Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea

Hwang, Jung Hye; Kim, Jeong Wook; Hwang, Ji Young; Lee, Kyung Min; Shim, Hye Min; Bae, Young Kyung; Paik, Seung Sam; Park, Hosun

doi:10.3349/ymj.2014.55.6.1562

Cited by 21 publications

(22 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Infectious abortion is a miscarriage caused by intrauterine infection of pathogenic bacteria . The pathogen of infective abortion is usually the parasite in the vagina or intestine (conditional pathogen), sometimes a mixed infection .…”

Section: Introductionmentioning

confidence: 99%

Retracted: Luminescent In(III)‐based coordination polymer for selectively sensing Cr₂O₇²⁻, antibacterial and anti‐inflammatory effect on the infectious abortion

Huang

et al. 2019

Int J of Chemical Kinetics

View full text Add to dashboard Cite

A novel water-stable metal-organic framework based on In(III), namely, [In 3 (btta) 2 -(OH) 3 (H 2 O)]⋅(DMA) 2 (1, DMA = N,, constructed from a novel ligand (2E,2 ′ E,2 ″ E)-3,3 ′ ,3 ″ -(benzene-1,3,5-triyl)triacrylic acid (H 3 btta), was obtained by a solvothermal reaction and structurally characterized by X-ray diffraction of single crystal along with elemental analysis. Owing to its high porosity and insensitive luminescent emission at room temperature, it was studied as a light-emitting sensor for detecting toxic Cr 2 O 7 2− anion in water, which shows high selectivity and sensitivity. To solve the bacterial problem, the protective effect of the compound against bacterial infection after missed abortion was evaluated. In the in vivo model, after the treatment with the compound, the clonal formation unit (CFU) in the uterine tissue was evaluated, and the animal weight was measured and recorded. In addition to this, the level of IL-18, C-reactive protein, TNF-, as well as IL-1 within the infectious tissues was detected by the ELISA method. Pose scoring software and molecular docking showed that the compound might bind to the NF-B protein, and this might offer a latent regulatory mechanism for the compound. K E Y W O R D S bacterial infection, Cr 2 O 7 2sensing, In(III)-complex, inflammatory response, missed abortion, molecular docking, porous framework, thermal shift 178

show abstract

Section: Introductionmentioning

confidence: 99%

Retracted: Luminescent In(III)‐based coordination polymer for selectively sensing Cr₂O₇²⁻, antibacterial and anti‐inflammatory effect on the infectious abortion

Huang

et al. 2019

Int J of Chemical Kinetics

View full text Add to dashboard Cite

show abstract

“…Infections with Coxsackievirus B3 (CVB3) during late pregnancy and delivery have been reported to have significant effects on the fetus, including neurological defects, encephalitis, myocarditis, meningitis, and even death [55][56][57]. According to Hwang et al, when cases of early pregnancy loss were analyzed for the prevalence of enterovirus infection using RT-PCR and immunohistochemistry, the rate of CVB3 infection in cases of abortion was 57.1% [58]. Despite the high rate of fetal death associated with CVB infections, there are limited data regarding the outcome of infection during early pregnancy, since early maternal infections are commonly asymptomatic and therefore undetected.…”

Section: Viral Infections During Pregnancymentioning

confidence: 99%

Recent Updates on Research Models and Tools to Study Virus–Host Interactions at the Placenta

Lee

Park

et al. 2019

Viruses

Self Cite

View full text Add to dashboard Cite

The placenta is a unique mixed organ, composed of both maternal and fetal tissues, that is formed only during pregnancy and serves as the key physiological and immunological barrier preventing maternal–fetal transmission of pathogens. Several viruses can circumvent this physical barrier and enter the fetal compartment, resulting in miscarriage, preterm birth, and birth defects, including microcephaly. The mechanisms underlying viral strategies to evade the protective role of placenta are poorly understood. Here, we reviewed the role of trophoblasts and Hofbauer cells in the placenta and have highlighted characteristics of vertical and perinatal infections caused by a wide range of viruses. Moreover, we explored current progress and future opportunities in cellular targets, pathogenesis, and underlying biological mechanisms of congenital viral infections, as well as novel research models and tools to study the placenta.

