COVID-19 vaccine boosters: What do we know so far?

Kherabi, Yousra; Fiolet, Thibault; Rozencwajg, Sacha; Salaün, Jean‐Philippe; Peiffer-Smadja, Nathan

doi:10.1016/j.accpm.2021.100959

Cited by 18 publications

(22 citation statements)

References 8 publications

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“…The most effective regimen for COVID‐19 vaccination is still unknown as data continue to evolve following the waning of immunity over time and the emergence of new variants. 9 Israel's study on the real‐world protection of the boosters of vaccination showed that the third dose of BNT162b2 mRNA vaccination significantly reduced the COVID‐19 infection rate, severe illness rate, and mortality rate of vaccinators. 10 COVID‐19 vaccine boosting might ultimately be required in the general population due to diminishing immunity or the emergence of new variants.…”

Section: Discussionmentioning

confidence: 99%

Humoral immune response of BBIBP COVID‐19 vaccination before and after the booster immunization

Cheng

Huang

Zheng

et al. 2022

Allergy

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Background The inactivated Sinopharm/BBIBP COVID‐19 vaccine has been widely used in the world and has joined the COVAX vaccine supply program for developing countries. It is also well adapted for usage in low‐ and middle‐income nations due to their low storage requirements. Objective This study aims to report on the kinetics, durability, and neutralizing ability of the induced immunity of the BBIBP vaccine, and the intensified antibody response elicited by the booster. Methods A total of 353 healthy adult participants, aged 20–74 years, were recruited in this multicenter study. A standard dose of the BBIBP vaccine was administered (Month 0), followed by a second standard dose (Month 1), and a booster dose (after Month 7). Vaccine‐induced virus‐specific antibody levels (SARS‐CoV‐2‐IgA/IgM/IgG), conventional virus neutralization test (cVNT), pseudovirus neutralization test (pVNT), and surrogate virus neutralization test (sVNT) were monitored over multiple time points. Results Neutralizing titers induced by the two doses of inactivated vaccine for COVID‐19 peaked at Month 2 and declined to 33.89% at Month 6. Following the booster dose, elevated levels of antibodies were induced for IgA, IgG, and neutralizing antibodies, with neutralizing titer reaching 13.2 times that of before the booster. Conclusion By monitoring the antibody titer levels postvaccination, this study has shown that serum antibody levels will decrease over time, but a notable spike in antibody levels postbooster highlights the anamnestic immune response. This signifies that the protection capability has increased following the injection of booster immunization.

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Section: Discussionmentioning

confidence: 99%

Humoral immune response of BBIBP COVID‐19 vaccination before and after the booster immunization

Cheng

Huang

Zheng

et al. 2022

Allergy

View full text Add to dashboard Cite

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“…A decrease in the vaccine-induced response of neutralizing antibodies to the emerging variants has also been reported. 20 Campbell et al has found that the effective reproduction number estimate of the Delta variant increased by 55%, 60% and 34% compared to the Alpha, Beta, and Gamma variants, respectively. 22 For the BNT162b2 vaccine, the effectiveness of two-dose vaccination was 88.0% among those infected with the delta variant, compared with the rate of 93.7% among people with the alpha variant.…”

Section: Discussionmentioning

confidence: 99%

“… 18 , 19 It was constructed based on the assumption that people tend to adopt disease prevention behaviors (e.g., vaccination) if they perceive that they are susceptible to the disease, the disease is severe, the prevention behavior is beneficial, barriers are minimal, or if they have received recommendations from family members or health care workers. 20 Thirteen HBM questions were developed and were divided into five dimensions (perceived susceptibility, perceived severity, perceived benefit, perceived barriers, and cues to action). Questions were asked about the perception of the participants and their families concerning their susceptible to COVID-19 infection (perceived susceptibility), whether COVID-19 would damage the health of theirs and their family members’ (perceived severity), whether booster shots were unsafe, ineffective, or might trigger COVID-19 infection (perceived barriers), whether booster shots were protective against COVID-19 or have benefits for health (perceived benefits), and whether they would receive vaccination upon the recommendation from physicians, family members or community workers (cues to action).…”

Section: Methodsmentioning

confidence: 99%

The association between social media use and hesitancy toward COVID-19 vaccine booster shots in China: A web-based cross-sectional survey

