2021
DOI: 10.1111/1756-185x.14238
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COVID‐19 vaccination can occasionally trigger autoimmune phenomena, probably via inducing age‐associated B cells

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Cited by 31 publications
(28 citation statements)
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“…Thus, it may be possible to postulate that his recent vaccine may have triggered an underlying immune dysregulation in a genetically susceptible individual to result in this first presentation of uveitis. This is supported by reports that the COVID-19 vaccines may to trigger a de-novo autoimmune phenomena (29).…”
Section: Discussionsupporting
confidence: 55%
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“…Thus, it may be possible to postulate that his recent vaccine may have triggered an underlying immune dysregulation in a genetically susceptible individual to result in this first presentation of uveitis. This is supported by reports that the COVID-19 vaccines may to trigger a de-novo autoimmune phenomena (29).…”
Section: Discussionsupporting
confidence: 55%
“…The underlying pathophysiology for vaccine-related uveitis is largely unknown, but has been postulated to be an autoimmunity triggered by the vaccines (29,35). It can be possibly due to a combination of various mechanisms including molecular mimicry, production of particular autoantibodies, antigenantibody hypersensitivity reactions, as well as the role of certain vaccine adjuvants (3,36,37).…”
Section: Discussionmentioning
confidence: 99%
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“…Another characteristic of these ABC cells lies in their role in triggering a hyper response when stimulated with Toll-like receptors 7 (TLR7) signaling, capable of generating autoreactive antibody-secreting plasmablasts. mRNA/DNA SARS-CoV-2 vaccines use TLR7/8 and TLR9 agonists as “adjuvants,” which may stimulate the subgroup of ABC, to form autoantibodies and post-vaccine autoimmune syndromes [ 30 , 31 ]. The activation of TLR7 and TLR9 can lead to the production of interferon I, an essential cytokine for the development of SLE and other ARD [ 32 ].…”
Section: Post-covid-19 Vaccine Autoimmune Syndromesmentioning
confidence: 99%
“…The World Health Organization declared Coronavirus disease 2019 (COVID-19) as a global pandemic in March 2020, and millions of people have been affected by the disease worldwide. A vaccination campaign was launched in Morocco in January 2021, resulting in a notable increase in autoimmune diseases [ 2 ]. In this report, we discuss five cases of new-onset AIBD triggered by the COVID-19 vaccine, three of which had BP while the other two had pemphigus.…”
Section: Introductionmentioning
confidence: 99%