COVID-19 vaccination and thyroiditis

Şendur, Süleyman Nahit; Oğuz, Seda Hanife; Ünlütürk, Uğur

doi:10.1016/j.beem.2023.101759

Cited by 18 publications

(23 citation statements)

References 82 publications

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“…Steroids may be needed in selected cases. Post infection SAT on the other hand may require systemic steroids in most cases [8,9].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Patterns and outcomes of late onset thyroid disturbances after COVID‐19 vaccination: A report of 75 cases

Kaur,

Reddy,

Reddy

et al. 2023

Tropical Med Int Health

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Isolated cases of subacute thyroiditis exist in the early period of COVID‐19 vaccination, largely after mRNA vaccines. Here we report late onset thyroid disturbances and persistent health issues in patients of thyroid disorders after COVID‐19 vaccination. Seventy‐five patients with post COVID‐19 vaccination thyroid disturbances were identified. Among these, 41 had flare of underlying thyroid illness, majority occurring at a median time lag of 28.4 weeks since 2nd dose. Thirty‐one cases of new onset hypothyroidism and three of new onset hyperthyroidism were reported, with a median time lag respectively of 17.2 and 22.6 weeks since 2nd dose. Most cases occurred after ChAdOx1‐nCoV‐19, which was the commonest vaccine employed in mass roll out in India. Significant improvement was observed in majority, after a median follow up of 22–26 weeks. New onset health issues persisting for ≥4 weeks were reported in 37.3% and were common in individuals with history of COVID‐19 before vaccine. New onset metabolic, musculoskeletal, and reproductive disorders were the common health complaints. Active monitoring is warranted for late onset adverse events after COVID‐19 vaccines of all types. Larger studies with involvement of unvaccinated individuals are required to understand the incidence and causality of late onset thyroid disturbances after COVID‐19 vaccines.

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“…Steroids may be needed in selected cases. Post infection SAT on the other hand may require systemic steroids in most cases [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Both flares and new onset thyroid disturbances were reported commonly in females. Females have been commonly affected also in post vaccine early onset thyroid disturbances [5,9]. Recently, in a case series of 9 patients developing Graves' disease after COVID-19 vaccination, four cases were reported in males [11].…”

Section: Discussionmentioning

confidence: 99%

Patterns and outcomes of late onset thyroid disturbances after COVID‐19 vaccination: A report of 75 cases

Kaur,

Reddy,

Reddy

et al. 2023

Tropical Med Int Health

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show abstract

“…Some articles have reported there's no changes in the incidence of hyperthyroidism before and after COVID-19 [9] . And some studies have reported that COVID-19 vaccines can cause GD [10] . But there are basically no reports study on the changes in thyroid function and thyroid autoantibody in patients with GD before and after infection in the world.…”

Section: Introductionmentioning

confidence: 99%

A retrospective clinical study in Graves disease with COVID-19 infection in China

Zhang,

Feng,

et al. 2024

Preprint

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Background Corona Virus Disease 2019 (COVID-19) is the most prevalent global pandemic in recent times. Graves disease (GD), an autoimmune thyroid disease, is a clinical syndrome caused by excessive thyroid hormones. Our study is to understand the current epidemiological situation of COVID-19 infection in GD patients, and to analyze whether COVID-19 will affect the thyroid function, thyroid autoantibody and metabolism of GD patients. Methods 109 GD patients were followed by Shanghai General Hospital Thyroid Disease Center (TDC) from November 2022 to June 2023. There were three groups defined, i.e., pre, one-month after and three months after infection with COVID-19. SPSS was used to analyze the recruited data. Results 109 GD patients are infected with COVID-19 (72.48%), uncontrolled GD patients with high FT3 had a higher COVID-19 infection rate (79.31%). As for thyroid function in 35 GD patients with antithyroid drug (ATD) maintenance stage, there were significant differences in FT3, FT4, TT3 and TT4 before and after being infected with COVID-19. What’s more, there’s a significant difference between GD patients in one month and three months after COVID-19 infection of high TSAb group (p = 0.048) but no significant difference between pre and one month. What’s more, there were significant differences in TT3, TT4 of GD patients after infected COVID-19 in non. And Phosphorus (P), 25-hydroxyvitamin D (25-OH-D3), Procollagen type 1 N-terminal propeptide (P1NP) in GD patients were be affected by COVID-19 infection. Conclusion GD patients with uncontrolled thyroid function group are susceptible to COVID-19. COVID-19 may affect the thyroid function of GD in TT3, TT4, TSAb high level group infection. COVID-19 vaccine is conducive to the stability of GD patients' condition. And COVID-19 may affect the bone metabolism in GD patients before and after COVID-19 infection. But there is no effect on glucose metabolism or lipid metabolism.

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“…Under such circumstances, although the COVID-19 mRNA vaccine was developed and administered worldwide, various adverse effects have been reported, including cardiovascular diseases such as acute coronary syndrome (ACS) and myocarditis [ 2 , 3 , 4 ], and hyperthyroidism including Graves’ disease, Graves’ orbitopathy, subacute thyroiditis, and silent thyroiditis [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…The main cause of Graves’ disease following COVID-19 vaccination is related to autoimmunity, which is explained by autoimmune/inflammatory syndrome induced by adjuvants (ASIA) and cross-reactivity between thyroid tissue including thyroid peroxidase (TPO) and the SARS-COV2 spike protein [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. The mRNA vaccine contains adjuvants such as lipid nanoparticles (LNPs) that can trigger ASIA [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Graves’ Disease after mRNA COVID-19 Vaccination, with the Presence of Autoimmune Antibodies Even One Year Later

et al. 2023

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A 45-year-old man who had received his second mRNA COVID-19 vaccination one week earlier was presented to the emergency department with chest discomfort. Therefore, we suspected post-vaccination myocarditis; however, the patient showed no signs of myocarditis. After 2 weeks, he revisited the hospital complaining of palpitations, hand tremors, and weight loss. The patient exhibited high free thyroxine (FT4) (6.42 ng/dL), low thyroid-stimulating hormone (TSH) (<0.01 μIU/mL), and high TSH receptor antibody (17.5 IU/L) levels, and was diagnosed with Graves’ disease. Thiamazole was administered, and the patient’s FT4 levels normalized after 30 days. One year later, the patient’s FT4 is stable; however, their TSH receptor antibodies have not become negative and thiamazole has continued. This is the first case report to follow the course of Graves’ disease one year after mRNA COVID-19 vaccination.

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COVID-19 vaccination and thyroiditis

Cited by 18 publications

References 82 publications

Patterns and outcomes of late onset thyroid disturbances after COVID‐19 vaccination: A report of 75 cases

Patterns and outcomes of late onset thyroid disturbances after COVID‐19 vaccination: A report of 75 cases

A retrospective clinical study in Graves disease with COVID-19 infection in China

Graves’ Disease after mRNA COVID-19 Vaccination, with the Presence of Autoimmune Antibodies Even One Year Later

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