2021
DOI: 10.1136/bmj.n1659
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Covid-19: Third vaccine dose boosts immune response but may not be needed, say researchers

Abstract: The interval between the first and second doses of the Oxford AstraZeneca vaccine can be extended up to 10 months and a third dose of the vaccine provides a strong boost to the immune response, according to preliminary results.

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Cited by 16 publications
(14 citation statements)
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“…Since coronavirus disease 2019 (COVID- 19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first described based on a cluster of cases in China, there have been more than 236 million confirmed cases of COVID-19, including 4.8 million deaths, and the disease has caused an ongoing global pandemic [1]. Preventive measures such as social distancing, quarantining, and wearing masks, have become an essential part of daily life, and this pandemic has affected a wide range of people's lives, including mental, physical, and social aspects [2][3][4][5].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Since coronavirus disease 2019 (COVID- 19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first described based on a cluster of cases in China, there have been more than 236 million confirmed cases of COVID-19, including 4.8 million deaths, and the disease has caused an ongoing global pandemic [1]. Preventive measures such as social distancing, quarantining, and wearing masks, have become an essential part of daily life, and this pandemic has affected a wide range of people's lives, including mental, physical, and social aspects [2][3][4][5].…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, there are still many countries facing very large waves of the disease with large unvaccinated populations. In addition, rich countries' three-dose booster regimens could impede global vaccination [19]. At present, the administration of a third COVID-19 vaccine dose is still controversial.…”
Section: Introductionmentioning
confidence: 99%
“…But there is a view that booster doses should not be prioritised over primary vaccination. In June researchers from the University of Oxford vaccine team that developed the AstraZeneca vaccine said that although a third dose of their vaccine can provide a strong boost to the immune response there was no indication that a booster was needed and emphasised that the “urgent priority” should be to ensure that people around the world got their first dose 4…”
Section: Do We Need Booster Doses?mentioning
confidence: 99%
“…1 Vaccination is the best hope for disaster management. 2 COVID-19 immunization is now widely acknowledged as a possible useful primary COVID-19 preventive strategy. Primarily, two vaccine doses are necessary for full vaccination.…”
mentioning
confidence: 99%
“…The third dosage of COVID-19 immunization as a booster dose is already in use, and the resulting immunoprotection is an issue reported in some investigations. 2 For the fourth dose, a second booster such as that given in Israel, of COVID-19 immunization, it is now a current topic for clinical study. Only a few studies have been published, and the bulk of them is limited to people with underlying medical conditions (such as organ transplantations 3 , 4 , 5 ).…”
mentioning
confidence: 99%