COVID-related dysphonia and persistent long-COVID voice sequelae: A systematic review and meta-analysis

Lin, Chung‐Wei; Wang, Yuhan; Li, Yu-En; Chiang, Tihao; Chiu, Li‐Wen; Lin, Hsin‐Ching; Chang, Chun‐Tuan

doi:10.1016/j.amjoto.2023.103950

Cited by 10 publications

(2 citation statements)

References 46 publications

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“…The findings of the present study were particularly important regarding the potential increase of LPR symptoms in COVID-19 [ 21 ], which may be attributed to the increase of both anxiety and stress in the population. In that way, a recent meta-analysis suggested an increase in dysphonia during and post-COVID-19 infection [ 22 ], which should be attributed to LPR. The occurrence of chronic vagus nerve dysfunction in long COVID-19 patients [ 23 ] is an additional important issue to explore in future studies.…”

Section: Discussionmentioning

confidence: 99%

Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine

Rodriguez,

Steffens,

Calvo-Henriquez

et al. 2023

Medicina

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Background and Objective: To examine the effects of the lockdown on diet adherence and stress levels in patients with laryngopharyngeal reflux (LPR). Materials and Methods: Patients with a positive LPR diagnosis at the hypopharyngeal-esophageal impedance-pH monitoring were treated from a pre- to lockdown period with a 3-month high-protein, low-fat, alkaline, plant-based diet, with behavioral changes, and an association of pantoprazole (20 MG/d) and alginate (Gaviscon 3/d). The following patient-reported outcomes questionnaire and findings instrument were used: Reflux Symptom Score-12 (RSS-12) and Reflux Sign Assessment (RSA). At the posttreatment time, patients were invited to evaluate the impact of lockdown on diet adherence and stress management with a predefined grid of foods and beverages and the perceived stress scale (PSS), respectively. Results: Thirty-two patients completed the evaluations. RSS-12 and RSA significantly improved from baseline to 3-month posttreatment. Most patients experienced mild-to-severe stress levels at the end of the lockdown. The level of stress substantially increased in 11 patients (34%) due to the lockdown, while it did not change in 11 patients (44%). In 11 cases (34%), patients reported that the adherence to the anti-reflux diet was better than initially presumed thanks to the lockdown period, while 44% (N = 14) reported that the lockdown did not impact the adherence to a diet. PSS and RSS-12 were significantly correlated at the end of the pandemic (rs = 0.681; p < 0.001). The increase in stress level was positively associated with the lack of adherence to diet (rs = 0.367; p = 0.039). Conclusions: During the lockdown, the diet habits of LPR patients were improved in one-third and unchanged in 44% of cases. The stress level was increased in one-third of patients, which was associated with an increase in symptom scores.

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Section: Discussionmentioning

confidence: 99%

Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine

Rodriguez,

Steffens,

Calvo-Henriquez

et al. 2023

Medicina

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“…Die Autoren untersuchten insgesamt 702 Patienten mit mildem bis moderatem COVID-Verlauf (d. h. ohne Intensivbehandlung), davon waren 26,8 % dysphonisch. Ein Jahr später veröffentlichten Lin et al 5 eine Metaanalyse aus 21 Publikationen. Von den dort erfassten 13 948 Patienten entwickelten 20,1 % eine Long-COVID-Dysphonie.…”

Section: Diskussionunclassified

Aus der Gutachtenpraxis: Stimmstörungen nach COVID ohne Intubation oder Tracheotomie – Fakt oder Fiktion? *

Angerstein

2024

Laryngorhinootologie

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Increasing Prevalence of Voice Disorders in the USA: Updates in the COVID Era

Naunheim,

DeVore,

Huston

et al. 2024

The Laryngoscope

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ObjectiveTo estimate the current prevalence of voice disorders among adults in the United States; to determine the association of individual factors with voice disorders.MethodsThe 2022 National Health Interview Survey (NHIS) was analyzed to identify adults reporting voice problems in the past 12 months. Demographics were assessed, as well as the duration, severity, and resolution of the voice problem. The relationship between voice problems, gender, lost workdays, and long COVID was investigated. A comparison to the 2012 NHIS was made to determine changes in voice disorder prevalence.Results29.9 million Americans (95%CI[28.3–31.5]) annually report a voice problem, representing 12.2% of the population (95%CI[11.7–12.8%]). Overall, 26.8% and 13.2% reported the severity of their voice problem as moderate or severe, respectively. Only 5.1% (95%CI[4.3–6.0%]) of respondents sought treatment. Most voice problems were resolved within 1 week (53.0%,95%CI[50.9–55.1%]). Females were more likely than males to report a voice problem (14.4% vs. 10.0%,95%CI[13.7–15.1] and [9.3–10.7], respectively). The 17.6 million Americans with long COVID symptoms were more likely to have voice complaints than those without (21.1% vs. 11.6%,95%CI[18.9–23.5%] and [11.1–12.1%], respectively). Lost workdays were not significantly higher for those with voice disorders compared to those without (17.1 vs. 12.9 days,95%CI[12.0–22.1] and [11.0–14.8], respectively).ConclusionsVoice problems affect approximately 1 in 8 adults in the U.S. annually, demonstrating an alarming increased prevalence since 2012 using the same survey methodology. Relatively few individuals seek care for their voice problem, despite significant self‐reported impact. Further study is required regarding the impact of COVID and changes in voice use patterns on voice disorders.Level of Evidence3 Laryngoscope, 2024

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COVID-related dysphonia and persistent long-COVID voice sequelae: A systematic review and meta-analysis

Cited by 10 publications

References 46 publications

Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine

Laryngopharyngeal Reflux Patient Changes during the COVID-19 Quarantine

Aus der Gutachtenpraxis: Stimmstörungen nach COVID ohne Intubation oder Tracheotomie – Fakt oder Fiktion? *

Increasing Prevalence of Voice Disorders in the USA: Updates in the COVID Era

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