Cow's Milk Induced Malabsorption as a Precursor of Gluten Intolerance

A Modern Clinical Approach to Food Hypersensitivity

“…This lesion disappears when the offending food is removed and reappears when the food is returned to the diet (36)(37)(38)(40)(41)(42), and it is fully described in these and other reports. Essentially, the villi of the intestinal mucosa become flattened and the lamina propria is infiltrated by lymphoid cells shown to be producing specific antibodies of IgA, IgG, IgM and sometimes IgE classes of immunoglobulins.…”

“…The condition is transient so that by 2 to 3 years of age the offending foods can be consumed without reactions. If the guilty food is not identified and eliminated from the diet, diarrhea may become intractable and fatal (39) or intestinal malabsorption and malnutrition may develop (41).…”

Immunochemical study of the malabsorption syndrome with cow's milk intolerance

“…A syndrome consisting of failure to thrive, vomiting, diarrhoea, malabsorption, and damage to the jejunal mucosa has been recognized in young infants, many of whom have never received gluten (Davidson, Bumstein, Kugler, and Bauer, 1965;Fallstrom, Winberg, and Andersen, 1965;Kuitunen, 1966;Visakorpi and Immonen, 1967;Liu, Tsao, Moore, and Giday, 1967;Silver and Douglas, 1968). It has been demonstrated earlier that most of these patients are intolerant to cow's milk and especially to its proteins (Davidson et al, 1965;Visakorpi and Immonen, 1967;Liu et al, 1968).…”

The management of chronic or recurrent diarrhoea in childhood

“…The diagnosis of such patients is particularly difficult, and usually requires that the patient resume a normal diet for some months to see if demonstrable histological or biochemical abnormalities develop. Some response to a gluten-free diet is not specific for coeliac disease (Fallstrom, Winberg & Andersen, 1965;Hindle & Creamer, 1965;Parfitt, 1966) and therapeutic trials of a gluten-free diet have no place as a diagnostic method unless circumstances make appropriate laboratory investigation impossible.…”