COVID-19 Vaccination in Kidney Transplant Candidates and Recipients

Ponticelli, Claudio; Campise, Mariarosaria

doi:10.3390/vaccines10111808

Cited by 8 publications

(4 citation statements)

References 163 publications

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“…KTRs have been a high-risk patient population throughout the COVID-19 pandemic due to their immunocompromised state. This status has led to questions about transplant patients’ abilities to fight COVID-19 infection, as well as about their abilities to mount immune responses from vaccination [ 24 ]. While growing research is increasing our knowledge about COVID-19 infection and the COVID-19 vaccine responses in immunocompromised individuals [ 25 , 26 ], less attention has been paid to the experiences of transplant patients during the pandemic as they navigate the risks of this public health crisis [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Understanding Concerns about COVID-19 and Vaccination: Perspectives from Kidney Transplant Recipients

et al. 2023

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The COVID-19 pandemic poses a significant risk for immunosuppressed groups such as transplant patients. The purpose of this study was to improve our understanding of the impact of the COVID-19 pandemic on kidney transplant recipients, including their views on COVID-19 vaccination. Semi-structured interviews were conducted from December 2021 to August 2022 with 38 kidney transplant recipients who had an appointment with their transplant care team within the previous 6 months. We used qualitative thematic analysis to characterize the perspectives of interviewees. Regardless of COVID-19 vaccination status, most interviewees reported utilizing public health measures such as masking, hand washing, and avoiding crowds to protect themselves against COVID-19. Vaccinated interviewees (n = 31) noted that they chose to receive a COVID-19 vaccine because of their increased risk due to their immunocompromised state. For unvaccinated interviewees (n = 7), reasons for not receiving a COVID-19 vaccine included concerns about the safety and efficacy of the vaccine. Both vaccinated and unvaccinated interviewees expressed concerns about the lack of adequate testing of the vaccine in transplant patients and questioned if the vaccine might have unknown side effects for transplant recipients. Regardless of the vaccination status, most interviewees noted having trust in their healthcare team. Interviewees also described interpersonal tensions that arose during the pandemic, many of which surrounded vaccination and other preventive measures that were important to participants to protect their health. Together, these data demonstrate differing concerns and experiences related to the COVID-19 pandemic for vaccinated and unvaccinated transplant recipients. These findings highlight the unique needs of transplant recipients and reveal opportunities to support this vulnerable patient population in efforts to protect their health as the COVID-19 pandemic evolves.

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Section: Discussionmentioning

confidence: 99%

Understanding Concerns about COVID-19 and Vaccination: Perspectives from Kidney Transplant Recipients

et al. 2023

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“…Although large-scale vaccination has reduced the need for, and length of, hospitalization and disease lethality in the general population and dialysis patients, such benefit was not immediately observed among kidney transplant recipients. In this group, the humoral and cellular response to vaccination was low, and lethality was sustained in more than twenty-five percent of infected patients, possibly associated with the chronic use of immunosuppressive drugs 4,8 . The situation remained unchanged regardless of virus variant and number or origin of vaccines offered, until the advent of the omicron variant, when the fatality rate among kidney transplant patients was lowered from 25% to 2% 9 .…”

Section: To Transplant or Not To Transplant During A Pandemic?mentioning

confidence: 90%

To transplant or not to transplant during a pandemic?

Medina-Pestana¹

2023

Braz. J. Nephrol.

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“…The degree of protection was particularly higher for those with "hybrid immunity" compared to those with a previous infection alone, reinforcing the importance of vaccination despite a previous infection to protect against severe disease due to the omicron variant. These observations should be interpreted cautiously; furthermore, we consider some groups to be at greater risk, such as the elderly and immunocompromised subjects including organ transplant recipients, for whom even the third booster dose may not be sufficient for protection [14][15][16]. With the analysis of the antibody response of 232 subjects to estimate how vaccination history modulated the risk of infection before and after the spread of the omicron variant, we observed differences existing in term of protection toward reinfection with the omicron variant.…”

Section: Discussionmentioning

confidence: 99%

Antibody Response against SARS-CoV-2 after mRNA Vaccine in a Cohort of Hospital Healthy Workers Followed for 17 Months

Tripodi,

Dominici,

Sacco

et al. 2024

Vaccines

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The assessment of antibody response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of critical importance to verify the protective efficacy of available vaccines. Hospital healthcare workers play an essential role in the care and treatment of patients and were particularly at risk of contracting the SARS-CoV-2 infection during the pandemic. The vaccination protocol introduced in our hospital protected the workers and contributed to the containment of the infection’ s spread and transmission, although a reduction in vaccine efficacy against symptomatic and breakthrough infections in vaccinated individuals was observed over time. Here, we present the results of a longitudinal and prospective analysis of the anti-SARS-CoV-2 antibodies at multiple time points over a 17-month period to determine how circulating antibody levels change over time following natural infection and vaccination for SARS-CoV-2 before (T0–T4) and after the spread of the omicron variant (T5–T6), analyzing the antibody response of 232 healthy workers at the Pio XI hospital in Desio. A General Estimating Equation model indicated a significant association of the antibody response with time intervals and hospital area, independent of age and sex. Specifically, a similar pattern of antibody response was observed between the surgery and administrative departments, and a different pattern with higher peaks of average antibody response was observed in the emergency and medical departments. Furthermore, using a logistic model, we found no differences in contracting SARS-CoV-2 after the third dose based on the hospital department. Finally, analysis of antibody distribution following the spread of the omicron variant, subdividing the cohort of positive individuals into centiles, highlighted a cut-off of 550 BAU/mL and showed that subjects with antibodies below this are more susceptible to infection than those with a concentration above the established cut-off value.

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COVID-19 Vaccination in Kidney Transplant Candidates and Recipients

Cited by 8 publications

References 163 publications

Understanding Concerns about COVID-19 and Vaccination: Perspectives from Kidney Transplant Recipients

Understanding Concerns about COVID-19 and Vaccination: Perspectives from Kidney Transplant Recipients

To transplant or not to transplant during a pandemic?

Antibody Response against SARS-CoV-2 after mRNA Vaccine in a Cohort of Hospital Healthy Workers Followed for 17 Months

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