Cox-maze IV cryoablation and postoperative heart failure in mitral valve surgery patients

Boano, Gabriella; Aneq, Meriam Åström; Kemppi, Jennie; Vánky, Farkas

doi:10.1080/14017431.2016.1196827

Cited by 6 publications

(4 citation statements)

References 29 publications

(37 reference statements)

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“…The possible contribution of cryoablation to postoperative heart failure has previously been discussed [38]. The use of inotropes at weaning from extracorporeal circulation was significantly higher in the cryoablation patients compared with the non-ablated patients, but the addition of ablation to mitral valve surgery and the type of energy source did not seem to influence the early postoperative levels of NT-proBNP.…”

Section: Postoperative Heart Failurementioning

confidence: 96%

Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial

et al. 2020

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Background: Surgical cryothermia and radiofrequency (RF) ablations for atrial fibrillation (AF) seem to result in similar sinus rhythm restoration, but the biochemical consequences of the two methods are unclear. We aimed to compare the biochemical responses to the two ablative methods in concomitant mitral valve surgery (MVS). Methods: Sixty mitral valve surgery patients with AF were prospectively included. Forty-one patients planned for ablation were randomized to cryothermia (n = 20) or radiofrequency (n = 21) ablation and 19 served as controls. Markers for myocardial injury, inflammation, cell stress, apoptosis, and heart failure were analyzed pre-and postoperatively at different time points. Results: Troponin T and creatine kinase isoenzyme MB (CK-MB) peak levels were significantly higher in the cryothermia group compared with the RF group (12,805 [6140-15,700] vs. 2790 [1880-4180] ng/L; P = 0.002 and 271 [217-357] vs. 79 [66-93] μg/L; P < 0.001, respectively). Both groups had significantly higher levels than the noablation group. There were no group differences in C-reactive protein (CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), but there were correlations between pre-and postoperative levels of both CRP (r s = 0.41, P = 0.001) and NT-proBNP (r s = 0.48, P < 0.001). Protease-activated receptor 1 (PAR-1) and heat shock protein 27 (HSP27) were significantly increased in the cryoablation group. Conclusions: Cryoablation results in a larger myocardial injury and possibly more elevated apoptotic activity and cell stress compared with the RF technique. The type of ablation device did not have any significant influence on the postoperative inflammatory response nor on the early postoperative levels of NT-proBNP.

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Section: Postoperative Heart Failurementioning

confidence: 96%

Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial

et al. 2020

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“…The possible contribution of cryoablation to postoperative heart failure has previously been discussed [35]. The use of inotropes at weaning from extracorporeal circulation was significantly higher in the cryoablation patients compared with the non-ablated patients, but the addition of ablation to mitral valve surgery and the type of energy source did not seem to influence the early postoperative levels of NT-proBNP.…”

Section: Postoperative Heart Failurementioning

confidence: 96%

Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial.

Boano

Aneq

Spyrou

et al. 2020

Preprint

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Background Surgical cryothermia and radiofrequency (RF) ablations for atrial fibrillation (AF) seem to result in similar sinus rhythm restoration, but the biochemical consequences of the two methods are unclear. We aimed to compare the biochemical responses to the two ablative methods in concomitant mitral valve surgery (MVS).Methods Sixty mitral valve surgery patients with AF were prospectively included. Forty-one patients planned for ablation were randomized to cryothermia (n = 20) or radiofrequency (n = 21) ablation and 19 served as controls. Markers for myocardial injury, inflammation, cell stress, apoptosis, and heart failure were analyzed pre- and postoperatively at different time points.Results Troponin T and creatine kinase isoenzyme MB (CK-MB) peak levels were significantly higher in the cryothermia group compared with the RF group (12805 [6140–15700] vs. 2790 [1880–4180] ng/L; P = 0.002 and 271 [217–357] vs. 79 [66–93] µg/L; P < 0.001, respectively). Both groups had significantly higher levels than the no-ablation group. There were no group differences in C-reactive protein (CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), but there were correlations between pre- and postoperative levels of both CRP (rs=0.41, P = 0.001) and NT-proBNP (rs=0.48, P < 0.001). Protease-activated receptor 1 (PAR-1) and heat shock protein 27 (HSP27) were significantly increased in the cryoablation group.Conclusions Cryoablation results in a larger myocardial injury and possibly more elevated apoptotic activity and cell stress compared with the RF technique. The type of ablation device did not have any significant influence on the postoperative inflammatory response nor on the early postoperative levels of NT-proBNP.

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“…The possible contribution of cryoablation to postoperative heart failure has previously been discussed [39]. The use of inotropes at weaning from extracorporeal circulation was signi cantly higher in the cryoablation patients compared with the non-ablated patients, but the addition of ablation to mitral valve surgery and the type of energy source did not seem to in uence the early postoperative levels of NT-proBNP.…”

Section: Postoperative Heart Failurementioning

confidence: 96%

Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial.

Boano

Aneq

Spyrou

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Abstract Background: Surgical cryothermia and radiofrequency (RF) ablations for atrial fibrillation (AF) seem to result in similar sinus rhythm restoration, but the biochemical consequences of the two methods are unclear. We aimed to compare the biochemical responses to the two ablative methods in concomitant mitral valve surgery (MVS). Methods: Sixty mitral valve surgery patients with AF were prospectively included. Forty-one patients planned for ablation were randomized to cryothermia (n=20) or radiofrequency (n=21) ablation and 19 served as controls. Markers for myocardial injury, inflammation, cell stress, apoptosis, and heart failure were analyzed pre- and postoperatively at different time points. Results: Troponin T and creatine kinase isoenzyme MB (CK-MB) peak levels were significantly higher in the cryothermia group compared with the RF group (12805 [6140–15700] vs. 2790 [1880–4180] ng/L; P=0.002 and 271 [217–357] vs. 79 [66–93] µg/L; P<0.001, respectively). Both groups had significantly higher levels than the no-ablation group. There were no group differences in C-reactive protein (CRP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP), but there were correlations between pre- and postoperative levels of both CRP (rs=0.41, P=0.001) and NT-proBNP (rs=0.48, P<0.001). Protease-activated receptor 1 (PAR-1) and heat shock protein 27 (HSP27) were significantly increased in the cryoablation group. Conclusions: Cryoablation results in a larger myocardial injury and possibly more elevated apoptotic activity and cell stress compared with the RF technique. The type of ablation device did not have any significant influence on the postoperative inflammatory response nor on the early postoperative levels of NT-proBNP.Trial registration: DOI:10.1186/ISRCTN14454361. Registered 16 November 2014 – Retrospectively registered, http://www.isrctn.com/ISRCTN14454361

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Cox-maze IV cryoablation and postoperative heart failure in mitral valve surgery patients

Cited by 6 publications

References 29 publications

Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial

Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial

Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial.

Biochemical response to cryothermal and radiofrequency exposure of the human myocardium at surgical ablation of atrial fibrillation: a randomized controlled trial.

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