COX-2 Inhibitors Prolong Trauma-Induced Elevations of Iris Hyaluronan

Koralewska-Makár, Anna; Johnsson, Cecilia; Bruun, Anitha; Stenevi, Ulf; Ehinger, Berndt

doi:10.1089/108076803322279444

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Effects Of Selective Cox-2 Inhibitors In Ophthalmology1

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Cited by 4 publications

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“…59 Rofecoxib and SC-236, a selective COX-2 inhibitor, prolonged trauma-induced elevations of hyaluronan in the iris of rabbits. 75 Celecoxib inhibits retinal VEGF expression and vascular leakage in diabetic rats. 76 In addition, in diabetic rat retinas, PGE 2 expression was significantly inhibited by celecoxib, indicating the potential value of using celecoxib to treat diabetic retinopathy.…”

Section: Effects Of Selective Cox-2 Inhibitors In Ophthalmologymentioning

confidence: 99%

The Pathophysiologic Role of Cyclooxygenases in the Eye

Radi

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2008

Journal of Ocular Pharmacology and Therapeutics

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Cyclooxygenase isoenzymes (COX-1 and -2) catalyze the conversion of arachidonic acid to prostaglandins (PGs) and play a significant role in the health and disease of the eye. Experimental animal models of ocular diseases have been used to assess the effects of the selective COX inhibitors (COXIBs), and nonselective, nonsteroidal anti-inflammatory drugs (ns-NSAIDs) are currently employed in the management of various ophthalmic conditions. This paper provides a review of the comparative expression of COX-1 and COX-2 in the eye under normal and pathologic conditions, including the pathophysiologic role of PGs, and the effects of ns-NSAIDs and selective COX-2 inhibitors in the treatment of ophthalmic conditions.

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Section: Effects Of Selective Cox-2 Inhibitors In Ophthalmologymentioning

confidence: 99%