show abstract

“…Transmission of EVs from a mother to the fetus and newborn may be antenatal, perinatal, at the time of delivery, or postnatal [2,3]. Existence of several case reports suggest that EV infections during pregnancy may cause meningitis, preterm delivery, neonatal myocarditis, fetal growth retardation, or even embryopathy [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21]. However, intrauterine transmission of EVs is nevertheless discussed with ambiguity.…”

Section: Introductionmentioning

confidence: 99%

Pancreas of coxsackievirus-infected dams and their challenged pups: A complex issue

et al. 2019

View full text Add to dashboard Cite

Enteroviral infections are frequent, often asymptomatic in humans and during gravidity. The present study is an extension of our previous investigations where we had shown pancreatitis in challenged pups of CVB4-E2-infected dams. Present investigation describes the effect of gestational infection with this virus on the pancreas of both dams and their challenged pups. Gravid CD1 outbred mice were orally infected with CVB4-E2 virus at different gestation times. Pups were challenged orally with the same virus after 25 days of birth. Organs were collected at selected intervals postinfection (p.i.), and replicating virus and viral-RNA copies were analyzed. Additional readouts included histopathology and immunohistochemical (IHC) analysis for localization and identification of Ly6G+ cells (neutrophils), CD11b+ cells (macrophages), and viral protein in pancreatic tissue sections of the infected dams and their challenged pups. Our results show the presence of replicating virus in the pancreas of infected dams and their challenged pups, with inflammation leading to chronic necrotizing pancreatitis and atrophy of pancreatic acini of the dams and their offspring. IHC analysis of the infiltrating cells showed pronounced Ly6G+ neutrophils in dams only, whereas CD11b+ macrophages were present in tissues of both, the pups and the dams. Time of infection during gravidity as well as the p.i. intervals when mice were sacrificed influenced the pancreatic pathophysiology in both groups. We conclude that coxsackievirus infection during pregnancy is a risk factor for chronic affliction of the exocrine tissue and could affect endocrine pancreas in the mother and child.

show abstract

Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea

Cited by 21 publications

References 23 publications

Retracted: Luminescent In(III)‐based coordination polymer for selectively sensing Cr₂O₇²⁻, antibacterial and anti‐inflammatory effect on the infectious abortion

Retracted: Luminescent In(III)‐based coordination polymer for selectively sensing Cr₂O₇²⁻, antibacterial and anti‐inflammatory effect on the infectious abortion

Recent Updates on Research Models and Tools to Study Virus–Host Interactions at the Placenta

Pancreas of coxsackievirus-infected dams and their challenged pups: A complex issue

Contact Info

Product

Resources

About

Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea

Cited by 21 publications

References 23 publications

Retracted: Luminescent In(III)‐based coordination polymer for selectively sensing Cr2O72−, antibacterial and anti‐inflammatory effect on the infectious abortion

Retracted: Luminescent In(III)‐based coordination polymer for selectively sensing Cr2O72−, antibacterial and anti‐inflammatory effect on the infectious abortion

Recent Updates on Research Models and Tools to Study Virus–Host Interactions at the Placenta

Pancreas of coxsackievirus-infected dams and their challenged pups: A complex issue

Contact Info

Product

Resources

About

Retracted: Luminescent In(III)‐based coordination polymer for selectively sensing Cr₂O₇²⁻, antibacterial and anti‐inflammatory effect on the infectious abortion

Retracted: Luminescent In(III)‐based coordination polymer for selectively sensing Cr₂O₇²⁻, antibacterial and anti‐inflammatory effect on the infectious abortion