COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study

Pařenica, Jiří; Benešová, Klára; Radvan, Martin; Sanca, Ondrej; Hlásenský, Jiří; Lokaj, Petr; Ondrúš, Tomáš; Helánová, Kateřina; Kala, Petr; Dušek, Ladislav; Jarkovský, Jiří

doi:10.3389/fcvm.2022.998842

Cited by 8 publications

(5 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, for high-risk patients, such as the elderly and those with cardiovascular diseases, medication and lifestyle interventions should be used to prevent and mitigate HF. Moreover, the ndings underscore the importance of COVID-19 vaccination in reducing cardiovascular complications in HF patients, as evidenced by studies from New York City and the Czech Republic showing lower hospitalization and mortality rates among vaccinated individuals [44,45]. The application of COVID-19 vaccines is becoming increasingly widespread [46].…”

Section: Implications For Clinical Practicementioning

confidence: 99%

Effects of COVID-19 on Heart Failure and Its Risk Factors: A Bidirectional Mendelian Randomization Study

Liu,

Huang,

Sun

et al. 2024

Preprint

View full text Add to dashboard Cite

Introduction Previous studies suggest a potential link between COVID-19 and cardiovascular diseases, particularly heart failure (HF), but causal relationships remain unclear. This study uses bidirectional Mendelian randomization (MR) to investigate these associations.Materials and methods We selected genome-wide association study (GWAS) datasets detailing COVID-19 phenotypes as exposures, while traits associated with HF and its risk factors constituted the outcomes. Our primary estimation method involved utilizing the inverse-variance weighted technique for it could provide a precise estimation by giving more weight to studies with less variance. Alongside, we deployed the weighted median, MR-Egger, MR-PRESSO global test, and Cochran’s Q statistic to address biases, detect and correct for pleiotropy, and assess heterogeneity. Furthermore, we conducted bidirectional MR analysis to ascertain the directional causality.Results Based on the bidirectional MR analysis, our findings indicate a higher likelihood of developing into HF among hospitalized COVID-19 patients, as well as an increased propensity for HF development in individuals with all COVID-19 patients. Furthermore, the presence of HF increases the prevalence of COVID-19, escalates the severity of COVID-19, and raises the hospitalization rate in those affected by COVID-19. COVID-19 does not directly escalate the incidence of the risk factors of HF, but type 2 diabetes mellitus (T2DM) could increases the hospitalization and severity rates of COVID-19 patients. Meanwhile, chronic kidney disease (CKD) contributes to increased hospitalization rates among COVID-19 patients.Conclusion This study provides evidence of a bidirectional causal link among COVID-19 and HF and its risk factors. These findings suggest clinical implications for early detection and management of HF in COVID-19 patients and highlight the need for targeted healthcare resources.

show abstract

Section: Implications For Clinical Practicementioning

confidence: 99%

Effects of COVID-19 on Heart Failure and Its Risk Factors: A Bidirectional Mendelian Randomization Study

Liu,

Huang,

Sun

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Furthermore, Remdesivir, which halved viral production, led to a lower risk of hospitalization, a shorter hospital stay, or death, with an overall reduction of infection-related detrimental cardiovascular events. Dexamethasone demonstrated to reduce mortality in critically ill COVID-19 patients, and recent data highlighted the clear reduction of in-hospital intensive care hospitalization for HF patients with a history of vaccination during the SARS-CoV-2 Omicron wave, which was more pronounced in those with a booster dose [ 18 ]. An interesting analysis from the MedStar Health system compared the clinical characteristics and outcomes in patients with myocardial injury across the COVID-19 waves.…”

Section: Difference In Cardiovascular Comorbidities Cardiovascular Co...mentioning

confidence: 99%

Acute COVID-19 Management in Heart Failure Patients: A Specific Setting Requiring Detailed Inpatient and Outpatient Hospital Care

Palazzuoli

Beltrami

McCullough³

2023

Biomedicines

View full text Add to dashboard Cite

The relationship existing between heart failure (HF) and COVID-19 remains questioned and poorly elucidated. Many reports suggest that HF events are reduced during pandemics, although other studies have demonstrated higher mortality and sudden death in patients affected by HF. Several vascular, thrombotic, and respiratory features may deteriorate stable HF patients; therefore, the infection may directly cause direct myocardial damage, leading to cardiac function deterioration. Another concern is related to the possibility that antiviral, anti-inflammatory, and corticosteroid agents commonly employed during acute COVID-19 infection may have potentially deleterious effects on the cardiovascular (CV) system. For these reasons, HF patients deserve specific management with a tailored approach in order to avoid arrhythmic complications and fluid retention events. In this review, we describe the complex interplay between COVID-19 and HF, the evolving trend of infection with related CV events, and the specific management strategy to adopt in this setting.

show abstract

“…In a population-based cohort study in the Czech Republic in 2022, 9728 patients with HF who contracted COVID-19 (SARS-CoV-2) were evaluated. They found that the risk of intensive care hospitalization was 7.6% in unvaccinated patients, 4.8% in vaccinated patients and only 2.9% in patients who received a booster dose 54 .…”

Section: Role Of Covid-19 Vaccinesmentioning

confidence: 99%

Immunizing hearts: exploring the vaccination frontier in heart failure management

Shivamadhu,

Jalal,

Sandhu

et al. 2023

Annals of Medicine &Amp; Surgery

View full text Add to dashboard Cite

Heart failure (HF) is a widespread clinical condition that affects numerous individuals globally and is a leading cause of hospitalization, particularly in the elderly population. Despite efforts to manage heart failure using various pharmacological and non-pharmacological interventions, mortality and hospitalization rates remain alarmingly high. Preventive vaccination has emerged as a key measure endorsed by cardiology societies for reducing the morbidity and mortality associated with HF. This study undertakes an extensive review of existing literature to explore the role of vaccination in managing HF, focusing specifically on the immunological pathways involved and potential benefits offered by immunization in this context. This article highlights the role of various vaccines, including influenza, pneumococcal, and COVID-19 vaccines, in reducing HF-related hospitalization, mortality, and overall disease burden. Additionally, this article will delve into specific vaccines that have shown promise in heart failure management, such as influenza, pneumococcal, and COVID-19 vaccines, along with the rationale for their use, clinical trials, meta-analyses, and real-world data supporting their effectiveness in patients with heart failure. This article also considers potential challenges and obstacles to widespread vaccination in individuals with heart failure, which include vaccine hesitancy, accessibility, and adverse events related to vaccines.

show abstract

COVID-19 vaccine booster significantly decreases the risk of intensive care unit hospitalization in heart failure patients during the Omicron variant wave: A population-based study

Cited by 8 publications

References 34 publications

Effects of COVID-19 on Heart Failure and Its Risk Factors: A Bidirectional Mendelian Randomization Study

Effects of COVID-19 on Heart Failure and Its Risk Factors: A Bidirectional Mendelian Randomization Study

Acute COVID-19 Management in Heart Failure Patients: A Specific Setting Requiring Detailed Inpatient and Outpatient Hospital Care

Immunizing hearts: exploring the vaccination frontier in heart failure management

Contact Info

Product

Resources

About