a high correlation was discovered between T cell responses to S-SARS-CoV-2 and N-SARS-CoV-2 and MMR antibodies in a study by Mysore et al ( 2021 ).…”

Section: Discussionmentioning

confidence: 94%

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Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?

Salamony

Shamikh

Amer

et al. 2023

Arch. Immunol. Ther. Exp.

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Many factors have been implicated in the pathogenesis and severity of COVID-19 pandemic. A wide variation in the susceptibility for SARS-CoV-2 infection among different population, gender and age has been observed. Multiple studies investigated the relationship between the antibody’s titre of previously vaccinated individuals and the susceptibility of coronavirus infection, to find a rapid effective therapy for this pandemic. This study focused on the association between measles-mumps-rubella (MMR) antibodies titre and the severity of COVID-19 infection. We aimed to investigate the correlation between the antibody’s titre of MMR and the SARS-CoV-2 infection susceptibility and disease severity, in a cohort of COVID-19 Egyptian patients, compared to a control group. MMR antibody titre was measured using enzyme Linked Immune Sorbent Assay; (ELISA) for 136 COVID-19 patients and 44 healthy individuals, as control group. There were high levels of measles and mumps antibodies titer in the deteriorating cases, which could not protect from SARS-CoV-2 infection. However, the rubella antibodies might protect from SARS-CoV-2 infection, but once the infection occurs, it may aggravate the risk of case deterioration. MMR antibodies could be used as a guideline for COVID-19 symptom-severity and, in turn, may be considered as an economic prognostic marker used for early protection from multiple autoimmune organ failure.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 94%