COXSACKIE B, MUMPS, RUBELLA, AND CYTOMEGALOVIRUS SPECIFIC IgM RESPONSES IN PATIENTS WITH JUVENILE-ONSET INSULIN-DEPENDENT DIABETES MELLITUS IN BRITAIN, AUSTRIA, AND AUSTRALIA

Banatvala, J. E.; Schernthaner, G.; Schober, Edith; Silva, L.M. De; Bryant, Jennifer; Borkenstein, M; Brown, D.; Menser, Margaret A.; Silink, Martin

doi:10.1016/s0140-6736(85)91843-4

Cited by 202 publications

(109 citation statements)

References 15 publications

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“…The present finding of a similarly low prevalence of specific CB-IgM in Type 1 diabetic patients as in referent subjects during the autumn period as well as the late spring period probably reflects the seasonal variation of these viral infections in the paediatric population at large. Similar figures have been reported in population studies by other investigators [5,6]. During the periods studied, these data do not indicate that CB viruses had any relationship to the development of Type 1 diabetes, or, more specifically, the data show that the CB-IgM frequency in the diabetic group was not 50% different from that seen in the referent group.…”

Section: Discussionsupporting

confidence: 89%

The Swedish childhood diabetes study III: IgM against coxsackie B viruses in newly diagnosed Type 1 (insulin-dependent) diabetic children ? no evidence of increased antibody frequency

et al. 1989

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Summary. Sera from essentially all Swedish children aged 0-14 years with Type 1 (insulin-dependent) diabetes mellitus with onset during an autumn period (October-December 1985) and a late spring period (May-June 1986) were selected. In all, 98 patients were analysed for IgM antibodies against coxsackie B virus serotypes 1 through 5 by a Ix-antibody capture radio immunoassay technique. Sera from 94 referent children matched for age, sex and residential area, collected during the same period, were also analysed. During the autumn period, 10 out of 67 (15%) diabetic children were IgM positive while 14 out of 75 (19%) of the healthy referent children demonstrated positivity. During the late spring period only one out of 31 (3%) children with diabetes and two out of 19 (10%) referent children were IgM positive. In the diabetic patients, five were coxsackie B2 positive while coxsackie B1, 3, 4 and 5 were represented by one to three patients each. Eight referent children were coxsackie B4 positive, six were B3 positive and two B2 positive, while no referent children were positive against coxsackie B1 and 5. During these two periods in late 1985 and early 1986 these data demonstrate no evidence of increased antibody frequency against coxsackie B virus 1 through 5 at the onset of childhood diabetes in Sweden.

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Section: Discussionsupporting

confidence: 89%

The Swedish childhood diabetes study III: IgM against coxsackie B viruses in newly diagnosed Type 1 (insulin-dependent) diabetic children ? no evidence of increased antibody frequency

et al. 1989

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“…Assuming that viruses may play a role in the direct initiation of autoimmune insulitis, the association of recent virus infections with the appearance of ICA in the pre-diabetic period rather than at the onset of disease should be noted. Precise matching of patients and control subjects by area of residence is often difficult to achieve, particularly when the group studied consists of hospital in-patients [5]. The requirements for appropriate control subjects are ideally 837 met in our study where age-and sex-matched class-mates of the probands were used.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies no association between these virus infections and the onset of Type 1 diabetes was found [5][6][7]. Although mumps infection may result in transient ICA, islet cell surface antibodies and insulin-autoantibody responses [t9 -20], and may occasionally cause Type i diabetes [21], there is little evidence that these viruses are a significant cause of Type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Although the difference in prevalence between ICA positive and negative individuals was not statistically significant, a study of larger numbers would be required to exclude such an association. A number of serological studies have found a higher prevalence of coxsackie B virus-specific IgM responses in patients at Type 1 diabetes onset compared with control subjects [5,8,9,22] while others have not [6][7]. In one study, the prevalence of IgM among Type i diabetic patients showed considerable geographic and temporal variation, ranging from 0-76 % [9].…”

