COVID-19 vaccination hesitancy in people affected by diabetes and strategies to increase vaccine compliance: A systematic narrative review and meta-analysis

Bianchi, Francesco Paolo; Stefanizzi, Pasquale; Martinelli, Andrea; Brescia, Nazario; Tafuri, Silvio

doi:10.1016/j.vaccine.2023.01.036

Cited by 17 publications

(13 citation statements)

References 35 publications

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“…This nding concurs with ndings from similar cross-sectional studies conducted in sub-Saharan Africa that showed that concerns about vaccine safety and side effects discouraged people living with DM from accepting the COVID-19 vaccines and were responsible for their low uptake of the vaccines (16, 17). Our ndings are also supported by ndings from a meta-analysis of COVID-19 vaccination hesitancy-related studies among persons living with DM that found that the major reason for vaccine hesitancy was their belief that the vaccines are unsafe (34).…”

Section: Perceptions Of Full Covid-19 Infection and Covid-19 Vaccinationsupporting

confidence: 80%

Factors associated with full COVID-19 vaccination among persons living with diabetes mellitus in Uganda – A Cross-sectional Study

Senoga,

Guwatudde,

Isunju

et al. 2024

Preprint

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Background:Diabetes mellitus (DM) is associated with severe coronavirus disease (COVID-19) outcomes, including death. COVID-19 vaccination is the mainstay for preventing infection and severe disease in the general population, but most importantly, among high-risk populations such as persons with DM. However, while COVID-19 vaccination uptake in the general population is regularly tracked, information on vaccination behavior specific to persons with DM is scarce. This study sought to identify factors associated with the uptake of full COVID-19 vaccination among persons living with DM at Kiruddu National Referral Hospital (KRH). Methods: We used a cross-sectional study design to identify factors associated with receiving a full COVID-19 vaccination among persons with DM attending Kiruddu National Referral Hospital between March 08 and May 25, 2023. We used a systematic sampling technique to select a random sample of 340 participants for whom an interviewer-administered questionnaire was administered. We used a modified Poisson regression model to identify the factors associated with full COVID-19 vaccination and adjusted prevalence ratios with their 95% confidence intervals are presented. The data were analyzed in STATA version 14.0. Results: A total of 340 participants, 75% (255/340) of whom were female, completed the interview. The mean age of the participants was 52 years (±12 years) and the median duration of diabetes mellitus was 5 years (±7.3 years). Overall, 195/340 participants (57.35%) completed the last dose in the primary series of a COVID-19 vaccine. The likelihood of receiving full vaccination was higher when a health provider advised one to receive a vaccine [aPR=1.91 (95% CI 1.2-3.02)] when one reported having a comorbidity [aPR=1.26 (95% CI: 1.06-1.53)], and when one had a strong perceived benefit of vaccination [aPR=1.76 (95% CI: 1.23-2.53)]. However, having a strong perceived barrier to vaccination was negatively associated with the likelihood of being fully vaccinated [aPR=0.71 (95% CI: 0.6-0.84)]. Conclusion: Approximately 43% of persons living with DM in Uganda have incomplete COVID-19 vaccination. The Ugandan Ministry of Health (MoH) needs to implement a provider-initiated vaccination strategy in diabetic clinics using the healthcare providers who regularly attend to DM patients to boost their uptake of full COVID-19 vaccination.

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Section: Perceptions Of Full Covid-19 Infection and Covid-19 Vaccinationsupporting

confidence: 80%

Factors associated with full COVID-19 vaccination among persons living with diabetes mellitus in Uganda – A Cross-sectional Study

Senoga,

Guwatudde,

Isunju

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…The emerging evidence that vaccine hesitancy in patients with MFS has similar characteristics as the vaccine hesitancy previously described in the Italian and international population means that strategies for mitigating hesitancy were weak for this specific subgroup of patients even if patients with chronic conditions are typically more engaged in lifelong medical treatments [29,31]. This aspect emphasizes the fact that vaccine hesitancy in patients with chronic conditions was a concern even before COVID-19, where patients with potential high trust in biomedical research, such as those that periodically attend follow-up and take medications as per patients with MFS, do not have better features of vaccine hesitancy than the ones of the general population and might even report slightly lower acceptance rates compared with the general Italian population [20,21].…”

Section: Discussionmentioning

confidence: 93%

“…Based on analyzed data, it seems that vaccine hesitancy in patients with MFS may have similar characteristics to vaccine hesitancy in the general population [29,31], even if data on the general Italian population collected at the end of 2020 suggest a higher acceptance rate among participants enrolled in previous studies [20,21]. However, it is important to note that this study only included a small sample size of 112 individuals, and the findings may not be representative of the broader population of patients with MFS, even if considering that MFS is a rare disease, this sample is worthy of being considered insightful (its prevalence is estimated to be around 1 in 5000-10,000 individuals worldwide).…”

