The problems of face-to-face meetings in Biology classrooms are the lack of flexibility and materials that cannot be accessed anytime and anywhere. Therefore, it needs to be combined with online learning or called blended learning. The purpose of this review is to describe the implementation of online and blended learning in the context of Biology education in research published from 2016 to 2022. The method used is a literature study of 23 articles by searching databases such as ERIC, Google Scholar, Scopus, and Emerald. The results of the analysis are then synthesized into several themes. Research themes regarding blended learning of Biology education in the last 5 years can be categorized into 4 themes including the effectiveness (61%), challenges of implementation (43%), strategies (61%), and perceptions (48%). Most of the article state that blended learning is effectively applied, but it also has challenges or obstacles. The strategies used in the implementation of blended learning are the use of quizzes, reflection, the use of interesting videos and pictures in the LMS, increasing student interest in online learning, and implementing feedback from the teacher to the student's work. Teachers and students have both positive and negative perceptions of various aspects of blended learning. The recommendation is that there is a need for further research on blended learning in various contexts, for example in developing countries because most of the research has been carried out in developed countries.