COVID-19 vaccine hesitancy among parents in Low- and Middle-Income Countries: A meta-analysis

Kheir-Mataria, Wafa Abu El; Saleh, Basma; El-Fawal, Hassan A. N.; Chun, Sungsoo

doi:10.3389/fpubh.2023.1078009

Cited by 16 publications

(5 citation statements)

References 32 publications

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“…Despite recent systematic reviews in low-and middle-income countries (LMICs) [18][19][20], this review aims to synthesize and map the current literature specifically in African countries, which are not well represented in the above reviews due to the persistent challenges in the rollout of vaccines and subsequent vaccination of the population on the African continent. We furthermore intend to extend the focus on COVID-19 vaccine uptake and VH to include more detailed information on the individual, interpersonal, and structural barriers and facilitators to COVID-19 vaccination.…”

Section: Introductionmentioning

confidence: 99%

Factors Influencing the Intention and Uptake of COVID-19 Vaccines on the African Continent: A Scoping Review

2023

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The COVID-19 pandemic is a severe concern worldwide, particularly in Africa. Vaccines are crucial in the fight against the COVID-19 pandemic. This scoping review examined existing literature from 2020 to 2022 on individual, interpersonal, and structural barriers and facilitators to COVID-19 vaccination within Africa to facilitate more informed health promotion interventions to improve vaccine uptake. This review was conducted using Arksey and O’Malley’s five-stage methodological framework. A comprehensive search was undertaken from 2021 to 2022 using six electronic databases: EBSCOhost, PubMed, Web of Science, ProQuest, WorldCat Discovery, and Google Scholar. Data was collected, charted into themes, and summarized using a standard data extraction sheet in Microsoft Excel. A total of forty (n = 40) published academic articles were reviewed, with many conducted in Nigeria (n = 10), followed by Ethiopia (n = 5) and Ghana (n = 4) and the rest elsewhere in Africa. Thematic narratives were used to report data into six themes: attitudes and perceptions about COVID-19 vaccines, intention to uptake COVID-19 vaccines; factors and barriers associated with COVID-19 vaccine uptake; socio-demographic determinants affecting the intention and uptake; and information sources for COVID-19 vaccines. The intention for uptake ranged from 25% to 80.9%, resulting in a suboptimal uptake intention rate (54.2%) on the African continent. Factors that promoted vaccine acceptance included confidence in the COVID-19 vaccines and the desire to protect people. Age, education, and gender were the most common factors significantly associated with vaccine acceptance. Most studies revealed that considerable barriers to vaccine uptake exist in Africa. Concerns about potential side effects, vaccine ineffectiveness, a perceived lack of information, and inaccessibility were among the individual, interpersonal, and structural barriers to COVID-19 vaccine uptake. The unwillingness to receive the COVID-19 vaccine was strongly correlated with being female. Mass and social media were the main sources of information regarding COVID-19 vaccines. To encourage vaccine uptake, governments should pay attention to refuting misinformation through integrated community-based approaches, such as creating messages that convey more than just information.

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Section: Introductionmentioning

confidence: 99%

Factors Influencing the Intention and Uptake of COVID-19 Vaccines on the African Continent: A Scoping Review

2023

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“…However, only 17.4% of the population in LMICs had received their first dose, showcasing the limited access and availability of the COVID-19 vaccine [ 39 ]. According to research, 49% of LMIC parents agreed to vaccinate their children and believed that COVID-19 vaccines would be effective in containing the pandemic [ 40 ]. The worldwide parental acceptance rate for COVID-19 vaccines is 58% [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Ethical Challenges Involved in COVID-19 Vaccine Mandates for Children: A Systematic Review

