COX-2 in Cardiovascular Disease

Bishop‐Bailey, David; Mitchell, Jane A.; Warner, Timothy D.

doi:10.1161/01.atv.0000219672.68024.bc

Cited by 54 publications

(33 citation statements)

References 23 publications

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“…There is a body of evidence in favor of the latter (19) . However, recent evidence indicates that it may be a mixture of the two enzymes (26,27) , a fact that would be in agreement with the early observation that the concentration of 6-oxo PGF1α, the stable end product of the metabolism of prostacyclin, is elevated in patients with atherosclerosis (28) .…”

Section: The Vascular Endotheliumsupporting

confidence: 85%

El endotelio vascular

Moncada

2014

An Fac med

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ResumenLa investigación sobre el endotelio vascular en los últimos 40 años ha provisto ideas para entender la enfermedad vascular. Este nuevo conocimiento ha encontrado su camino en la medicina clínica. En esta revisión nos ocupamos de ciertas áreas de la investigación en las que se ha obtenido avances significativos en la prevención y el tratamiento cardiovascular, así como algunas interrogantes que aún permanecen sin respuesta. Palabras clave: Endotelio vascular, enfermedad vascular, investigación cardiovascular. Abstract Over the last 40 years, research on the vascular endothelium has provided important clues for the understanding of vascular disease. This new knowledge is finding its way into clinical medicine. In this review we deal with some areas where significant advances in the prevention and treatment of cardiovascular research has been achieved and with some of the remaining questions.

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Section: The Vascular Endotheliumsupporting

confidence: 85%

El endotelio vascular

Moncada

2014

An Fac med

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“…13 Endothelial COX-1 from normal vessels may be more readily inhibited by NSAIDs than platelet COX-1, preventing endothelial PGI 2 formation but not platelet-derived TxA 2 . 14 It may be that the apparent selectivity of a given COX inhibitor is determined by a target cell's peroxide content and arachidonate availability, rather than selectivity for a particular isoform.…”

Section: The Prostaglandin Biosynthesis Quandarymentioning

confidence: 99%

Maintaining Equilibrium by Selective Targeting of Cyclooxygenase Pathways

et al. 2008

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“…Two main factors may infl uence relative levels of a particular transcript in heterogeneous cell samples; one is an effective up-or downregulation of its expression in one or more cell types present in the sample, and the other is the alteration of the proportion of cell types expressing that transcript. It is well-known that COX-1 is ubiquitously expressed ( 6,7 ). Therefore, the increase of COX-1 in AAA was probably due to the enhanced proportion of cells with high MVECs were seeded onto Matrigel in 96-well plates and exposed to 10 nmol/l of PGE 2 or Cay10598 (an EP-4 agonist).…”

Section: Ep-4-activation-mediated In Vitro Angiogenesismentioning

confidence: 99%

Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm

Camacho

Dilmé

Solà-Villà

et al. 2013

Journal of Lipid Research

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Abdominal aortic aneurysm (AAA) is a late-age onset disorder that affects a high percentage of the population in industrialized countries, and rupture of AAA is associated with high mortality rates ( 1 ). The etiology of AAA is complex with a relevant contribution of genetic factors ( 2 ). Although much effort has been made to clarify the mechanism of AAA development, currently the only effective approach to prevent aneurysm rupture is surgical repair by conventional or endovascular techniques.Evidence has been established for a relationship between atherosclerosis and AAA, both disorders being characterized by an underlying chronic infl ammation . However, there are marked differences between atherosclerotic lesions and AAA. Whereas atherosclerotic plaque is characterized by leukocyte infi ltration at the lumen site and hyperproliferation of vascular smooth muscle cells (VSMCs) causing neointimal hyperplasia, AAA is characterized by leukocyte infi ltration into adventitia and depletion of VSMCs in the media. Other relevant features of AAA are the wall tension strength breakdown caused by proteolytic enzymes progressively destructing elastic fi bers ( 3 ) and hypervascularization of aortic tissue. It has been proposed that this vascularization might contribute to the development and rupture of aneurysms ( 4, 5 ). Abstract We investigated the prostaglandin (PG)E

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COX-2 in Cardiovascular Disease

Cited by 54 publications

References 23 publications

El endotelio vascular

El endotelio vascular

Maintaining Equilibrium by Selective Targeting of Cyclooxygenase Pathways

Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm

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