Covid-19: Symptomer, forløp og bruk av kliniske skåringsverktøy hos de 42 første pasientene innlagt på et norsk lokalsykehus

Ihle‐Hansen, Håkon; Berge, Trygve; Tveita, Anders; Rønning, Else Johanne; Ernø, Per Erik; Andersen, Elizabeth Lyster; Wang, Christian Hjorth; Tveit, Arnljot; Myrstad, Marius

doi:10.4045/tidsskr.20.0301

Cited by 35 publications

(32 citation statements)

References 11 publications

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“…Lower blood counts of leukocytes, platelets, neutrophils, lymphocytes, eosinophils, and basophils (all P < 0.001) in COVID-19 patients were significant predictors of SARS-CoV-2 positive test [25]. In addition, compared with less severe diseases, CRP is higher and the lymphocyte count is lower has been found in a study in Norway [26].…”

Section: Reports On Laboratory Indicators Of Covid-19 Patients Worldwmentioning

confidence: 62%

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Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19

Bao

Zhang

et al. 2020

Clinica Chimica Acta

124

103

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Background: The pandemic coronavirus disease 2019 (COVID-19) has threaten the global health. The characteristics of laboratory findings of coronavirus are of great significance for clinical diagnosis and treatment. We found indicators that may most effectively predict a non-severe COVID-19 patient develop into a severe patient. Methods: We conducted a meta-analysis to compare the laboratory findings of severe patients with non-severe patients with COVID-19 from searched articles. Results: Through the analysis of laboratory examination information of patients with COVID-19 from 35 articles (5912 patients), we demonstrated that severe cases possessed higher levels of leukocyte (1.20-fold), neutrophil (1.33-fold), CRP (3.04-fold), PCT (2.00-fold), ESR (1.44-fold), AST (1.40-fold), ALT (1.34-fold), LDH (1.54-fold), CK (1.44-fold), CK-MB (1.39-fold), total bilirubin (1.14-fold), urea (1.28-fold), creatine (1.09-fold), PT (1.03fold) and D-dimer (2.74-fold), as well as lower levels of lymphocytes (1.44-fold), eosinophil (2.00-fold), monocyte (1.08-fold), Hemoglobin (1.53-fold), PLT (1.15-fold), albumin (1.15-fold), and APTT (1.02-fold). Lymphocyte subsets and series of inflammatory cytokines were also different in severe cases with the non-severe ones, including lower levels of CD4 T cells (2.10-fold) and CD8 T cells (2.00-fold), higher levels of IL-1β (1.02fold), IL-6 (1.93-fold) and IL-10 (1.55-fold). Conclusions: Some certain laboratory inspections could predict the progress of the COVID-19 changes, especially lymphocytes, CRP, PCT, ALT, AST, LDH, D-dimer, CD4 T cells and IL6, which provide valuable signals for preventing the deterioration of the disease.

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Section: Reports On Laboratory Indicators Of Covid-19 Patients Worldwmentioning

confidence: 62%

“…Among these articles, 34 articles described the results of blood routine and infection-related biomarkers, 26…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19

Bao

Zhang

et al. 2020

Clinica Chimica Acta

124

103

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“…During the rst weeks of the covid-19 outbreak in Norway, Baerum Hospital was among the hospitals in Norway with the highest rate of admission of covid-19 patients. The methods of the study and preliminary data have been previously published [6].…”

Section: Methodsmentioning

confidence: 99%

National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 - A prospective cohort study

Myrstad

Ihle‐Hansen

Tveita³

et al. 2020

Preprint

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Background There is a need for validated clinical risk scores to identify patients at risk of severe disease and to guide decision-making during the covid-19 pandemic. The National Early Warning Score 2 (NEWS2) is widely used in emergency medicine, but so far, no studies have evaluated its use in patients with covid-19. We aimed to study the performance of NEWS2 and compare commonly used clinical risk stratification tools at admission to predict risk of severe disease and in-hospital mortality in patients with covid-19. Methods This was a prospective cohort study in a public non-university general hospital in the Oslo area, Norway, including a cohort of all 66 patients hospitalised with confirmed SARS-CoV-2 infection from the start of the pandemic; 13 who died during hospital stay and 53 who were discharged alive. Data were collected consecutively from March 9th to April 27th 2020. The main outcome was the ability of the NEWS2 score and other clinical risk scores at emergency department admission to predict severe disease and in-hospital mortality in covid-19 patients. We calculated sensitivity and specificity with 95% confidence intervals (CIs) for NEWS2 scores ≥5 and ≥6, quick Sequential Organ Failure Assessment (qSOFA) score ≥2, ≥2 Systemic Inflammatory Response Syndrome (SIRS) criteria, and CRB-65 score ≥2. Areas under the curve (AUCs) for the clinical risk scores were compared using DeLong’s test.Results In total, 66 patients (mean age 67.9 years) were included. Of these, 23% developed severe disease. In-hospital mortality was 20%. Tachypnoea, hypoxemia and confusion at admission were more common in patients developing severe disease. A NEWS2 score ≥6 at admission predicted severe disease with 80.0% sensitivity and 84.3% specificity (Area Under the Curve (AUC) 0.822, 95% confidence interval (CI) 0.690-0.953). NEWS2 was superior to qSOFA score ≥2 (AUC 0.624, 95% CI 0.446-0.810, p<0.05) and other clinical risk scores for this purpose.Conclusion NEWS2 score at hospital admission predicted severe disease and in-hospital mortality, and was superior to other widely used clinical risk scores in patients with covid-19.

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“…De fleste pasientene som er innlagt på sykehus med covid-19, har redusert allmenntilstand og symptomer fra luftveiene (4)(5)(6). Et mindretall har symptomer som manglende smaks-og luktesans, magesmerter eller funksjonssvikt (7)(8)(9).…”

Section: Fortolkningunclassified

Komplikasjoner og dødelighet blant pasienter innlagt med covid-19

Ihle‐Hansen¹,

Berge²,

Ernø³

et al. 2020

Tidsskriftet

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Covid-19: Symptomer, forløp og bruk av kliniske skåringsverktøy hos de 42 første pasientene innlagt på et norsk lokalsykehus

Cited by 35 publications

References 11 publications

Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19

Comparative analysis of laboratory indexes of severe and non-severe patients infected with COVID-19

National Early Warning Score 2 (NEWS2) on admission predicts severe disease and in-hospital mortality from Covid-19 - A prospective cohort study

Komplikasjoner og dødelighet blant pasienter innlagt med covid-19

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