Coxiella burnetii Infection of Aneurysms or Vascular Grafts: Report of Seven Cases and Review

Fournier, Pierre‐Edouard; Casalta, Jean Paul; Piquet, Philippe; Tournigand, P; Branchereau, A; Raoult, Didier

doi:10.1086/516255

Cited by 92 publications

(88 citation statements)

References 6 publications

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“…• Hepatitis could be asymptomatic and is characterized by a raise in the transaminase levels alone or associated with a prolonged fever of unknown origin or by an infectious hepatitis rarely with jaundice [43] but with hepatomegaly.…”

Section: In Humansmentioning

confidence: 99%

Is Q Fever an emerging or re-emerging zoonosis?

2005

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-Q fever is a zoonotic disease considered as emerging or re-emerging in many countries. It is caused by Coxiella burnetii, a bacterium developing spore-like forms that are highly resistant to the environment. The most common animal reservoirs are livestock and the main source of infection is by inhalation of contaminated aerosols. Although the culture process for Coxiella is laborious, advances on the knowledge of the life cycle of the bacterium have been made. New tools have been developed to (i) improve the diagnosis of Q fever in humans and animals, and especially animal shedders, (ii) perform epidemiological studies, and (iii) prevent the disease through the use of vaccines. This review summarizes the state of the knowledge on the bacteriology and clinical manifestations of Q fever as well as its diagnosis, epidemiology, treatment and prevention in order to understand what factors are responsible for its emergence or re-emergence. Coxiella burnetii / epidemiology / bacteriology / diagnostic / control

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Section: In Humansmentioning

confidence: 99%

Is Q Fever an emerging or re-emerging zoonosis?

2005

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“…Acute Q fever is usually mild (20,22), but patients with cardiovascular abnormalities are at risk of developing chronic infection (10,26). In patients with chronic Q fever, endocarditis is the most common feature, but vascular infections are also observed (7,13,23). Q fever has been estimated to represent 3 to 5% of all cases of endocarditis (6).…”

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confidence: 99%

Molecular Detection of Coxiella burnetii in the Sera of Patients with Q Fever Endocarditis or Vascular Infection

2004

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In the absence of a specific diagnosis based on serology, chronic Q fever is inevitably fatal. However, diagnosis is often delayed because the test is not widely available. To shorten the diagnostic delay, we adapted a nested-PCR assay with serum as a template and the LightCycler as a thermal cycler, termed LCN-PCR. We retrospectively and prospectively applied this method to samples from 48 patients diagnosed with Q fever endocarditis or vascular infection and to samples from 100 controls with endocarditis caused by other microorganisms. We also prospectively applied this technique to samples from 30 patients treated for a Q fever endocarditis and to samples from 13 patients with a convalescent acute Q fever with ambiguous immunoglobulin G (IgG) phase I titer. LCN-PCR had a specificity of 100%. It was positive only in samples from patients with evolutive Q fever, as none of the samples from patients with a treated chronic Q fever or with a convalescent acute Q fever presented positive results. When performed prospectively on recently stored sera, the sensitivity of LCN-PCR is 64% (7 of 11 samples; P ‫؍‬ 0.004), but the efficiency of LCN-PCR was dramatically altered by the storage of specimens at ؊20°C. High IgG phase I titers decreased the sensitivity of LCN-PCR. A significant difference was observed among LCN-PCR results for sera with IgG phase I titers of >1:25,600 compared to sera with IgG phase I titers of <1:25,600 (0 of 15 samples versus 13 of 33 samples; P ‫؍‬ 0.004). In patient samples with titers below 1:25,600 tested prospectively, sensitivity was 100% (7 of 7). The LCN-PCR assay may be helpful in establishing an early diagnosis of chronic Q fever.

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“…Q fever occurs worldwide [1], but the incidence is probably underestimated [2] because of the insidiousness of the infection and lack of clinician awareness. It is easily detectable with a simple, low-cost, and reliable serologic examination with immunofluorescence.…”

Section: Introductionmentioning

confidence: 99%

Coxiella burnetii infection of an aortic graft: surgical view and a word of caution

Georghiou

Hirsch

Vidne

et al. 2004

Interactive Cardiovascular and Thoracic Surgery

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A 30-year-old-man presented with an aortic graft infection. Polymerase chain reaction study identified the infectious organism as Coxiella burnetii, a strictly intracellular pathogen that causes Q fever in humans. The patient was successfully treated by removal of the infected graft, implantation of homograft aortic tube, and specific antibiotic therapy. He is doing well after 6 months, with no evidence of recurrent homograft infection on transthoracic echocardiography. C. burnetii vascular graft infections may be underdiagnosed because of lack of recognition. We suggest that serologic tests for C. burnetii be routinely performed in the presence of unexplained febrile illness or pain in patients with a history of underlying vascular disease.

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Coxiella burnetii Infection of Aneurysms or Vascular Grafts: Report of Seven Cases and Review

Cited by 92 publications

References 6 publications

Is Q Fever an emerging or re-emerging zoonosis?

Is Q Fever an emerging or re-emerging zoonosis?

Molecular Detection of Coxiella burnetii in the Sera of Patients with Q Fever Endocarditis or Vascular Infection

Coxiella burnetii infection of an aortic graft: surgical view and a word of caution

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