COVID19 Vaccination Considerations for Pregnant Women: A Systematic Review

Abstract

Background: Following the coronavirus disease 2019 (COVID-19) pandemic, pregnant women are at a higher risk of developing severe COVID-19 disease. This study investigated whether pregnant women should get vaccinated against COVID-19 or not. Pregnant women in comparison with non-pregnant women. Materials and Methods: This study was a systematic review that searched the PubMed, Embase, and Scopus databases using the keywords “COVID-19” OR “SARS-CoV-2” OR “Coronavirus Disease” OR “2019-nCoV” AND “pregnancy “OR “pregnant” AND “vaccine” OR “vaccination” from January 2020 to April 2022. Results: Of the 37 selected studies, 15 (40.50%) declared positive views, 9 (24.30%) had inconclusive views, and 13 (35.20%) opposed vaccination due to a lack of adequate information. Conclusions: Despite the discrepancies among the studies, one-third of the studies suggested that pregnant women be enrolled in clinical trials to investigate the outcomes of the COVID-19 vaccination on maternal and fetal outcomes. However, the majority of the studies recommended maternal immunization against COVID-19.