COVID-19: Up to 87% Critically Ill Patients Had Low Vitamin C Values.

Abstract

There are limited proven therapeutic options for the prevention and treatment of COVID-19. We underwent an observational study with the aim of measure plasma vitamin C levels in a population of adult ICU patients COVID-19 who met ARDS criteria according to the Berlin definition. This epidemiological study brings to light that up to 87% had low Vitamin C values. This observational study has the limitation it was undergone in a single center study. However, it shows an important issue. Given the potential role of vitamin C in sepsis and ARDS, there is gathering interest of whether supplementation could be beneficial in COVD-19. But, first of all, we had to know the incidence of vitamin C deficiency.

Anti-SARS-CoV-2 Strategies and the Potential Role of miRNA in the Assessment of COVID-19 Morbidity, Recurrence, and Therapy

“…Vitamin C has pleiotropic physiological functions, many of which appear to be related to COVID-19 susceptibility, including antioxidant, anti-inflammatory, anticoagulant, and immunomodulatory properties [61]. Preliminary studies show low vitamin C levels in critically ill COVID-19 patients [62]. Among the integrative therapies, vitamin C infusion may increase the synthesis of norepinephrine and vasopressin, reduce cytokine levels, and prevent neutrophils' activation [63].…”