Section: Discussionmentioning

confidence: 99%

“…This evidence is based on studies in animal models [1], anecdotal case reports in which viruses have been isolated from patients at the time of Type 1 diabetes onset [2][3][4] and seroepidemiological studies to determine the prevalence of virus-specific IgM responses in patients with recently diagnosed Type 1 diabetes [5][6][7][8][9], indicating that virus infection is present in a proportion of patients around the time of diabetes onset. In view of the long incubation period before clinical diabetes becomes apparent in man, it is pertinent to consider whether virus infection may be involved in the initiation of the disease process, rather than simply the precipitation of disease in patients with already compromised Beta-cell function.…”

mentioning

confidence: 99%

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No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7?19 years

et al. 1991

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Summary. Viral antibodies were tested in a cohort of 44 isletcell antibody-positive individuals age 7-19 years, and 44 of their islet cell antibody-negative age and sex-matched classmates selected from a population study of 4208 pupils who had been screened for islet cell antibodies. Anti-coxsackie B1-5 IgM responses were detected in 14 of 44 (32 %) of the islet cell antibody-positive subjects and in 7 of 44 (16 % ) control subjects. This difference did not reach the level of statistical significance. None of the islet cell antibody-positive subjects had specific IgM antibodies to mumps, rubella, or cytomegalovirus. There was also no increase in the prevalence or the mean titres of anti-mumps-IgG or IgA and anti-cytomegalovirus-IgG in islet cell antibody-positive subjects compared to control subjects. These results do not suggest any association between islet cell antibodies, and possibly insulitis, with recent mumps, rubella or cytomegalovirus infection. Further studies are required to clarify the relationship between islet cell antibodies and coxsackie B virus infections.

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Detection of Coxsackie B Virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus

et al. 1997

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Enteroviruses may be linked to insulin-dependent diabetes mellitus (IDDM). The prevalence of enteroviral (EV) infection at onset of adult IDDM was investigated by detection of specific EV sequences in peripheral blood using a reverse transcription and a seminested polymerase chain reaction (seminested RT-PCR). EDTA-treated whole blood samples taken from 12 newly diagnosed IDDM patients with ketosis or ketoacidosis were examined. The comparison groups were 12 adult patients suffering from metabolic decompensation in the course of IDDM, 12 adult patients with decompensated non-IDDM, and 15 healthy adults without any presumed EV infection or metabolic disease. EV genome was detected in five of 12 (42%) newly diagnosed IDDM patients and in one of 12 (8%) patients in the course of IDDM. By contrast, none of the 12 non-IDDM patients and none of the 15 healthy adults had EV sequences in whole blood. Subsequent sequencing of the EV PCR products from the six positive patients showed a significant homology with Coxsackie B3 or B4 viruses, and some common patterns were observed among the sequences. The present study demonstrates that Coxsackie B virus RNA sequences can be detected in peripheral blood from patients at the onset or in the course of IDDM and provides evidence for a role for enteroviruses in adult type I diabetes.

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COXSACKIE B, MUMPS, RUBELLA, AND CYTOMEGALOVIRUS SPECIFIC IgM RESPONSES IN PATIENTS WITH JUVENILE-ONSET INSULIN-DEPENDENT DIABETES MELLITUS IN BRITAIN, AUSTRIA, AND AUSTRALIA

Cited by 202 publications

References 15 publications

The Swedish childhood diabetes study III: IgM against coxsackie B viruses in newly diagnosed Type 1 (insulin-dependent) diabetic children ? no evidence of increased antibody frequency

The Swedish childhood diabetes study III: IgM against coxsackie B viruses in newly diagnosed Type 1 (insulin-dependent) diabetic children ? no evidence of increased antibody frequency

No association between islet cell antibodies and coxsackie B, mumps, rubella and cytomegalovirus antibodies in non-diabetic individuals aged 7?19 years

Detection of Coxsackie B Virus RNA sequences in whole blood samples from adult patients at the onset of type I diabetes mellitus

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