COVID-19 symptoms over time: comparing long-haulers to ME/CFS

Jason, Leonard A.; Islam, Mohammed; Conroy, Karl E; Cotler, Joseph; Torres, Chelsea; Johnson, Mady; Mabie, Brianna

doi:10.1080/21641846.2021.1922140

Cited by 81 publications

(74 citation statements)

References 23 publications

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“…No effective treatment exists so far. ME/CFS is often triggered by infections with various viruses, like EBV, enteroviruses, influenza virus, dengue fever and as a recent example Corona virus (SARS-CoV2) [ 17 , 18 ]. Very recent studies into post-Covid-19 syndrome (PCS) suggest that there is a broad overlap in symptomatology between both conditions [ 17 , 21 , 24 , 25 , 32 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Wirth¹,

Scheibenbogen

Paul

2021

J Transl Med

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There is accumulating evidence of endothelial dysfunction, muscle and cerebral hypoperfusion in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). In this paper we deduce the pathomechanisms resulting in central nervous pathology and the myriad of neurocognitive symptoms. We outline tentative mechanisms of impaired cerebral blood flow, increase in intracranial pressure and central adrenergic hyperactivity and how they can well explain the key symptoms of cognitive impairment, brain fog, headache, hypersensitivity, sleep disturbances and dysautonomia.

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Section: Introductionmentioning

confidence: 99%

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Wirth¹,

Scheibenbogen

Paul

2021

J Transl Med

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“…ACE2 is the receptor for SARS-CoV-2, and it plays an important role in the renin-angiotensin-aldosterone system, so maladaptation of the ACE2 might contribute to long COVID. Some studies compared long COVID with other diseases to explore its pathophysiology: one study suggested that the pathophysiology of post COVID-19 syndrome in the aspect of neurological symptoms may be similar to that of stroke [ 33 ]; another study compared long COVID patients (i.e., long hauler) with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) patients, which helped understand long COVID fatigue symptoms [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Global Trends and Research Hotspots in Long COVID: A Bibliometric Analysis

Jin

Fan

2022

IJERPH

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Long COVID is a condition distinguished by long-term sequelae that occur or persist after the convalescence period of COVID-19. During the COVID-19 pandemic, more and more people who tested positive for SARS-CoV-2 experienced long COVID, which attracted the attention of researchers. This study aims to assess the pattern of long COVID research literature, analyze the research topics, and provide insights on long COVID. In this study, we extracted 784 publications from Scopus in the field of long COVID. According to bibliometric analysis, it is found that: developed countries in Europe and America were in leading positions in terms of paper productivity and citations. The International Journal of Environmental Research and Public Health and the Journal of Clinical Medicine were leading journals in the perspective of publications count, and Nature Medicine had the highest number of citations. Author Greenhalgh T has the highest number of papers and citations. The main research topics were: pathophysiology, symptoms, treatment, and epidemiology. The causes of long COVID may be related to organ injury, inflammation, maladaptation of the angiotensin-converting enzyme 2 (ACE2) pathway, and mental factors. The symptoms are varied, including physical and psychological symptoms. Treatment options vary from person to person. Most patients developed at least one long-term symptom. Finally, we presented some possible research opportunities.

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“…Further investigations are needed to address such a possible overlap. 25,26 A third aspect is that neurocognitive impairment has not only frequently been self-reported after acute SARS-CoV-2 infection as in this study, but has already been validated in several studies as measurable deficiencies in reasoning, problem solving, spatial planning, target detection and diverse memory functions. [27][28][29][30][31][32] At least some of the studies did not suggest improvement of cognitive performance measures after COVID-19 over time, 23,28 and we also had no evidence of decreasing neurocognitive symptom prevalence within our observation period six to 12 months after acute infection.…”

Section: Discussionmentioning

confidence: 59%

Prevalence, determinants, and impact on general health and working capacity of post-acute sequelae of COVID-19 six to 12 months after infection: a population-based retrospective cohort study from southern Germany

Peter

Nieters

Kraeusslich

et al. 2022

Preprint

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Background: Post-acute sequelae of SARS-CoV-2 infection have commonly been described after COVID-19, but few population-based studies have examined symptoms six to 12 months after acute SARS-CoV-2 infection and their associations with general health recovery and working capacity. Methods: This population-based retrospective cohort study in four geographically defined regions in southern Germany included persons aged 18-65 years with PCR confirmed SARS-CoV-2 infection between October 2020 and March 2021. Symptom frequencies (six to 12 months after versus before acute infection, expressed as prevalence differences [PD] and ratios [PR]), symptom severity and clustering, risk factors and associations with general health recovery, and working capacity were analysed. Findings: Among a total of 11,710 subjects (mean age 44.1 years, 59.8% females, 3.5% previously admitted with COVID-19, mean follow-up time 8.5 months) the most prevalent symptoms with PDs >20% and PRs >5% were rapid physical exhaustion, shortness of breath, concentration difficulties, chronic fatigue, memory disturbance, and altered sense of smell. Female sex and severity of the initial infection were the main risk factors. Prevalence rates, however, appeared substantial among both men and women who had a mild course of acute infection, and PCS considerably affected also younger subjects. Fatigue (PD 37.2%) and neurocognitive impairment (PD 31.3%) as symptom clusters contributed most to reduced health recovery and working capacity, but chest symptoms, anxiety/depression, headache/dizziness and pain syndromes were also prevalent and relevant for working capacity, with some differences according to sex and age. When considering new symptoms with at least moderate impairment of daily life and ≤80% recovered general health or working capacity, the overall estimate for post-COVID syndrome was 28.5% (age- and sex-standardised rate 26.5%). Interpretation The burden of self-reported post-acute symptoms and possible sequelae, notably fatigue and neurocognitive impairment, remains considerable six to 12 months after acute infection even among young and middle-aged adults after mild acute SARS-CoV-2 infection, and impacts general health and working capacity.

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COVID-19 symptoms over time: comparing long-haulers to ME/CFS

Cited by 81 publications

References 23 publications

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

An attempt to explain the neurological symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

Global Trends and Research Hotspots in Long COVID: A Bibliometric Analysis

Prevalence, determinants, and impact on general health and working capacity of post-acute sequelae of COVID-19 six to 12 months after infection: a population-based retrospective cohort study from southern Germany

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