Wang

Qin

et al. 2022

Human Vaccines & Immunotherapeutics

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COVID-19 vaccine booster shots are necessary to provide durable immunity and stronger protection against the emerging SARS-CoV-2 variants. As a major platform for access to information, social media plays an important role in disseminating health information. This study aimed to evaluate hesitancy toward COVID-19 vaccine booster shots in China, assess its association with social media use, and provide information to manage social media. We conducted a cross-sectional study across all 31 provinces in mainland China from November 12, 2021, to November 17, 2021. In total, 3,119 of 3,242 participants completed the questionnaire (response rate = 96.2%). COVID-19 vaccine booster shot hesitancy rate in China was 6.5% (95% CI: 5.6–7.3). Unemployment (adjusted odds ratio [aOR] 2.428, 95% CI: 1.590–3.670), low monthly income (aOR 2.854,95% CI: 1.561–5.281), low scores of knowledge (aOR 0.917, 95% CI: 0.869–0.968) and low level of cues to action (aOR 0.773, 95% CI: 0.689–0.869) were associated with vaccine hesitancy. Compared with public social media, lower vaccine hesitancy was associated with high perceived importance of social media (aOR 0.252, 95% CI: 0.146–0.445) and official social media use (aOR 0.671, 95% CI: 0.467–0.954), while higher vaccine hesitancy was associated with traditional media use (aOR 3.718, 95% CI: 1.282–10.273). More efforts are needed to regulate the content of social media and filtering out misinformation. The role of official social media in disseminating health information should be enhanced.

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“…COVID-19 vaccines have proven to be highly effective at limiting morbidity and mortality associated with SARS-CoV-2 infection [1]. However, the ongoing emergence of new SARS-CoV-2 variants of concern, and waning immunity among already vaccinated individuals, have highlighted the need for additional vaccine doses to boost population immunity [2][3][4]. In settings where primary series coverage exceeds 50%, booster dose programs may be a more effective strategy for limiting population-wide negative effects of COVID-19 disease than improving primary series uptake among the unvaccinated [5].…”

Section: Introductionmentioning

confidence: 99%

Transition to endemic: acceptance of additional COVID-19 vaccine doses among Canadian adults in a national cross-sectional survey

et al. 2022

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Background Additional doses of COVID-19 vaccine have been proposed as solutions to waning immunity and decreased effectiveness of primary doses against infection with new SARS-CoV-2 variants. However, the effectiveness of additional vaccine doses relies on widespread population acceptance. We aimed to assess the acceptance of additional COVID-19 vaccine doses (third and annual doses) among Canadian adults and determine associated factors. Methods We conducted a national, cross-sectional online survey among Canadian adults from October 14 to November 12, 2021. Weighted multinomial logistic regression analyses were used to identify sociodemographic and health-related factors associated with third and annual dose acceptance and indecision, compared to refusal. We also assessed influences on vaccine decision-making, and preferences for future vaccine delivery. Results Of 6010 respondents, 70% reported they would accept a third dose, while 15.2% were undecided. For annual doses, 64% reported acceptance, while 17.5% were undecided. Factors associated with third dose acceptance and indecision were similar to those associated with annual dose acceptance and indecision. Previous COVID-19 vaccine receipt, no history of COVID-19 disease, intention to receive an influenza vaccine, and increasing age were strongly associated with both acceptance and indecision. Chronic illness was associated with higher odds of acceptance, while self-reported disability was associated with higher odds of being undecided. Higher education attainment and higher income were associated with higher odds of accepting additional doses. Minority first language was associated with being undecided about additional doses, while visible minority identity was associated with being undecided about a third dose and refusing an annual dose. All respondents reported government recommendations were an important influence on their decision-making and identified pharmacy-based delivery and drop-in appointments as desirable. Co-administration of COVID-19 and influenza vaccines was viewed positively by 75.5% of the dose 3 acceptance group, 12.3% of the undecided group, and 8.4% of the refusal group. Conclusions To increase acceptance, targeted interventions among visible minority and minority language populations, and those with a disability, are required. Offering vaccination at pharmacies and through drop-in appointments are important to facilitate uptake, while offering COVID-19/influenza vaccine co-administration may have little benefit among those undecided about additional doses.

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COVID-19 vaccine boosters: What do we know so far?

Cited by 18 publications

References 8 publications

Humoral immune response of BBIBP COVID‐19 vaccination before and after the booster immunization

Humoral immune response of BBIBP COVID‐19 vaccination before and after the booster immunization

The association between social media use and hesitancy toward COVID-19 vaccine booster shots in China: A web-based cross-sectional survey

Transition to endemic: acceptance of additional COVID-19 vaccine doses among Canadian adults in a national cross-sectional survey

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