COVID-19 Vaccine Reactogenicity and Vaccine Attitudes Among Children and Parents/Guardians After Multisystem Inflammatory Syndrome in Children or COVID-19 Hospitalization: September 2021—May 2022

Abstract

Background: Multisystem inflammatory syndrome in children (MIS-C) is a multiorgan hyperinflammatory condition following SARS-CoV-2 infection. Data on COVID-19 vaccine adverse events and vaccine attitudes in children with prior MIS-C are limited. We described characteristics associated with COVID-19 vaccination, vaccine adverse events and vaccine attitudes in children with a history of MIS-C or COVID-19 and their parents/guardians. Methods: We enrolled children previously hospitalized for MIS-C or COVID-19 from 3 academic institutions. We abstracted charts and interviewed children and parents/guardians regarding vaccine adverse events and acceptability. Results: Of 163 vaccine-eligible children enrolled with a history of MIS-C and 70 with history of COVID-19, 51 (31%) and 34 (49%), respectively, received mRNA COVID-19 vaccine a median of 10 (Interquartile Range 6–13) months after hospital discharge. Among 20 children with MIS-C and parents/guardians who provided interviews, local injection site reaction of brief duration (mean 1.8 days) was most commonly reported; no children required medical care within 2 weeks postvaccination. Vaccine survey results of interviewed, vaccinated children and their parents/guardians: of 20 children with MIS-C and 15 children with COVID-19, 17 (85%) and 13 (87%), respectively, listed doctors in the top 3 most trusted sources for vaccine information; 13 (65%) and 9 (60%) discussed vaccination with their doctor. Conclusions: COVID-19 vaccination was well tolerated in children with prior MIS-C or COVID-19 participating in our investigation. Parents/guardians regarded their children’s doctors as a trusted source of information for COVID-19 vaccines, and most vaccinated children’s parents/guardians had discussed COVID-19 vaccination for their child with their doctor.

COVID-19 Vaccine Acceptance Among Parents of Children With Multisystem Inflammatory Syndrome in Children

“…Indeed, other studies reported that pediatricians were among the most trusted source of information for COVID-19 vaccination. 19,21 In conclusion, our study found that the acceptance of COVID-19 vaccines among parents of children with MIS-C was comparable to that of the general Swiss population, and it did not increase after the MIS-C episode in their child. A minority of MIS-C children received the COVID-19 vaccine after their MIS-C episode, primarily among the older age group.…”

“…Indeed, other studies reported that pediatricians were among the most trusted source of information for COVID-19 vaccination. 19 , 21 …”

COVID-19 in the Asia Pacific: impact on climate change, allergic diseases and One Health

“…To improve the accuracy of reporting of vaccine anaphylaxis, the Brighton Collaboration Classification for anaphylaxis was updated in 2022 to increase the use of objective signs and reduce the dependence on subjective symptoms of anaphylaxis for vaccination centers and emergency providers to diagnose anaphylaxis [ 24 ]. Vaccine injury financial assistance programs may paradoxically have triggered unintended anxieties in some patients and parents, reducing regional vaccination rates in certain countries, and increasing the risk of severe COVID-19 among the vulnerable elderly and immunocompromised and need for healthcare resources [ 25 – 27 ]. Alternative vaccine platforms including inactivated virus vaccines (Sinovac-CoronaVac) and protein subunit vaccines (Novavax/Nuvaxovid) were subsequently made available for adults, with mRNA vaccination programs progressively rolled out to include children from as young as 6 months old (Pfizer-BionTech/Comirnaty and Moderna/Spikevax).…”