COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota

Bókkon, István; Kapócs, Gábor; Vucskits, András Valentin; Erdőfi-Szabó, Attila; Vagedes, Jan; Scholkmann, Felix; Szőke, Henrik

doi:10.2174/0929867328666210526100147

Cited by 6 publications

(2 citation statements)

References 203 publications

(328 reference statements)

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“…Such neuropathological alterations may also provide an explanation as, why acute neurocognitive complaints posed a “red flag” of subsequent mental health deterioration in our study cohorts. Other factors, such as Vitamin D, mitochondrial dysfunction, or gut dysbiosis, might also link COVID-19 pathobiology and mental health ( 40 ). In Random Forest modeling of mental health scoring in our study collectives, impaired physical performance following COVID-19 was found to impact particularly depression, OMH, and QoL rating.…”

Section: Discussionmentioning

confidence: 99%

Who Is at Risk of Poor Mental Health Following Coronavirus Disease-19 Outpatient Management?

et al. 2022

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BackgroundCoronavirus Disease-19 (COVID-19) convalescents are at risk of developing a de novo mental health disorder or worsening of a pre-existing one. COVID-19 outpatients have been less well characterized than their hospitalized counterparts. The objectives of our study were to identify indicators for poor mental health following COVID-19 outpatient management and to identify high-risk individuals.MethodsWe conducted a binational online survey study with adult non-hospitalized COVID-19 convalescents (Austria/AT: n = 1,157, Italy/IT: n = 893). Primary endpoints were positive screening for depression and anxiety (Patient Health Questionnaire; PHQ-4) and self-perceived overall mental health (OMH) and quality of life (QoL) rated with 4 point Likert scales. Psychosocial stress was surveyed with a modified PHQ stress module. Associations of the mental health and QoL with socio-demographic, COVID-19 course, and recovery variables were assessed by multi-parameter Random Forest and Poisson modeling. Mental health risk subsets were defined by self-organizing maps (SOMs) and hierarchical clustering algorithms. The survey analyses are publicly available (https://im2-ibk.shinyapps.io/mental_health_dashboard/).ResultsDepression and/or anxiety before infection was reported by 4.6% (IT)/6% (AT) of participants. At a median of 79 days (AT)/96 days (IT) post-COVID-19 onset, 12.4% (AT)/19.3% (IT) of subjects were screened positive for anxiety and 17.3% (AT)/23.2% (IT) for depression. Over one-fifth of the respondents rated their OMH (AT: 21.8%, IT: 24.1%) or QoL (AT: 20.3%, IT: 25.9%) as fair or poor. Psychosocial stress, physical performance loss, high numbers of acute and sub-acute COVID-19 complaints, and the presence of acute and sub-acute neurocognitive symptoms (impaired concentration, confusion, and forgetfulness) were the strongest correlates of deteriorating mental health and poor QoL. In clustering analysis, these variables defined subsets with a particularly high propensity of post-COVID-19 mental health impairment and decreased QoL. Pre-existing depression or anxiety (DA) was associated with an increased symptom burden during acute COVID-19 and recovery.ConclusionOur study revealed a bidirectional relationship between COVID-19 symptoms and mental health. We put forward specific acute symptoms of the disease as “red flags” of mental health deterioration, which should prompt general practitioners to identify non-hospitalized COVID-19 patients who may benefit from early psychological and psychiatric intervention.Clinical Trial Registration[ClinicalTrials.gov], identifier [NCT04661462].

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Section: Discussionmentioning

confidence: 99%

Who Is at Risk of Poor Mental Health Following Coronavirus Disease-19 Outpatient Management?

et al. 2022

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“…Laboratory and clinical research suggested that the well-known mitochondrial disorder responsible for different pathological states may come from an imbalance of the microbial regulation [185][186][187]. Microbiota-mitochondria disorders have been described in gastrointestinal diseases, such as in newonset Crohn's disease [188], in chronic intestinal inflammation and cancer [69], in neuropsychiatric diseases like autism [189], Parkinson's disease [190], Alzheimer's disease [179], post-traumatic stress disorder [191], depression [192], chronic fatigue syndrome [193], in metabolic diseases such as obesity and type 2 diabetes [194], in chronic Marijuana users [195], in exercise [196], in aging [197], and recently in COVID-19 [198]. Here below we discuss influences and potential benefits of some microbial metabolites and compounds on AMD.…”

Section: Microbial Metabolitesmentioning

confidence: 99%

Microbiota mitochondria disorders as hubs for early age-related macular degeneration

Fehér¹,

Élő

István

et al. 2022

GeroScience

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Age-related macular degeneration (AMD) is a progressive neurodegenerative disease affecting the central area (macula lutea) of the retina. Research on the pathogenic mechanism of AMD showed complex cellular contribution governed by such risk factors as aging, genetic predisposition, diet, and lifestyle. Recent studies suggested that microbiota is a transducer and a modifier of risk factors for neurodegenerative diseases, and mitochondria may be one of the intracellular targets of microbial signaling molecules. This review explores studies supporting a new concept on the contribution of microbiota—mitochondria disorders to AMD. We discuss metabolic, vascular, immune, and neuronal mechanism in AMD as well as key alterations of photoreceptor cells, retinal pigment epithelium (RPE), Bruch’s membrane, choriocapillaris endothelial, immune, and neuronal cells. Special attention was paid to alterations of mitochondria contact sites (MCSs), an organelle network of mitochondria, endoplasmic reticulum, lipid droplets (LDs), and peroxisomes being documented based on our own electron microscopic findings from surgically removed human eyes. Morphometry of Bruch’s membrane lipids and proteoglycans has also been performed in early AMD and aged controls. Microbial metabolites (short-chain fatty acids, polyphenols, and secondary bile acids) and microbial compounds (lipopolysaccharide, peptidoglycan, and bacterial DNA)—now called postbiotics—in addition to local effects on resident microbiota and mucous membrane, regulate systemic metabolic, vascular, immune, and neuronal mechanisms in normal conditions and in various common diseases. We also discuss their antioxidant, anti-inflammatory, and metabolic effects as well as experimental and clinical observations on regulating the main processes of photoreceptor renewal, mitophagy, and autophagy in early AMD. These findings support an emerging concept that microbiota-mitochondria disorders may be a crucial pathogenic mechanism of early AMD; and similarly, to other age-related neurodegenerative diseases, new treatment approaches should be targeted at these disorders.

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Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review

Rust¹,

Malan‐Müller²,

Heuvel³

et al. 2023

Journal of Neuroimmunology

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COVID-19: The Significance of Platelets, Mitochondria, Vitamin D, Serotonin and the Gut Microbiota

Cited by 6 publications

References 203 publications

Who Is at Risk of Poor Mental Health Following Coronavirus Disease-19 Outpatient Management?

Who Is at Risk of Poor Mental Health Following Coronavirus Disease-19 Outpatient Management?

Microbiota mitochondria disorders as hubs for early age-related macular degeneration

Platelets bridging the gap between gut dysbiosis and neuroinflammation in stress-linked disorders: A narrative review

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