The increased uptake of information and communication technologies (ICTs) is fostering the development of responsive buildings that are aware of and respond to human needs. Current approaches mainly focus on adapting building systems to enhance people’s comfort and energy performance. Little is known about how responsive buildings can inform human behavior adaptability to meet the diverse needs of individuals and organizations within built environments. This study recorded the outcomes of six multi-agent simulation projects exploring human behavior adaptability in different workplace settings. The results have been analyzed through the lenses of ‘place’ theory to extrapolate a framework for human behavior adaptability, jointly considering the characteristics of the spaces, the people that inhabit them, and their activities. This framework provides analytical insights on the design and development of adaptability strategies that consider non-linear interactions and dependencies between the characteristics of the built environment, the needs of the inhabitants, and the goals of organizations.