Section: Discussionmentioning

confidence: 98%

COVID-19 Vaccine Hesitancy in Italian Adults with Marfan Syndrome: Insights from a Secondary Analysis of a Cross-Sectional Study

et al. 2023

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Although vaccine hesitancy has been reported in many patient groups and countries, there is a lack of data on vaccine hesitancy in patients with Marfan syndrome (MFS). MFS is a rare genetic disorder that can lead to cardiovascular, ocular, and musculoskeletal issues. Because MFS patients may face an increased risk of COVID-19 complications, vaccination is crucial for this population. This brief report aims to describe vaccine hesitancy rates in MFS patients and compare the characteristics of patients who are hesitant and those who are not to gain a better understanding of this specific population. This study analyzes previously published cross-sectional data that examined mental health, sociodemographic, and clinical factors associated with PTSD, depression, anxiety, and insomnia in MFS patients during the third wave of the COVID-19 pandemic in Lombardy, Italy. Of the 112 MFS patients who participated, 26 (23.9%) reported vaccine hesitancy. Vaccine hesitancy may be associated mainly with younger age and not be related to other patient characteristics. Therefore, this report found no differences in individual-level variables, such as sex, education, comorbidities, and mental health symptoms, between those who were hesitant and those who were not. The study findings are insightful and suggest that interventions to address vaccine hesitancy in this population may need to focus on attitudes and beliefs related to vaccination rather than targeting specific sociodemographic or clinical factors.

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“…While little is known about COVID-19 vaccine intentions in persons with asthma, COVID-19 vaccine acceptance in persons with other chronic conditions is related to concerns about the vaccine’s safety, side effects, and efficacy, as well as perceived risk of severe outcomes from COVID-19 [ 36 – 39 ]. As in the general population, younger age and identifying as a minority are related to lower vaccine intention in adults with chronic conditions [ 37 , 39 ].…”

Section: Introductionmentioning

confidence: 99%

COVID-19 vaccine intentions and attitudes in Black American emerging adults with asthma

Hall,

Movva,

Dailey

et al. 2024

BMC Public Health

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Background Emerging adults (aged 18–29) are less likely to receive the COVID-19 vaccine than any other adult age group. Black Americans are less likely than non-Hispanic white Americans to be fully vaccinated against COVID-19. This study explored factors which affect vaccine intention and attitudes in Black American emerging adults with asthma. Methods Participants were recruited from an NHLBI-funded clinical trial to improve asthma control. Fifty-nine Black American emerging adults completed a Qualtrics survey that assessed asthma control, intention to vaccinate, and factors which may affect the decision to vaccinate. Twenty-five participants also completed a semi-structured interview via Zoom. Bivariate correlations and descriptive statistics, including Chi Square analyses, were run using SPSS. Interview thematic analyses were conducted via QDA Miner. Results Of the 59 Black American emerging adults with asthma who completed surveys, 32.2% responded that they were highly unlikely to receive the COVID-19 vaccine, while 50.8% responded that they were highly likely to receive it. Increased asthma control was significantly correlated with a higher likelihood to discuss the COVID-19 vaccine with their healthcare provider (ρ = 0.339, α = 0.011). Concerns about immediate (ρ= -0.261, α = 0.050) and long-term (ρ= -0.280, α = 0.035) side effects were inversely correlated with intention to vaccinate. Only 17% of the participants who were unemployed stated that they were highly likely to receive the vaccines compared to 65% of the participants who were employed; however, interview participants who were unemployed stated not needing the vaccine because they were protecting themselves by social distancing. When deciding whether to receive the vaccine, safety, efficacy, and immediate side effects were the top three factors for 91%, 54%, and 49% of the participants, respectively. Beliefs about the vaccines’ safety and efficacy, information gathering, personal factors, and societal factors emerged as important themes from the interviews. Conclusion Only half of the surveyed Black American emerging adults with asthma were highly likely to receive the COVID-19 vaccine. Safety and efficacy were important for the majority of the participants, regardless of vaccine intention. Greater asthma control, but not access to asthma-related healthcare, was correlated with intention to discuss the vaccine with their healthcare provider.

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COVID-19 vaccination hesitancy in people affected by diabetes and strategies to increase vaccine compliance: A systematic narrative review and meta-analysis

Cited by 17 publications

References 35 publications

Factors associated with full COVID-19 vaccination among persons living with diabetes mellitus in Uganda – A Cross-sectional Study

Factors associated with full COVID-19 vaccination among persons living with diabetes mellitus in Uganda – A Cross-sectional Study

COVID-19 Vaccine Hesitancy in Italian Adults with Marfan Syndrome: Insights from a Secondary Analysis of a Cross-Sectional Study

COVID-19 vaccine intentions and attitudes in Black American emerging adults with asthma

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