COVID-19 vaccine trials and sex-disaggregated data

Hussain, Musaddique; Fatima, Mehwish; Iqbal, Shahid; Asif, Muhammad; Ullah, Malik Saad; Khan, Kashif-ur-Rehman; Mukhtar, Imran; Khan, Imran; Parveen, Sajida; Fayyaz, Tehreem; Shabbir, Najia; Kanwal, Aisha; Shaukat, Saira; Fatima, Mobeen; Ikram, N; Majeed, Abdul; Parveen, Farzana; Tariq, Muhammad; Barkat, Qasim; Wu, Ximei

doi:10.1080/14760584.2022.2015331

Cited by 9 publications

(7 citation statements)

References 23 publications

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“…For example Uwamino et al reported similar observations in a cohort of 673 recipients of BNT162b2 [13], while Xu et al reported stronger and more durable antibody responses in females and younger recipients of an inactivated vaccine [14]. There are a number of potential underlying biological mechanisms that could lead to a sex difference, and stronger antibody responses in women have been reported for other vaccines [15].…”

Section: Discussionmentioning

confidence: 92%

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Strength and durability of antibody responses to BNT162b2 and CoronaVac

Cowling

Wong

Shiu

et al. 2022

Preprint

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Section: Discussionmentioning

confidence: 92%

“…There are a number of potential underlying biological mechanisms that could lead to a sex difference, and stronger antibody responses in women have been reported for other vaccines [15].…”

Section: Discussionmentioning

confidence: 99%

Strength and durability of antibody responses to BNT162b2 and CoronaVac

Cowling

Wong

Shiu

et al. 2022

Preprint

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“…Historically, males and females have shown different reactions to vaccines of many kinds [22,23]. In few reports, female had higher antibody response [24,25].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2022

JCCM

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Background: Patients with end stage renal disease (ESRD) on maintenance hemodialysis (ESRD on MHD) are at high risk of contracting SARS-CoV-2 and developing severe COVID-19 infection. An altered immunologic response to COVID-19 vaccines was reported in this population. This study aimed to assess the level of anti-Spike antibody 2 weeks after 4 doses of COVID-19 vaccine in patients on MHD. Methods:A cross-sectional descriptive study was conducted in August 2022 among patients with ESRD on MHD who received COVID-19 vaccine 4 doses; last dose was 2 weeks ago. Data were collected by using standardized forms and analysis was done.Results: A total of 61 patients with ESRD on maintenance hemodialysis (ESRD on MHD) were included; all patients had raised anti-Spike antibody level; the median anti-Spike antibody level was 3912 U/mL. The mean age was 51.15 ± 12.85 years. The older age group (over 50 years) had higher anti-Spike antibody level than younger age group (less than 50 years), 4175.5 U/mL and 3024.5 U/ mL respectively. Mean BMI (dry weight) was 19.93 ± 2.83 kg/m2. Anti-Spike antibody level was highest in normal BMI group 4117 U/mL; 3180 U/mL in overweight group; and, the lowest 1680 U/mL in underweight group. This study included male 26 (42.6%) and female 35 (57.4%); no difference in anti-Spike antibody level between male (3928 U/mL) and female (3912 U/mL). Nearly 70% of them had history of COVID-19 infection and they had higher anti-Spike antibody level (4400 U/mL) than those without infection (2355 U/mL). Those with diabetes mellitus had significantly higher anti-Spike antibody level (11,935 U/mL) than those without diabetes mellitus (3,155 U/mL). Anti-Spike antibody level in smokers (3149 U/mL) was lower than that of non-smoker (4059 U/ mL). Those who got vaccinated in the morning had higher antibody level (4232 U/mL) than who got in the afternoon (3003 U/mL). Antibody response decreased with falling hemoglobin; mild anemia (4232 U/mL); moderate anemia (3103.5 U/mL); and severe anemia (1680 U/mL). Presence of diabetes mellitus was the only significant predictor for anti-Spike antibody level on univariable analysis.

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“…A third possibility is to provide tables of results disaggregated by key demographic variables. For example, in medical and social science research contexts, the importance of disaggregating data by sex has been emphasized (for just one example, see Hussain et al, 2022). Each of these options accomplishes the broader goal of greater sample characterization, while avoiding some of the potential risks in data re-use.…”

Section: Re-use Of Demographic Data: Key Considerationsmentioning

confidence: 99%

A Unified Approach to Demographic Data Collection for Research with Young Children Across Diverse Cultures

Singh¹,

Barokova²,

Baumgartner³

et al. 2022

Preprint

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Culture is a key determinant of children’s development both in its own right and for understanding the generalizability of developmental phenomena. Studying the role of culture in development requires information about participants’ demographic backgrounds. However, both reporting and treatment of demographic data are limited and inconsistent in child development research. A barrier to reporting demographic data in a consistent fashion is that no standardized tool currently exists to collect these data. Variation in cultural expectations, family structures, and life circumstances across communities make the creation of a unifying instrument challenging. Here, we present a framework to standardize demographic reporting for early child development (birth to 3 years of age), focusing on six sociodemographic construct categories: biological information, gestational status, health status, community of descent, caregiving environment, and socioeconomic status. For each, we discuss potential measurement items and provide guidance for their use and adaptation to different contexts. These items are stored in a repository of context-adapted questionnaires that provide a consistent approach to obtaining and reporting demographic information so that these data can be archived and shared in a more standardized format. The public significance of this work is to facilitate diversification of participants within developmental psychology by providing a framework for capturing demographic diversity.

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COVID-19 vaccine trials and sex-disaggregated data

Cited by 9 publications

References 23 publications

Strength and durability of antibody responses to BNT162b2 and CoronaVac

Strength and durability of antibody responses to BNT162b2 and CoronaVac

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A Unified Approach to Demographic Data Collection for Research with Young Children Across Diverse Cultures

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