Alahmad

2023

Vaccines

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The new COVID-19 pandemic has affected day-to-day life, creating various ethical dilemmas. COVID-19 vaccination is seen as an effective way to halt the pandemic. Ethical challenges can arise when the vaccines are mandated for all ages, but more so when mandated for children. This systematic review discusses the pros and cons of the COVID-19 vaccine mandate for children. The primary objective of this study is to summarize exclusively the various ethical conflicts, impacts, and requirements that arise as a result of the COVID-19 vaccine mandate laws on children. The secondary objective is to analyze the reasons for parents refusing to allow their children to be given the COVID-19 vaccine sand the effective strategies to increase vaccine uptake among children. The study involved a systematic review, identification of relevant literature and reviews following the PRISMA-ScR recommendations. The keywords ‘COVID-19 vaccine mandates on children’ were used to mine the literature from PubMed and WHO COVID-19 Research Database. Limitations placed on the original searches were: English language, humans, ethics, and children. Out of 529 studies, only 13 satisfied the selection criteria. The sample included studies with a wide, diverse range of methods, settings, research, authors, and journals. COVID-19 vaccine mandates on children need to be scrutinized. Implementing the COVID-19 vaccination drive in a scientific way is acceptable. As children are the fastest-growing population and have the highest life expectancy, it is important to take into account that the vaccines do not disturb their growth and development.

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“…Those parents with positive vaccination intentions were predominantly motivated by a desire to return to normality through reducing disease transmission by vaccinating their children thereby protecting their children and society in general. A recent meta-analysis of quantitative studies assessing COVID-19 vaccine hesitancy among parents in low- and middle-income countries [ 91 ], found parents not wanting to vaccinate their children had concerns about vaccine efficacy, safety and side effects. Of the 49% of parents willing to vaccinate their children, most believed that vaccination was crucial to ending the pandemic.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of the BNT162b2 vaccine in preventing morbidity and mortality associated with COVID-19 in children aged 5 to 11 years: A systematic review and meta-analysis

Ebrahim,

Blose,

Gloeck

et al. 2023

PLOS Glob Public Health

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A rapid systematic review, based on Cochrane rapid review methodology was conducted to assess the effectiveness of two 10μg doses of BNT162b2 vaccine in preventing morbidity and mortality associated with COVID-19 in children aged 5 to 11 years. We searched the Cochrane Library COVID-19 study register, the COVID-NMA living review database and the McMaster University Living Evidence Synthesis for pre-appraised trials and observational studies up to 7 December 2022. Records were screened independently in duplicate. Where appraisal was not available, these were done in duplicate. Meta-analysis was conducted using RevMan 5.3 presenting risk ratios/odds ratios/inverse vaccine efficacy with 95% confidence intervals (CI). GRADE for assessing the overall certainty of the evidence was done in Gradepro. We screened 403 records and assessed 52 full-text articles for eligibility. One randomised controlled trial (RCT) and 24 observational studies were included. The RCT reported that BNT162b2 was likely safe and 91% efficacious, RR 0.09 (95% CI 0.03 to 0.32) against incident COVID-19 infection (moderate certainty evidence). In absolute terms, this is 19 fewer cases per 1,000 vaccines delivered (ranging from 15 to 21 fewer cases). Observational studies reported vaccine effectiveness (VE) against incident COVID-19 infection of 65% (OR 0.35, 95% CI 0.26 to 0.47) and 76% against hospitalisation (OR 0.24, 95% CI 0.13 to 0.42) (moderate certainty evidence). The absolute effect is 167 fewer cases per 1,000 vaccines given (ranging from 130 fewer to 196 fewer cases) and 4 fewer hospitalisations per 10,000 children (from 3 fewer to 5 fewer hospitalisations). Adverse events following vaccination with BNT162b2 were mild or moderate and transient. The evidence demonstrated a reduction in incident COVID-19 cases and small absolute reduction in hospitalisation if a two-dose BNT162b2 vaccine regimen is offered to children aged 5 to 11 years, compared to placebo. PROSPERO registration: CRD42021286710.

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COVID-19 vaccine hesitancy among parents in Low- and Middle-Income Countries: A meta-analysis

Cited by 16 publications

References 32 publications

Factors Influencing the Intention and Uptake of COVID-19 Vaccines on the African Continent: A Scoping Review

Factors Influencing the Intention and Uptake of COVID-19 Vaccines on the African Continent: A Scoping Review

Ethical Challenges Involved in COVID-19 Vaccine Mandates for Children: A Systematic Review

Effectiveness of the BNT162b2 vaccine in preventing morbidity and mortality associated with COVID-19 in children aged 5 to 11 years: A systematic review and meta-analysis

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